Implementation of Systems Toxicology for an Animal Emphysema Model
EMSL Project ID
9297
Abstract
The objective of this study is to establish a procedure on how to best incorporate the comprehensive systems toxicology database in a prototype lung disease model, the elastase-induced emphysema mouse model. The project will integrate and compare the whole range of toxicity assessments, such as clinical and anatomical histopathology, genomics, proteomics, and metabonomics endpoints of this lung disease model. The results will allow Battelle staff to be familiar with and to gain hands-on experiences in gathering data and identifying specific profiles for each of the systems toxicology components (genomics; proteomics; metabonomics) during the emphysema development. Integrating these profiles and correlating against phenotypes (clinical chemistry, histology and lung morphometry) should clarify the mechanism of pathogenesis and relationship and interaction among each component and to phenotypes
Project Details
Project type
Exploratory Research
Start Date
2004-06-14
End Date
2004-10-18
Status
Closed
Released Data Link
Team
Principal Investigator
Related Publications
Berg L.K., J.D. Fast, W.I. Gustafson, H. Xiao, Z. Feng, H.C. Barnes, and J. Kleiss, et al. 04/09/2018. "Large Eddy Simulation of Shallow to Deep Convective Cloud Transitions during HI-SCALE." Presented by Larry K Berg at EGU, Vienna, Austria. PNNL-SA-133441.
Chen J., S.M. Hagos, H. Xiao, J.D. Fast, and Z. Feng. 01/15/2020. "Characteristics of Surface Heterogeneity Induced Convection." Presented by J. Chen at Wayne Schubert Symposium in conjunction with the 100th Annual American Meteorological Society Meeting, Boston, Massachusetts. PNNL-SA-150366.
Chen J., S.M. Hagos, H. Xiao, R.A. Houze, J.D. Fast, and Z. Feng. 06/10/2019. "Investigating the Mechanisms of Shallow Precipitating Clouds Formation during the HI-SCALE Field Campaign." Bethesda, Maryland. PNNL-SA-144262.
Fast J D,Berg L K,Alexander L ,D'Ambro E ,Bell D M,Brown E ,Eiguren A ,Hubbe J M,Kuang C ,Lindenmaier R ,Liu J ,Matthews A A,Mei F ,Pekour M S,Pinterich T ,Schmid B ,Schobesberger S ,Shilling J E,Smith J N,Springston S ,Stark H ,Suski K J,Thornton J A,Wang J ,Zelenyuk-Imre A 2016. "The Holistic Interactions of Shallow Clouds, Aerosols, and Land-Ecosystems (HI-SCALE) Campaign: Measurement Strategy and Preliminary Findings"
Fast J D,Berg L K,Schmid B ,Alexander L ,Bell D M,D'Ambro E ,Hubbe J M,Liu J ,Mei F ,Pekour M S,Pinterich T ,Schobesberger S ,Shilling J E,Springston S R,Thornton J A,Tomlinson J M,Wang J ,Zelenyuk-Imre A 2016. "The Holistic Interactions of Shallow Clouds, Aerosols, and Land-Ecosystems Campaign: Measurement Strategy and Preliminary Findings "
Fast J.D., H. Xiao, J. Chen, M.B. Shrivastava, and R.A. Scanza. 08/09/2018. "WRF-LES-Chem Over the Southern Great Plains." Presented by J.D. Fast at Future Role of Large-Eddy Simulations (LES) models for Air Quality Workshop, Boulder, Colorado. PNNL-SA-137107.
Fast J.D., L.A. Berg, R.K. Newsom, H. Xiao, S. Tai, and J.D. Tagestad. 06/12/2018. "Observed and Simulated Heterogeneity in Boundary Layer Turbulence and Shallow Convective Clouds during the HI-SCALE Campaign." Presented by Jerome D Fast at 23 Symposium on Boundar Layers and Turbulence, Oklahoma City, Oklahoma. PNNL-SA-135769.
Fast JD, LK Berg, B Schmid, L Alexander, DM Bell, E D'Ambro, JM Hubbe, J Liu, F Mei, MS Pekour, T Pinterich, S Schobesberger, JE Shilling, SR Springston, JA Thornton, JM Tomlinson, J Wang, and A Zelenyuk-Imre. 2016. "Improving the Understanding and Model Representation of Processes that Couple Shallow Clouds, Aerosols, and Land-Ecosystems ." Abstract submitted to American Geophysical Union Fall Meeting, SAN FRANCISCO, CA. PNNL-SA-119981.
Fast JD, LK Berg, B Schmid, LJ Alexander, E D'Ambro, DM Bell, A Eiguren, JM Hubbe, C Kuang, R Lindenmaier, J Liu, AA Matthews, F Mei, MS Pekour, T Pinterich, S Schobesberger, JE Shilling, JN Smith, S Springston, H Stark, KJ Suski, JA Thornton, J Wang, and A Zelenyuk-Imre. 2017. "The Holistic Interactions of Shallow Clouds, Aerosols, and Land-Ecosystems (HI-SCALE) Campaign: Measurement Strategy and Preliminary Findings." Presented by Jerome D Fast at ARM/ASR PI Meeting, FAIRFAX, VA on March 14, 2017. PNNL-SA-124558.
