Projects

Molecular dysfunction in alcoholic liver disease.

Lead Institution

Wayne State University

Principal Investigator

Amit Banerjee

Project type

Exploratory Research

Mice transgenic for the human Cytochrome P450 2E1 (primary metabolizer of alcohols in the liver) were fed alcohol intra-gastrically for a month. Upon examination of the liver microscopically,…

Engineering Device Surfaces That Instruct Cell Behavior

Lead Institution

University of Washington

Principal Investigator

Allison Golden

Project type

Exploratory Research

The development of material interfaces that control cell behavior is a central challenge for the fields of diagnostics, drug screening, biomaterials, biosensors, and tissue engineering. The…

Characterization of Natural Gas Methane Hydrate Rich Sediment

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Herbert Schaef

Project type

Exploratory Research

Synthetic and natural gas hydrate samples (NGHP-01, Mt Elbert) will be characterized by FIB-SEM equipped with a cryo stage and residual gas analyzer. Gas hydrate dissociation profiles collected on…

Signal Transmissions in 3-Dimensional Cell Structures

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Lee Opresko

Project type

Exploratory Research

MCF 10A cells will be examined for signal transduction in response to external stimulus.

Characterization of Regenerable CO2 Sorbents

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Feng Zheng

Project type

Exploratory Research

Several modified mesoporous silica and activated carbon sorbents were developed at PNNL for CO2 removal. Initial tests show that these sorbents have high adsorption capacity for CO2. The work…

Abundance of protein components in photosystem II protein complex purified from mutant cyanobacterial cells lacking individual subunit protein

Lead Institution

Washington University in St. Louis

Principal Investigator

Himadri Pakrasi

Project type

Exploratory Research

Photosystem II (PSII) is the pigment-protein complex responsible for the process of converting water to molecular oxygen and subsequent carbon fixation during oxygenic photosynthesis. PSII consists…

Using Mass Spectrometry to Assist in Identifying Genes for Enzymes of Known Activity, Unknown OpenReadingFrame and Small Abundance

Lead Institution

Washington University in St. Louis

Principal Investigator

Daniel Kohl

Project type

Exploratory Research

We have reported the identification of the Open Reading Frame (ORF) that expresses a NADPH-dependent methylglyoxal reducing enzyme based on the partial purification of this activity through 3 simple…

Chemical Processing of Terpene Emissions from Forests

Lead Institution

Argonne National Laboratory

Principal Investigator

Paul Doskey

Project type

Exploratory Research

Evaluations of NMOC emission inventories developed for rural and urban areas (which contain large uncertainties) necessitate direct measurement of landscape-scale fluxes. The main objectives of this…

The characterization of the SiC/SiO2/C composite

Lead Institution

Washington State University Tri-Cities

Principal Investigator

Hai-Feng Zhang

Project type

Exploratory Research

We have developed an approach to synthesize the nano-crysatlline composite materials of SiC/SiO2/C, TGA and FTIR are very efficient tools for determining the ratio of the componens in the composite…

Computational Investigation of the Fixed Charge Derivative Tris[(2,4,6-trimethoxyphenyl) phosphonium]

Lead Institution

University of Arizona

Principal Investigator

Kristin Herrmann

Project type

Exploratory Research

Proteomic studies often rely upon liquid chromatography (LC)/tandem mass spectrometry (MS) measurements in conjunction with sequencing algorithms for the identification of proteins. When a peptide…

Fuel-Neutral Studies of Particulate Matter Transportation Emissions

Lead Institution

University of Wisconsin, Madison

Principal Investigator

David Foster

Project type

Exploratory Research

Customers and governments are demanding greater fuel efficiency in light duty engine applications. Since the majority of light duty engines in North America are fueled by gasoline, gasoline engine…

The Role of Interfacial Processes on Mineral Transformations in Wet Supercritical CO2

Lead Institution

Washington State University

Principal Investigator

Andrew Felmy

Project type

Exploratory Research

We propose a comprehensive experimental and theoretical investigation of the role of interfacial water and CO2 on the energies, mechanisms, and rates of reactivity of a series of orthosilicate and…

Enhanced Amendment Delivery to Low Permeability Zones in Unconfined Aquifers Using Shear-Thinning Fluid

Lead Institution

GSI Environmental Inc.

Principal Investigator

Charles Newell

Project type

Exploratory Research

Zhong et al. (2008) conducted a series of flow cell experiments in the EMSL Subsurface Flow and Transport Laboratory using the shear-thinning polymer xanthan gum to investigate the impact of polymer…

The Impact of Vapor Phase Species on the Corrosion Potential of Hanford Double Shell Tanks.

Lead Institution

Washington State University

Principal Investigator

Andrew Felmy

Project type

Exploratory Research

The goal of the proposed project is to develop a sound technical basis for control of corrosion in the vapor space and the liquid/air interface (VS/LAI) in the Hanford Double Shell Tanks. …

Luminescence Spectroscopic Study of europium(III) with alpha-hydroxy isobutyric acid in 1,4-dioxane

Lead Institution

Washington State University

Principal Investigator

Ken Nash

Project type

Exploratory Research

It has been previously demonstrated that the ligand, alpha-hydroxy isobutyric acid (HIBA) shows remarkably efficient separations of trivalent lanthanides when compared to other carboxylic acids. …

Identify Morphology of Initial LIGO Core Optics Scatter Sites: Year 2

Lead Institution

California Institute of Technology

Principal Investigator

Cheryl Vorvick

Project type

Exploratory Research

The core optics in the Initial LIGO project all show numerous scatter points when illuminated by the interferometer beam. The scatter points are a source of loss in the interferometer, and thus are a…

EFFECT OF STRUCTURE AND SURFACE CHEMISTRY ON ELECTRODE REACTIONS IN SOLID OXIDE FUEL CELLS

Lead Institution

Boston University

Principal Investigator

Srikanth Gopalan

Project type

Exploratory Research

One of the most intriguing questions about solid oxide fuel cells is the relative importance of gas-solid interfaces including three-phase boundaries between electrode, electrolyte and gas with…

Atomistic Modeling of Corrosion Accelerants in the Petroleum Industry

Lead Institution

Los Alamos National Laboratory

Principal Investigator

Christopher Taylor

Project type

Exploratory Research

Materials selection is critical to petroleum refining operations, due to the frequently aggressive chemical, flow and thermal conditions encountered by structural components such as pipelines and…

A Systems Biology Approach to Infectious Diseases Research

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Joshua Adkins

Project type

Exploratory Research

We describe an integrated program for coupling advanced capabilities in high-throughput transcriptomics, proteomics, and metabolomics with a comprehensive informatics infrastructure and a…

Hydrogen Bonds in Solid Hydrates of Aqueous Salts studied by
Quantum Simulations and Sub-picosecond Infrared Spectroscopy

Lead Institution

Technische Universität München

Principal Investigator

Alfred Laubereau

Project type

Exploratory Research

Solid hydrates of salts containing a fixed ratio of water molecules in their crystal structures have attracted special interest due to their importance in geology, chemistry, and physics. The quest…