Implementation of Systems Toxicology for an Animal Emphysema Model
EMSL Project ID
9297
Abstract
The objective of this study is to establish a procedure on how to best incorporate the comprehensive systems toxicology database in a prototype lung disease model, the elastase-induced emphysema mouse model. The project will integrate and compare the whole range of toxicity assessments, such as clinical and anatomical histopathology, genomics, proteomics, and metabonomics endpoints of this lung disease model. The results will allow Battelle staff to be familiar with and to gain hands-on experiences in gathering data and identifying specific profiles for each of the systems toxicology components (genomics; proteomics; metabonomics) during the emphysema development. Integrating these profiles and correlating against phenotypes (clinical chemistry, histology and lung morphometry) should clarify the mechanism of pathogenesis and relationship and interaction among each component and to phenotypes
Project Details
Project type
Exploratory Research
Start Date
2004-06-14
End Date
2004-10-18
Status
Closed
Released Data Link
Team
Principal Investigator