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Single Molecule Approach for Understanding EGFR Molecular Interactions (Orr LDRD-FRET, PNNL Scope #48287)


EMSL Project ID
6494

Abstract

We will use cutting edge fluorescence imaging techniques to study the molecular interactions of EGFR with other molecules in the pathway to better understand its role in determining cell fate.

Project Details

Project type
Exploratory Research
Start Date
2003-12-12
End Date
2006-12-17
Status
Closed

Team

Principal Investigator

Galya Orr
Institution
Environmental Molecular Sciences Laboratory

Team Members

David Panther
Institution
Pacific Northwest National Laboratory

H Wiley
Institution
Environmental Molecular Sciences Laboratory

Haluk Resat
Institution
Pacific Northwest National Laboratory

Lee Opresko
Institution
Pacific Northwest National Laboratory

Dehong Hu
Institution
Environmental Molecular Sciences Laboratory

Related Publications

Harms G., Orr G., Lu H.P (2004) Probing Single-Molecule Ion Channel Conformational Dynamics Using Combined Ultrafast Spectroscopy and Patch-Clamp Recording. Applied Physics Letters. 84:1792-1794.