Projects

Global Analysis of Histone Post-translational Modifications Specific to Rett Syndrome using 2D RPLC/WCX-HILIC for Online Top-down Mass Spectrometry

Lead Institution

University of Edinburgh

Principal Investigator

Patrick Langridge-Smith

Project type

Exploratory Research

Epigenetics is a rapidly expanding field in biology, due to many technological breakthroughs and a greater understanding of the mechanisms of gene regulation. The location of epigenetic markers such…

Carbon Nanotube-Intestinal Barrier Cell Interactions, Absorption, and Dosimetry

Lead Institution

Indiana University School of Medicine

Principal Investigator

Frank Witzmann

Project type

Exploratory Research

Carbon nanotubes (CNT) are important components of the rapidly expanding nanotechnology field. Due to their size and unique chemical, electrical, mechanical, and thermal properties, they have found…

Electron-Acceptor Fullerene Materials for Organic Photovoltaics: Electronic Properties in Gas-Phase, Solution, Solid-Phase and in Donor/Acceptor Blends

Lead Institution

Colorado State University

Principal Investigator

Steven Strauss

Project type

Exploratory Research

This project will focus on understanding of the fundamental relationships between molecular structures of perfluoroalkylated fullerenes (PFAFs) and their electronic properties in the gas-phase, in…

An integrated top-down / bottom-up method to identify disease related antibodies

Lead Institution

Erasmus University Medical Center, Rotterdam

Principal Investigator

Theo Luider

Project type

Exploratory Research

We describe the discovery of a new class of biomarkers derived from immunoglobulins using mass spectrometry. We previously investigated this approach in model systems with bottom-up proteomics, and…

Comparative analysis of the Mosquito Vector and Vertebrate Host of Dengue Virus: Characterizing the Membrane Structures Required for Virus Replication

Lead Institution

Purdue University

Principal Investigator

Rushika Perera

Project type

Exploratory Research

This proposal is submitted in response to EMSL's science theme "Biological Interactions and dynamics." Our objective is to use high-resolution mass spectrometry and time-lapse single…

Leveraging rRNA pseudouridylation defects to identify operational programmed -1 ribosomal frameshift signals in yeast, mice and human cells.

Lead Institution

University of Maryland, College Park

Principal Investigator

Jonathan Dinman

Project type

Exploratory Research

Programmed -1 ribosomal frameshifting (-1 PRF) is a molecular mechanism in which cis-acting signals direct a fraction of elongating ribosomes to slip by 1 nucleotide in the 5-prime direction along an…

Mesocrystalline Positive Electrode Materials for Lithium-Ion Battery

Lead Institution

University of Washington

Principal Investigator

Guozhong Cao

Project type

Exploratory Research

The applied use of nanoparticles has been the subject of intense research over the past several decades due to the novel properties and tunable functions of nanoparticles that can be utilized in a…

Hanford GW/VZ Science Integration (Zachara EM-GW/VZ, PNNL Scope # 32326)

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

John Zachara

Project type

Exploratory Research

Incorporate science into the Hanford Ground Water Vadose Zone Integration project. This approach will include coordinating and engaging technical exchanges with principal investigators of current and…

Resonant X-ray spectroscopy of molecules and molecular assemblies using STEX and TDDFT

Lead Institution

University of California, Irvine

Principal Investigator

Shaul Mukamel

Project type

Exploratory Research

This is a three-pronged proposal aimed to address excited state properties in molecules and materials using linear-response TDDFT, real-time electronic dynamics and high-level coupled cluster…

Interaction of Radiolytic Species with Noble Metal Particles in Used Nuclear Fuel

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Frances Skomurski

Project type

Exploratory Research

Noble metal particles (NMP) in used nuclear fuel are nanometer to micron sized alloys of the fission product elements Mo, Tc, Rh, Ru, and Pd. These metals are largely incompatible with the…

Pore-scale Carbon Biogeochemical Processes in Soils and Their Impact to Climate Models

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Chongxuan Liu

Project type

Exploratory Research

Carbon (C) flux from terrestrial soils is an important component in Earth System Models (ESMs) to simulate global carbon cycling and its effect on climate changes. One major challenge to reliably…

Dynamic Bioresponsive Nanomaterials Captured by Dynamic Transmission Electron Microscopy and High Resolution Optical Microscopy

Lead Institution

University of California, San Diego

Principal Investigator

Nathan Gianneschi

Project type

Large-Scale EMSL Research

The overarching goal of this research program is to develop discrete, biomolecule encoded nanomaterials capable of responding to their environment through fundamental changes in their morphological,…

Influence of Mass transfer on Bioavailablility and Kinetic Rate of U(VI) Biotransformation (Liu NABIR-U, PNNL Scope # 45386. Liu NABIR.)

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Chongxuan Liu

Project type

Exploratory Research

Enhance our understanding on the mechanisms that influence uranium bioavailability and kinetic rate of biotransformation in contaminated sediments.

Investigating NOy and Secondary Organic Aerosol Formation Chemistry in the Colorado Front Range: WRF/Chem Model Studies In Support of the Beachon 2011 Field Campaign

Lead Institution

Reed College

Principal Investigator

Juliane Fry

Project type

Exploratory Research

The chemistry of an urban plume interacting downwind with a high-monoterpene emitting forest, including particular focus on atmospheric particle formation, will be explored by a large, collaborative…

Investigating the Effects of Geologic CO2 Sequestration on Microbial Physiology, Metabolism and Functionality.

Lead Institution

Colorado State University

Principal Investigator

Michael Wilkins

Project type

Exploratory Research

The injection of greenhouse gases into deep geologic formations offers a promising strategy for reducing emissions into the atmosphere that contribute to global warming. The injection of CO2 as a…

Toward the chemical conversion of CO2: understanding the interaction of CO2 with model metal/metal-oxide systems

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Janos Szanyi

Project type

Exploratory Research

Environmental concerns about the increasing level of atmospheric CO2, a major greenhouse gas component, have prompted research efforts in two major directions: sequestration and chemical conversion…

High Resolution Infrared Spectroscopy of Radialene

Lead Institution

Oregon State University

Principal Investigator

Joseph Nibler

Project type

Exploratory Research

The structures and physical properties of small organic strained-ring systems are of interest to both experimental and theoretical chemists. The objective of the proposed research is to apply high…

Multiscale Processes of Heteroepitaxial Nucleation and Growth at Mineral-Water Interfaces

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Sebastien Kerisit

Project type

Exploratory Research

The goal of the proposed research is to elucidate the mechanisms and quantify the rates of heteroepitaxial nucleation and growth at mineral-water interfaces. Despite several examples of heteroepitaxy…

Light Source Photocathode Performance and Development

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Wayne Hess

Project type

Exploratory Research

Accelerator photocathode technology must be advanced to meet the needs of fourth generation light sources. The ultimate output characteristics and cost of next-generation ultraviolet or x-ray…

Experimental and Computational Characterization of the Structure and Electronic Properties of Novel Porphyrins for Solar Cells

Lead Institution

Portland State University

Principal Investigator

Carl Wamser

Project type

Exploratory Research

The proposed project will be primarily computational studies carried out in collaboration with Dr. Niri Govind, Dr. Kenneth Lopata, and Dr. Karol Kowalski (PNNL/EMSL Molecular Science Computing). …