Justin Teeguarden

Nanoscale Insight into the Living Cell Membrane Responses to Ultrafine PM (Orr LDRD-EBI, PNNL Scope #49989)

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Galya Orr

Project type

Exploratory Research

Ultrafine particulate air pollutants exert harmful effects on human health to a greater extent than other fine particulate matter (PM), and these effects have been linked to the surface properties of…

Computational and Experimental Nanoparticle Dosimetry for nanomaterial Safety

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Justin Teeguarden

Project type

Exploratory Research

Development and deployment of nanomaterial based technologies improving energy and environmental security are high priority research activities for the Department of Energy. Nanomaterial development…

Nanoscale Characterization of Nanomaterial - Cell Interactions

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Galya Orr

Project type

Large-Scale EMSL Research

This proposal is a continuation of research pursued under EMSL User Proposal #17690. The extensive use of amorphous silica nanoparticles (NPs) in the industry, and the growing use of carbon nanotubes…

Addressing Challenges in Nanoscale Characterization

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Daniel Gaspar

Project type

Large-Scale EMSL Research

Nanoscale materials offer the promise of significant advances in fields as diverse as the production, storage and efficient use of energy, sensing and environmental remediation. The characterization…

Physicochemical determinants of distribution and fate of nanoparticles following in vivo exposure

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Justin Teeguarden

Project type

Large-Scale EMSL Research

The risks associated with the use of nanomaterials have been recently under investigation (1) as increasingly more nanosized products are developed and commercialized. The advent of nanotoxicology as…

Quantify cellular and sub-cellular nanoparticle dose for developing predictive models to support accurate dose-response assessments

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Justin Teeguarden

Project type

Large-Scale EMSL Research

Nanomaterials represent a new class of materials with unique physical and chemical properties with the now widely acknowledged potential to enable new technological advancements in multiple…

Characterization of partially soluble copper oxide nanoparticles for evaluating the role of deposited dose rate in respiratory tract target cell responses

Lead Institution

University of Rochester

Principal Investigator

Alison Elder

Project type

Exploratory Research

The increasing use of nanoparticles (NPs < 100 nm in at least one dimension) in industrial settings has led to a greater concern about the potential for human exposures. Although there are several…

Global Forensic Chemical Exposure Assessment for the Environmental Exposome

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Thomas Metz

The absence of methodology for making unique chemical identifications of 100’s or 1000s of chemicals in a single analysis is the most significant obstacle to the global assessment of chemical…

Materials Science Core for NIH Center -Integrating Structure, Activity, Biokinetics and Response for Engineered Nanoparticle (ENP) Risk Assessment

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Donald Baer

This reseach uses EMSL capabilities to synthesize, characterize and deliver well defined nanoparticles for toxicological studies in support of a National Institute of Health Center on the Toxicology…

U.S. Air Force School of Aerospace Medicine and PNNL: Multi-omics for the Screening of Chemical Toxicity

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Justin Teeguarden

The U.S. Air Force School of Aerospace Medicine (USAFSAM), Force Health Protection Branch (FHP) conducts biomedical research and consultation to advance the identification and mitigation of chemical…

EMSL Science Overview

Justin Teeguarden

Projects

Nanoscale Insight into the Living Cell Membrane Responses to Ultrafine PM (Orr LDRD-EBI, PNNL Scope #49989)

Computational and Experimental Nanoparticle Dosimetry for nanomaterial Safety

Nanoscale Characterization of Nanomaterial - Cell Interactions

Addressing Challenges in Nanoscale Characterization

Physicochemical determinants of distribution and fate of nanoparticles following in vivo exposure

Quantify cellular and sub-cellular nanoparticle dose for developing predictive models to support accurate dose-response assessments

Characterization of partially soluble copper oxide nanoparticles for evaluating the role of deposited dose rate in respiratory tract target cell responses

Global Forensic Chemical Exposure Assessment for the Environmental Exposome

Materials Science Core for NIH Center -Integrating Structure, Activity, Biokinetics and Response for Engineered Nanoparticle (ENP) Risk Assessment

U.S. Air Force School of Aerospace Medicine and PNNL: Multi-omics for the Screening of Chemical Toxicity