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Aaron Olson

Institution
Seattle Children's Research Institute

Projects

Heart Metabolomics during ventricular unloading

Lead Institution
Seattle Children's Research Institute
Principal Investigator
Michael Portman
Project type
Large-Scale EMSL Research
Extracorporeal membrane oxygenation (ECMO) remains the primary method of long term support after myocardial stunning after cardiac surgery in this age group. ECMO often provides a bridge to recovery…

Thyroid Hormone and Myocardial Substrate Use with Aging

Lead Institution
Seattle Children's Research Institute
Principal Investigator
Michael Portman
Project type
Large-Scale EMSL Research
Thyroid hormone regulates cardiac function through binding to its nuclear receptors (TRs). Classically, the ligand bound receptors in turn bind to response elements and control transcription of key…

Metabolic regulation of O-GlcNAc and cardiac function during hypertrophy

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Ljiljana Pasa-Tolic
Despite treatment advances, half of patients suffering from heart failure die within five years of diagnosis, while those who survive may live with severe disabilities. Cardiac hypertrophy poses a…

Metabolic regulation of O-GlcNAc and cardiac function during hypertrophy

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Ljiljana Pasa-Tolic
Despite treatment advances, half of patients suffering from heart failure die within five years of diagnosis, while those who survive may live with severe disabilities. Cardiac hypertrophy poses a…