Projects

As a scientific user facility, the Environmental Molecular Sciences Laboratory (EMSL) provides expertise, instrumentation, and resources to 250 projects each year.

EMSL projects displayed on the EMSL web site project page reflect project abstracts and information migrated to this page before April 30, 2024. To review current and past EMSL user projects, visit EMSL Science Central.™

Electronic and Optical Properties of Doped Complex Oxide Epitaxial Films and Interfaces

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Scott Chambers

Project type

Large-Scale EMSL Research

The effect of A-cation site and anion-site doping, as well as heteroepitaxial interface formation, on the electronic and optical properties of La-based perovskites will be investigated. Specimens…

Experimental Capabilities and Fundamental Science for Geologic Carbon Sequestration: The PNNL In Situ Supercritical Suite (IS3)

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

John Loring

Project type

Large-Scale EMSL Research

This Science Theme proposal requests EMSL access for investigators in the In Situ Supercritical Suite (IS3) component of PNNL's Carbon Sequestration Initiative (CSI). The CSI is a multi-million…

EMSL/FCSD Scientific Partner Proposal on the Dynamics of Biological and Catalytic Systems

Lead Institution

University of Liverpool

Principal Investigator

Nigel Browning

Project type

Scientific Partner

The goal of this Scientific Partner Proposal is to develop the capability to observe “live” biological and catalytic processes in the dynamic transmission electron microscope (DTEM). Live biological…

Coupled Surface and Solid-State Charge and Ion Transport Dynamics at Mineral/Water Interfaces: Redox Transformation of the Iron Oxides

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Kevin Rosso

Project type

Large-Scale EMSL Research

This EMSL user proposal requests a continuation of EMSL access for a BES Geosciences supported project led by Dr. Rosso at PNNL. The past three years of research under this BES project we have been…

A Systems Biology Approach to Infectious Diseases Research for EnteroPathogens

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Joshua Adkins

Develop and apply new "Systems Biology" approaches to the study of bacterial pathogen species Salmonella and Yersinia, this includes proteomics, transcriptomics, metabolomics, lipidomics,…

Determining the Conformational Changes within an Active Enzyme-Substrate System on both Sides of the Reaction.

Lead Institution

University of Colorado at Denver

Principal Investigator

Elan Eisenmesser

Project type

Large-Scale EMSL Research

Our objective is to develop solution-based strategies that directly monitor the physical conformational changes that occur within enzymes, both free and during enzyme catalysis. These strategies are…

Genome-enabled studies of key light-dependent metabolic and regulatory switches governing reductant and carbon partitioning in cyanobacteria

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Alex Beliaev

Project type

Large-Scale EMSL Research

The main goal of this proposal is develop and apply an integrated omics approach for systems-level analysis of photosynthetic metabolism in cyanobacteria that will lead to the identification of key…

Computational Chemical Dynamics of Complex Systems

Lead Institution

University of Minnesota

Principal Investigator

Donald Truhlar

Project type

Large-Scale EMSL Research

The ultimate goal of this project is to develop and apply innovative user-friendly high-performance computing techniques and simulation methods for computational chemical dynamics of complex systems…

Computational Study of Colicin Dynamics in Lipid Bilayers

Lead Institution

Bowling Green State University

Principal Investigator

H. Peter Lu

Project type

Exploratory Research

We plan to study the colicin ion channel open-close dynamics involving in protein domains diffuse across the biological membrane under an external electric field. Our work will serve as an adequate…

Understanding structure-function relationships for developing catalysts for energy storage and production reactions.

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Wendy Shaw

Project type

Large-Scale EMSL Research

The DOE Basic Energy Sciences Energy Frontier Research Center entitled “Center for Molecular Electrocatalysis” (Bullock), the DOE Basic Energy Sciences “Modular Energy-Based Approach to Molecular…

Intermediate-scale Laboratory Experiments to Evaluate Pore-water Extraction from Hanford Sediments

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Mart Oostrom

Preliminary flow cell experiments have demonstrated that sustained pore-water extraction from unsaturated sediments can be obtained under highly controlled conditions in the laboratory. The design…

Chromatographic Partitioning of Impure CO2 during Injection and Redistribution at the Pore Scale

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Mart Oostrom

In this project, we propose to conduct a series of pore network laboratory experiments to study the fate and transport of gaseous mixtures in model saline aquifer systems during injection of the…

Examination with atom probe tomography (APT) of environmentally degraded grain boundaries from a turbine disk Ni-based superalloy ME3

Lead Institution

NASA Glenn Research Center

Principal Investigator

Chantal Sudbrack

Project type

Limited Scope

The focus of this work is to investigate the chemistry of interior grain boundaries from the fatigued volume of tested notched low cycle fatigue (NLCF) specimens of an advanced powder metallurgy…

Physiologically-Based Biokinetic Model for Bacillus anthracis

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Richard Jacob

Project type

Limited Scope

The objective of this work is to develop a preliminary predictive model for inhalational anthrax through the use of published literature as well as in vivo and in vitro data that have been, and will…

Activity-Based Protein Profiling of Enzyme Ontogeny: Metabolism in Sensitive Life Stages

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Richard Corley

Metabolism is a key step in the activation of many procarcinogens, including the polyaromatic hydrocarbon (PAH) dibenzo[def,p]chrysene (DBC). DBC is a highly potent carcinogenic PAH, capable of…

In Situ Measurement of Organic Contaminants in CO2-Water Solutions Using Near-Infrared Spectroscopy

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Christopher Thompson

Geologic carbon sequestration (GCS) is considered to be one of the more viable options for reducing anthropogenic emissions of greenhouse gases. At sites where depleted oil reservoirs or coal beds…

Development of Electrical Resistivity Tomography Techniques for the Determination of Porous Media Water Saturations and Formation Factors in Laboratory Columns

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Mart Oostrom

Recently, DOE-RL has funded a project proposal to develop a laboratory Electrical Resistivity Tomography (ERT) technique to determine water saturations in the subsurface based on conductivity changes…

AlN- and SiN-based Phosphors

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Carlos Fernandez

Project type

Limited Scope

Nitrides and oxynitrides have attracted significant attention in recent years because of their remarkable (thermal and chemical) stability, good fracture toughness while exhibiting unusual…

Massively Parallel Molecular Profiling of Breast Cancer

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Richard Smith

Molecular profiling of breast cancer into subcategories based on functional ER expression and amplification of HER2 has significantly enhanced our understanding of the disease, and has pointed the…

Elemental mobility in carbon dioxide reservoir caprocks.

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Eirik Krogstad

Project type

Limited Scope

Cap rocks for CO2 reservoirs are important to understand, as they must remain patent, or nearly so, to passage or leakage of CO2 and, if they leak, not represent a dangerous source of toxic metals…

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