Materials Science Core for NIH Center -Integrating Structure, Activity, Biokinetics and Response for Engineered Nanoparticle (ENP) Risk Assessment
EMSL Project ID
48689
Abstract
This reseach uses EMSL capabilities to synthesize, characterize and deliver well defined nanoparticles for toxicological studies in support of a National Institute of Health Center on the Toxicology of Nanoparticles. The Material Science Core will support the material and characterization needs of Projects 1, 2, and 3. The efforts of the Material Science Core are organized into three main components: 1) manufacture of primary particles (amorphous silica, cerium, and iron oxides) with specific surface modifications; 2) the modification of the primary particles by addition of fluorescent labels to support tracking and quantification in the biological systems under study, and; 3) characterization of nanoparticles. A major focus of the Material Science Core will be completing characterizations in the most appropriate environment for each use.
Project Details
Start Date
2014-12-10
End Date
2015-09-30
Status
Closed
Released Data Link
Team
Principal Investigator
Team Members
Related Publications
Guide to making XPS measurements on nanoparticles
Baer D.R. 2020. "Guide to Making XPS Measurements on Nanoparticles." Journal of Vacuum Science and Technology A--Vacuum, Surfaces and Films 38, no. 3:Article No. 031201. PNNL-SA-149921. doi:10.1116/1.5141419
All that is silver is not toxic: silver ion and particle kinetics reveals the role of silver ion aging and dosimetry on the toxicity of silver nanoparticles
Smith J.N., D.G. Thomas, H.D. Jolley, V.K. Kodali, M.H. Littke, P. Munusamy, and D.R. Baer, et al. 2018. "All that is Silver is not Toxic: Silver Ion and Particle Kinetics Reveals the Role of Silver Ion Aging and Dosimetry on the Toxicity of Silver Nanoparticles." Particle and Fibre Toxicology 15. PNNL-SA-135829. doi:10.1186/s12989-018-0283-z
An unexpected phase transformation of ceria nanoparticles in aqueous media
Kuchibhatla S.V., A.S. Karakoti, A.E. Vasdekis, C.F. Windisch, S. Seal, S. Thevuthasan, and D.R. Baer. 2019. "An unexpected phase transformation of ceria nanoparticles in aqueous media." Journal of Materials Research 34, no. 3:465-473. PNNL-SA-137435. doi:10.1557/jmr.2018.490
The Chameleon Effect: Characterization Challenges Due to the Variability of Nanoparticles and Their Surfaces
Baer D.R. 2018. "The Chameleon Effect: characterization challenges due to the variability of nanoparticles and their surfaces." Frontiers in Chemistry 6. PNNL-SA-131780. doi:10.3389/fchem.2018.00145
Importance of sample preparation on reliable surface characterisation of nano-objects: ISO standard 20579-4
Baer D.R., A.S. Karakoti, C.A. Clifford, C. Minelli, and W.E. Unger. 2018. "Importance of sample preparation on reliable surface characterisation of nano-objects: ISO Standard 20579-4." Surface and Interface Analysis 50, no. 9:902-906. PNNL-SA-135106. doi:10.1002/sia.6490
Provenance information as a tool for addressing engineered nanoparticle reproducibility challenges
Baer DR, P Munusamy, and BD Thrall. 2016. "Provenance information as a tool for addressing engineered nanoparticle reproducibility challenges." Biointerphases 11(4):Article No. 04B401. doi:10.1116/1.4964867
The pulmonary inflammatory response to multiwalled carbon nanotubes is influenced by gender and glutathione synthesis
Cartwright MM, SC Schmuck, C Corredor, BB Wang, DK Scoville, C Chisholm, HW Wilkerson, Z Afsharinejad, T Bammler, JD Posner, V Shutthanandan, DR Baer, S Mitra, WA Altemeier, and TJ Kavanagh. 2016. "The pulmonary inflammatory response to multiwalled carbon nanotubes is influenced by gender and glutathione synthesis." Redox Biology 9:264-275. doi:10.1016/j.redox.2016.08.009
Gold/silver core-shell 20 nm nanoparticles extracted from citrate solution examined by XPS
Engelhard MH, JN Smith, and DR Baer. 2016. "Gold/silver Core-shell 20 nm Nanoparticles Extracted from Citrate Solution Examined by XPS." Surface Science Spectra 23(1):Article No. 29. doi:10.1116/1.4953792
Quantifying the Impact of Nanoparticle Coatings and Nonuniformities on XPS Analysis: Gold/Silver Core–Shell Nanoparticles
Wang YCA, MH Engelhard, DR Baer, and DG Castner. 2016. "Quantifying the Impact of Nanoparticle Coatings and Non-uniformities on XPS Analysis: Gold/silver Core-shell Nanoparticles." Analytical Chemistry 88(7):3971 - 3925. doi:10.1021/acs.analchem.6b00100