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Erica Saphire

Institution
La Jolla Institute for Immunology
ORCID
ORCID logo 0000-0002-1206-7451

Projects

Structural Analysis of Lineage I Lassa Virus Glycoprotein

Lead Institution
La Jolla Institute for Immunology
Principal Investigator
Erica Saphire
Lassa virus (LASV), the causative agent of Lassa hemorrhagic fever, is endemic in Western Africa, infecting over 100,000 people every year, resulting in roughly 5,000 deaths—yet no vaccines are…

Collaborative Access Team: Pacific Northwest Cryo-EM Center (PNCC)

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
James Evans
PNNL will create and operate the Pacific Northwest Center for Cryo-EM (PNCC), a state-of-the-art national center for cryo-electron microscopy (Cryo-EM) that will rapidly and efficiently collect and…

Broad-spectrum inhibitors of ebolavirus entry

Lead Institution
La Jolla Institute for Immunology
Principal Investigator
Erica Saphire
There are six known viruses in the ebolavirus genus, at least three of which are known to cause severe hemorrhagic fever in humans. All ebolaviruses display one surface protein, a glycoprotein termed…

Medical Defenses Against Emerging Infectious Disease

Lead Institution
La Jolla Institute for Immunology
Principal Investigator
Erica Saphire
Hemorrhagic fever viruses like Ebola, Marburg, and Lassa cause up to 90% lethality. To study these re-emerging threats to human health and develop the needed vaccines and antivirals, our laboratory…