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H. Peter Lu

Institution
Bowling Green State University

Projects

Microbial Cell Analysis and Imaging

Lead Institution
Bowling Green State University
Principal Investigator
H. Peter Lu
Project type
Exploratory Research
Using state-of-the-art spacial and temporal optical imaging microscopy to study shewanella cells.

Ion Channel Protein Dynamics in Lipid Bilayer

Lead Institution
Bowling Green State University
Principal Investigator
H. Peter Lu
Project type
Exploratory Research
Voltage controlled protein ion channel in lipid bilayer will be studied by using patch-clamp confocal fluorescence imaging microscopy and single molecule spectroscopy.

(emslcsd2462)Graphic Presentation and MD Simulations of Protein Interactions

Lead Institution
Bowling Green State University
Principal Investigator
H. Peter Lu
Project type
Capability Research
This project will utilize molecular dynamics simulations to study the interactions between Cdc42 and one of its downstream effector-WASP in cellular signaling. MD calculations will be performed on…

Single-Molecule Enzymatic Reaction Dynamics

Lead Institution
Bowling Green State University
Principal Investigator
H. Peter Lu
Project type
Exploratory Research
T4 lysozyme catalyzes the hydrolization of the bacterial cell wall and involves complex conformational changes. Although this hydrolization is one of the most important enzymatic reactions, its…

Analysis of Lipid Nanoparticle Interaction with Cell Membrane

Lead Institution
Bowling Green State University
Principal Investigator
H. Peter Lu
Project type
Exploratory Research
Lipid nanoparticle is an important medical agent to cure cancer, especially in gene therapy cancer treatment. To understand the interaction of lipid nanoparticle with cell membrane is critically…

Measure the anisotropy of a membrane protein at a cell membrane.

Lead Institution
University of Washington
Principal Investigator
Jie Zheng
Project type
Exploratory Research
Cyclic nucleotide-gated channels play a key role in sensory transduction of both visual and olfactory systems. CNG channels have been labeled with dye molecules, and a control experiment is needed…

Single Molecule Dymanics of Protein DNA Interactions

Lead Institution
Washington State University
Principal Investigator
Alexander Li
Project type
Exploratory Research
Deoxyribonucleic acid (DNA) and protein interactions are ubiquitous biological systems and their interactions play critical roles in controlling functional cellular systems and abnormal cell…

Computational Study of Membrane Protein Dynamics in Lipid Bilayers

Lead Institution
Bowling Green State University
Principal Investigator
H. Peter Lu
Project type
Exploratory Research
Membrane proteins are extremely important and complex in living cells. Studying the dynamical processes of membrane proteins is crucial for uncovering the fundamental mechanisms and dynamics…

Computational Study of Membrane Protein Dynamics in Lipid Bilayers

Lead Institution
Bowling Green State University
Principal Investigator
H. Peter Lu
Project type
Limited Scope
Membrane proteins are extremely important and complex in living cells. Studying the dynamical processes of membrane proteins is crucial for uncovering the fundamental mechanisms and dynamics…

Computer Simulation of Optical Spectroscopy

Lead Institution
Bowling Green State University
Principal Investigator
H. Peter Lu
Project type
Exploratory Research
Using theoretical model and numerical simulation software to calculate the Raman spectral frequency and chemical bonding identification, as well as related molecular structures.

Computational Study of Colicin Dynamics in Lipid Bilayers

Lead Institution
Bowling Green State University
Principal Investigator
H. Peter Lu
Project type
Exploratory Research
We plan to study the colicin ion channel open-close dynamics involving in protein domains diffuse across the biological membrane under an external electric field. Our work will serve as an adequate…

Computational study of protein-protein interaction dynamics

Lead Institution
State University of New York at Stony Brook
Principal Investigator
Jin Wang
Project type
Capability Research
Protein-protein interactions are extremely important and complex in living cells. Studying the dynamical processes of protein-protein interactions is crucial for uncovering the fundamental…

Computational study of protein-protein interaction dynamics

Lead Institution
State University of New York at Stony Brook
Principal Investigator
Jin Wang
Project type
Exploratory Research
Protein-protein interactions are extremely important and complex in living cells. Studying the dynamical processes of protein-protein interactions is crucial for uncovering the fundamental…

(emslcsd4)Graphic presentation of conformational motions of dye-labeled enzyme

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Dehong Hu
Project type
Capability Research
We have studied the conformation change of enzyme molecules by single molecule spectroscopy by monitoring the energy transfer efficiency of dyes labeled on the enzyme. In additional to spectroscopy…

Site-specific spectroscopy and optical imaging.

Lead Institution
Bowling Green State University
Principal Investigator
H. Peter Lu
Project type
Exploratory Research
To obtain chemical and biological characterization at nanoscale using fluorescence and Raman spectroscopy and imaging.

AFM-enhanced FLIM and Raman imaging.

Lead Institution
Bowling Green State University
Principal Investigator
H. Peter Lu
Project type
Exploratory Research
Metallic AFM tip enhanced spectroscopy will be developed and applied to study chemical process and biological process.

Single-molecule imaging at LB bilayers

Lead Institution
Bowling Green State University
Principal Investigator
H. Peter Lu
Project type
Exploratory Research
The proposed experiments with the LB trough are to create lipid bi-layer membranes with low concentrations of either fluorescence labeled lipids and/or low concentrations of fluorescence labeled…

Protein-protein interaction dynamics.

Lead Institution
Bowling Green State University
Principal Investigator
H. Peter Lu
Project type
Exploratory Research
Protein-protein interaction dynamics is highly complex and inhomogeneous. Single molecule spectroscopy will be applied to study these complex interactions one molecule at a time.