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Fred Heffron

Institution
Oregon Health & Science University

Projects

Identifying Targets for Therapeutic Interventions using Proteomic Technology

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joshua Adkins
Project type
Exploratory Research
This proposal will utilize new comprehensive and quantitative proteomic technologies and related capabilities developed at PNNL to identify targets for therapeutic intervention for Salmonella…

A Systems Biology Approach to Infectious Diseases Research

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joshua Adkins
Project type
Exploratory Research
We describe an integrated program for coupling advanced capabilities in high-throughput transcriptomics, proteomics, and metabolomics with a comprehensive informatics infrastructure and a…

Regulating Space: Bacterial Mastery of the Host Actin Cytoskeleton

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Jason McDermott
Project type
Large-Scale EMSL Research
Abstract: The host plasma membrane, the landscape for environmental and physical perturbations by many microbial pathogens, enhances or diminishes signal transduction by altering diffusivity and…

A Systems Biology Approach to Infectious Diseases Research

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joshua Adkins
Project type
Exploratory Research
We describe an integrated program for coupling advanced capabilities in high-throughput transcriptomics, proteomics, and metabolomics with a comprehensive informatics infrastructure and a…

NMR-based metabolomics of the enteropathogens Salmonella and Yersinia

Lead Institution
Washington State University Tri-Cities
Principal Investigator
Kathleen McAteer
Project type
Large-Scale EMSL Research
The goal of this research is to analyze and reconstruct intercellular and intracellular networks in Salmonella and Yersinia using multiple types of -omics data. Although we hope to gain a more…

Discovery of Host Proteins Involved in Host-Pathogen Interactions

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joshua Adkins
The multiple mechanisms by which pathogenic enterobacteria of the genus Salmonella infect their host indicate a complex host-pathogen relationship. The pathogen secretes dozens of proteins, termed &…

Discovery of Host Proteins Involved in Host-Pathogen Interactions

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joshua Adkins
The multiple mechanisms by which pathogenic enterobacteria of the genus Salmonella infect their host indicate a complex host-pathogen relationship. The pathogen secretes dozens of proteins, termed &…