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Michael Portman

Institution
Seattle Children's Research Institute

Projects

Heart Metabolomics during ventricular unloading

Lead Institution
Seattle Children's Research Institute
Principal Investigator
Michael Portman
Project type
Large-Scale EMSL Research
Extracorporeal membrane oxygenation (ECMO) remains the primary method of long term support after myocardial stunning after cardiac surgery in this age group. ECMO often provides a bridge to recovery…

Thyroid Hormone and Myocardial Substrate Use with Aging

Lead Institution
Seattle Children's Research Institute
Principal Investigator
Michael Portman
Project type
Large-Scale EMSL Research
Thyroid hormone regulates cardiac function through binding to its nuclear receptors (TRs). Classically, the ligand bound receptors in turn bind to response elements and control transcription of key…

Cardiac Metabolism and Protein Synthesis during Extracorporeal Life Support

Lead Institution
Seattle Children's Research Institute
Principal Investigator
Michael Portman
Project type
Exploratory Research
Mechanical Circulatory Support (MCS) in the form of cardiopulmonary bypass (CPB) is commonly used for infants and children. Extracorporeal life support (ECLS) also a form of MCS remains the primary…

Thyroid Regulation of Cardiac Metabolism

Lead Institution
Seattle Children's Research Institute
Principal Investigator
Michael Portman
Project type
Capability Research
Thyroid hormone deficiency occurs in adults and children after cardiopulmonary bypass (CPB), and can be responsible for acute and persistent decreases in cardiac performance during the critical…

Cell metabolism and c-Myc-induced growth, proliferation and neoplasia.

Lead Institution
Fred Hutchinson Cancer Research Center
Principal Investigator
Fionnuala Morrish
Project type
Capability Research
Chemical and radiological damage to cells can result in inactivation of tumor suppressors or activation of oncogenes, increasing the risk of cancer. The c-Myc oncogene (Myc) is deregulated in over 50…