Projects

CLM4 simulations for the Multi-scale Synthesis and Terrestrial Model Intercomparison Project (MsTMIP)

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Maoyi Huang

Project type

Exploratory Research

In this project, we will conduct global and regional simulations of the community land model (CLM4) as required by the CLM4 simulations for the Multi-scale Synthesis and Terrestrial Model…

Cardiac Metabolism and Protein Synthesis during Extracorporeal Life Support

Lead Institution

Seattle Children's Research Institute

Principal Investigator

Michael Portman

Project type

Exploratory Research

Mechanical Circulatory Support (MCS) in the form of cardiopulmonary bypass (CPB) is commonly used for infants and children. Extracorporeal life support (ECLS) also a form of MCS remains the primary…

Global Analysis of Histone Post-translational Modifications Specific to Rett Syndrome using 2D RPLC/WCX-HILIC for Online Top-down Mass Spectrometry

Lead Institution

University of Edinburgh

Principal Investigator

Patrick Langridge-Smith

Project type

Exploratory Research

Epigenetics is a rapidly expanding field in biology, due to many technological breakthroughs and a greater understanding of the mechanisms of gene regulation. The location of epigenetic markers such…

Carbon Nanotube-Intestinal Barrier Cell Interactions, Absorption, and Dosimetry

Lead Institution

Indiana University School of Medicine

Principal Investigator

Frank Witzmann

Project type

Exploratory Research

Carbon nanotubes (CNT) are important components of the rapidly expanding nanotechnology field. Due to their size and unique chemical, electrical, mechanical, and thermal properties, they have found…

Electron-Acceptor Fullerene Materials for Organic Photovoltaics: Electronic Properties in Gas-Phase, Solution, Solid-Phase and in Donor/Acceptor Blends

Lead Institution

Colorado State University

Principal Investigator

Steven Strauss

Project type

Exploratory Research

This project will focus on understanding of the fundamental relationships between molecular structures of perfluoroalkylated fullerenes (PFAFs) and their electronic properties in the gas-phase, in…

An integrated top-down / bottom-up method to identify disease related antibodies

Lead Institution

Erasmus University Medical Center, Rotterdam

Principal Investigator

Theo Luider

Project type

Exploratory Research

We describe the discovery of a new class of biomarkers derived from immunoglobulins using mass spectrometry. We previously investigated this approach in model systems with bottom-up proteomics, and…

Comparative analysis of the Mosquito Vector and Vertebrate Host of Dengue Virus: Characterizing the Membrane Structures Required for Virus Replication

Lead Institution

Purdue University

Principal Investigator

Rushika Perera

Project type

Exploratory Research

This proposal is submitted in response to EMSL's science theme "Biological Interactions and dynamics." Our objective is to use high-resolution mass spectrometry and time-lapse single…

Leveraging rRNA pseudouridylation defects to identify operational programmed -1 ribosomal frameshift signals in yeast, mice and human cells.

Lead Institution

University of Maryland, College Park

Principal Investigator

Jonathan Dinman

Project type

Exploratory Research

Programmed -1 ribosomal frameshifting (-1 PRF) is a molecular mechanism in which cis-acting signals direct a fraction of elongating ribosomes to slip by 1 nucleotide in the 5-prime direction along an…

Mesocrystalline Positive Electrode Materials for Lithium-Ion Battery

Lead Institution

University of Washington

Principal Investigator

Guozhong Cao

Project type

Exploratory Research

The applied use of nanoparticles has been the subject of intense research over the past several decades due to the novel properties and tunable functions of nanoparticles that can be utilized in a…

Hanford GW/VZ Science Integration (Zachara EM-GW/VZ, PNNL Scope # 32326)

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

John Zachara

Project type

Exploratory Research

Incorporate science into the Hanford Ground Water Vadose Zone Integration project. This approach will include coordinating and engaging technical exchanges with principal investigators of current and…

Resonant X-ray spectroscopy of molecules and molecular assemblies using STEX and TDDFT

Lead Institution

University of California, Irvine

Principal Investigator

Shaul Mukamel

Project type

Exploratory Research

This is a three-pronged proposal aimed to address excited state properties in molecules and materials using linear-response TDDFT, real-time electronic dynamics and high-level coupled cluster…

Interaction of Radiolytic Species with Noble Metal Particles in Used Nuclear Fuel

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Frances Skomurski

Project type

Exploratory Research

Noble metal particles (NMP) in used nuclear fuel are nanometer to micron sized alloys of the fission product elements Mo, Tc, Rh, Ru, and Pd. These metals are largely incompatible with the…

Pore-scale Carbon Biogeochemical Processes in Soils and Their Impact to Climate Models

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Chongxuan Liu

Project type

Exploratory Research

Carbon (C) flux from terrestrial soils is an important component in Earth System Models (ESMs) to simulate global carbon cycling and its effect on climate changes. One major challenge to reliably…

Dynamic Bioresponsive Nanomaterials Captured by Dynamic Transmission Electron Microscopy and High Resolution Optical Microscopy

Lead Institution

University of California, San Diego

Principal Investigator

Nathan Gianneschi

Project type

Large-Scale EMSL Research

The overarching goal of this research program is to develop discrete, biomolecule encoded nanomaterials capable of responding to their environment through fundamental changes in their morphological,…

Influence of Mass transfer on Bioavailablility and Kinetic Rate of U(VI) Biotransformation (Liu NABIR-U, PNNL Scope # 45386. Liu NABIR.)

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Chongxuan Liu

Project type

Exploratory Research

Enhance our understanding on the mechanisms that influence uranium bioavailability and kinetic rate of biotransformation in contaminated sediments.

Influence of Microscopic Mass Transfer on the Reactivity and Stability of Uranium

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Chongxuan Liu

Project type

Exploratory Research

This proposed project will investigate microscopic U(VI) mass transfer under influence of biogeochemical reactions in representative Hanford U(VI)-contaminated sediments. Recent research by our group…

Reactions and Transport of Toxic Metals in Rock Forming Silicates at 25C. (Ilton BES-Silicates, PNNL Scope #44552)

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Eugene Ilton

Project type

Exploratory Research

Exploration of the mechanisms of oxidation-reduction reactions at the mineral fluid interface and transport of reactive components along the grain boundary interface in rocks. Work authorization…

Actinide Interactions with Envrionmental Bacteria

Lead Institution

Los Alamos National Laboratory

Principal Investigator

Mary Neu

Project type

Exploratory Research

Bacteria can influence the speciation and resultant mobility of contaminant actinides via a range of direct and indirect mechanisms. We propose to use the electron microscopy resourses and expertise…

CFD Code Performance Testing

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Thomas Michener

Project type

Exploratory Research

The purpose of the Pilot Project request is to perform code conversion and performance testing of the COBRA-SFS and TEMPEST CFD computer codes.

Ultrastructural Properties of SIS

Lead Institution

Cook Biotech Incorporated

Principal Investigator

Abram Janis

Project type

Exploratory Research

Porcine small intestinal submucosa (SIS) is a naturally derived, collagen-based extracellular matrix that has been used extensively in humans as a biomaterial without complication. Scanning electron…