Integration of Substrate Oxidation with Protein Synthesis and Cellular Signaling in a Complex Biological System
EMSL Project ID
49688
Abstract
These investigations will explore the complex interactions involved in cellular metabolism, protein synthesis, and cell signaling. We will use complex models to link intra-cellular regulatory networks that control the response of cells to their environment. First, we will perform studies on the neonatal pig heart in vivo. The neonatal heart in particular provides an excellent model for all cell systems as it undergoes rapid growth through cell proliferation and expansion and adapts to quickly to physiological changes. These studies will have broad applications to protein synthesis, cellular signaling and metabolomics extending past our mammalian heart model. Regulation of these pathways is relatively conserved through evolution. Therefore, the defined principles and techniques will be applicable to metabolomics, protein synthesis and cellular signaling in microbes with specific EMSL interest.
Project Details
Start Date
2016-11-18
End Date
2017-09-30
Status
Closed
Released Data Link
Team
Principal Investigator
Team Members
Related Publications
Kajimoto M., M. Nuri, N.G. Isern, I. Robillard Frayne, C. Des Rosiers, and M.A. Portman. 2018. "The Metabolic Response of the Immature Right Ventricle to Acute Pressure Overloading." Journal of the American Heart Association 7, no. 11:Article No. e008570. PNNL-SA-128316. doi:10.1161/JAHA.118.008570