Alex Beliaev

Algal Productivity Enhancements by Rapid Screening and Selection of Improved Biomass and Lipid Producing Phototrophs (APEX)

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Erin Bredeweg

This project uses a multi-pronged approach to improve oil content in algae capable of sustaining high areal biomass productivities in outdoor ponds. This includes mutagenesis techniques (EMS, ARTP)…

Genome-enabled studies of key light-dependent metabolic and regulatory switches governing reductant and carbon partitioning in cyanobacteria

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Alex Beliaev

Project type

Large-Scale EMSL Research

The main goal of this proposal is develop and apply an integrated omics approach for systems-level analysis of photosynthetic metabolism in cyanobacteria that will lead to the identification of key…

Understanding genomic underpinnings of high-biomass productivity phenotypes in industrially relevant microalgae

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Alex Beliaev

Project type

FICUS Research

Directed evolution and targeted trait selection remain among the most powerful and successful tools available for attaining the process improvements necessary to enable commercial success in many…

Single-Cell Characterization of Microbiomes via Split-Pool Ligation Transcriptomics

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Alex Beliaev

While single-cell technologies are rapidly becoming a standard for measuring expression in eukaryotic organisms, their utility for prokaryotes is facing substantial technical barriers including…

Harnessing Biomineralization Potential of Metal-Oxidizing Bacteria for REE Synthesis

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Alex Beliaev

Although redox reactions and enzymes participating in the extracellular oxidation of Fe and Mn are identified, little is known about the biomineralization mechanisms that facilitate formation…

FedEx1

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Alex Beliaev

Project type

Exploratory Research

Bacterial strains such as Shewanella oneidensis strain MR-1 are key organisms in the bioremediation of metals due to their ability to enzymatically reduce and precipitate a diverse range of heavy…

Thrust Area 3:Mutagenesis and Functional Characterization of Shewanella oneidensis Genes Involved in Fe(III) and Mn(IV) Oxide Reduction (LDRD #3)

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Alex Beliaev

Project type

Grand Challenge

Although microbial metal reduction has been extensively studied from standpoints of ecology, physiology, genetics and biochemistry, little is known about the molecular mechanisms and pathways of…

Growth analysis in mixed microbial populations using microscopy coupled with computational approaches

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Alex Beliaev

Project type

Large-Scale EMSL Research

Microbial phototroph-heterotroph associations (PHA) are common in nature as they provide basis for many water- and terrestrial-based ecosystems. Metabolic interactions between partners are the…

Genome-Enabled Studies of Photosynthetic Microorganisms for Bioenergy Applications - Chemical Protein Profiling

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Aaron Wright

As part of PNNL's Scientific Focus Area "Genome-Enabled Studies of Photosynthetic Microorganisms for Bioenergy Applications" this project is applying and developing click-chemistry…

EMSL Science Overview

Alex Beliaev

Projects

Algal Productivity Enhancements by Rapid Screening and Selection of Improved Biomass and Lipid Producing Phototrophs (APEX)

Genome-enabled studies of key light-dependent metabolic and regulatory switches governing reductant and carbon partitioning in cyanobacteria

Understanding genomic underpinnings of high-biomass productivity phenotypes in industrially relevant microalgae

Single-Cell Characterization of Microbiomes via Split-Pool Ligation Transcriptomics

Harnessing Biomineralization Potential of Metal-Oxidizing Bacteria for REE Synthesis

FedEx1

Thrust Area 3:Mutagenesis and Functional Characterization of Shewanella oneidensis Genes Involved in Fe(III) and Mn(IV) Oxide Reduction (LDRD #3)

Growth analysis in mixed microbial populations using microscopy coupled with computational approaches

Genome-Enabled Studies of Photosynthetic Microorganisms for Bioenergy Applications - Chemical Protein Profiling