Fast J.D., L.K. Berg, D.M. Bell, B.H. Lee, J. Liu, F. Mei, and J.E. Shilling, et al. 01/10/2018. "Aerosol-Cloud Interactions Observed during the Holistic Interactions of Shallow Clouds, Aerosols, and Land Ecosystems (HI-SCALE) Campaign." Abstract submitted to American Meteorological Society, Austin, Texas. PNNL-SA-131625.
Fast J.D., L.K. Berg, H.C. Barnes, Z. Feng, W.I. Gustafson, and H. Xiao. 12/13/2018. "Comparison of LES Methodologies in the Representation of Shallow Convective Cloud Populations Observed during the HI-SCALE Campaign." Presented by J.D. Fast at AGU Fall Meeting, Washington, District Of Columbia. PNNL-SA-140040.
Fast J.D., L.K. Berg, J. Chen, R.K. Newsom, M.S. Pekour, J.D. Tagestad, and S. Tai, et al. 12/11/2018. "Observed and Simulated Coupling of Land-Atmosphere Interactions, Boundary Layer Turbulence, and Shallow Convective Clouds during HI-SCALE." Abstract submitted to American Geophysical Union, Washington, District Of Columbia. PNNL-SA-136824.
Fast J.D., L.K. Berg, W.I. Gustafson, H. Xiao, S. Endo, Z. Feng, and H.C. Barnes, et al. 03/20/2018. "Large Eddy Simulations of Shallow to Deep Convective Cloud Transitions during HI-SCALE." Presented by Jerome D Fast at 2018 ARM/ASR Principal Investigator Meeting, Vienna, Virginia. PNNL-SA-135573.
Fast, J., L. Berg, L. Alexander, D. Bell, E. D’Ambro, J. Hubbe, C. Kuang, J. Liu, C. Long, A. Matthews, F. Mei, R. Newsom, M. Pekour, T. Pinterich, B. Schmid, S. Schobesberger, J. Shilling, J. Smith, S. Springston, K. Suski, J. Thornton, J. Tomlinson, J. Wang, H. Xiao, and A. Zelenyuk, 2018: Overview of the HI-SCALE Field Campaign: A New Perspective on Shallow Convective Clouds. Bull. Amer. Meteor. Soc. doi:10.1175/BAMS-D-18-0030.1, in press.
Shrivastava, M., A. Zelenyuk-Imre, D. Bell, J. Fast, J. Thornton, D. Imre, K. Suski, L. Berg, J. Shilling, J. Liu, F. Mei, J. Tomlinson, and J. Wang, 2018: Insights into isoprene-epoxydiol (IEPOX-SOA) chemistry in cloud droplets using WRF-Chem and HI-SCALE field observations. Poster. ARM/ASR Principal Investigator Meeting, Vienna, VA, March 19 - 23. PNNL-SA-131946.
Shrivastava M.B., A. Zelenyuk-Imre, D.M. Bell, J.D. Fast, J.A. Thornton, D.g. Imre, and K.J. Suski, et al. 09/04/2018. "Insights into Isoprene-Epoxydiol (IEPOX-SOA) chemistry in Cloud Droplets using WRF-Chem and HI-SCALE field observations." Abstract submitted to International Aerosol Conference 2018, St. Louis, Moscow. PNNL-SA-132081.
Wang H. C.D. Burleyson P. Ma J.D. Fast and P.J. Rasch. 2018. Using the Atmospheric Radiation Measurement (ARM) Datasets to Evaluate Climate Models in Simulating Diurnal and Seasonal Variations of Tropical Clouds." Journal of Climate 31 no. 8:3301–3325. PNNL-SA-125329. doi:10.1175/JCLI-D-17-0362.1
Zelenyuk-Imre, A., D. Bell, M. Shrivastava, J. Fast, J. Thornton, K. Suski, D. Imre, L. Berg, J. Shilling, J. Liu, F. Mei, J. Tomlinson, J. Wang, and M. Pekour, 2018: Direct observations of the formation of isoprene-derived secondary organic aerosol in ambient cloud droplets. Poster. ARM/ASR Principal Investigator Meeting, Vienna, VA, March 19 - 23.
Zelenyuk-Imre A., D.M. Bell, M.B. Shrivastava, J.D. Fast, J.A. Thornton, D. Imre, and K.J. Suski, et al. 09/04/2018. "Direct Observations of the Formation of Isoprene-derived Secondary Organic Aerosol in Ambient Cloud Droplets." Abstract submitted to 2018 International Aerosol Conference, St Louis, Mississippi. PNNL-SA-135148.