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U.S. Air Force School of Aerospace Medicine and PNNL: Multi-omics for the Screening of Chemical Toxicity


EMSL Project ID
51703

Abstract

The U.S. Air Force School of Aerospace Medicine (USAFSAM), Force Health Protection Branch (FHP) conducts biomedical research and consultation to advance the identification and mitigation of chemical and other hazardous exposures in Air Force Personnel. FHP is expanding capabilities to meet the operational requirements of the U.S. Air Force’s Total Exposure Health Program. USAFSAMs Force Health Protection unit is advancing the use of multiple cell culture systems for screening chemical toxicity. The goal of these toxicity screening studies are to increase the speed of discovering which chemicals pose a threat to operational readiness and health, to identify how the chemicals work to cause adverse effects, and measure biomarkers of toxicity that could be deployed against exposure studies conducted in humans. PNNL will support FHP through the measurement of biological molecules and other chemicals in samples from humans, animals and cell based test-systems using PNNL’s world-class proteomic, metabolomic and lipidomic capabilities. PNNL will perform data analysis and statistics, to identify statistically significant biomarkers of biological response in these toxicity test systems and human exposure studies in an effort to reveal the biological mechanisms of toxicity.

Project Details

Start Date
2020-10-01
End Date
2023-09-30
Status
Closed

Team

Principal Investigator

Justin Teeguarden
Institution
Environmental Molecular Sciences Laboratory

Co-Investigator(s)

Joshua Adkins
Institution
Pacific Northwest National Laboratory