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Joshua Adkins

Institution
Pacific Northwest National Laboratory
ORCID
ORCID logo 0000-0003-0399-0700

Projects

Discovery of Host Proteins Involved in Host-Pathogen Interactions

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joshua Adkins
The multiple mechanisms by which pathogenic enterobacteria of the genus Salmonella infect their host indicate a complex host-pathogen relationship. The pathogen secretes dozens of proteins, termed &…

PNNL Proteomics Chemical Analysis Center for the MoTrPAC (ProMoTr)

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joshua Adkins
Although the health benefits of physical activity in prevention and mitigation of many chronic diseases have been documented for decades, the molecular mechanisms mediating these health benefits are…

A Systems Biology Approach to Infectious Diseases Research

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joshua Adkins
Project type
Exploratory Research
We describe an integrated program for coupling advanced capabilities in high-throughput transcriptomics, proteomics, and metabolomics with a comprehensive informatics infrastructure and a…

Spatial Organization of Methane Oxidation: Rediscovering Fundamentals

Lead Institution
San Diego State University
Principal Investigator
Marina Kalyuzhnaya
Project type
Large-Scale EMSL Research
We rarely think about prokaryotic metabolism as a highly structured system with function-dedicated compartments. It is becoming more apparent that a bag-like representation of microbial metabolism is…

A Molecular Atlas of the Developing Lung

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joshua Adkins
The United States is one of the top nations for prematurely born infants and has a correspondingly high dayone infant mortality rate. Expanding our understanding of alveologenesis is a critical step…

Predictive Modeling of Viral Pathogenesis

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joshua Adkins
The interactions between a host and a pathogen are complex, representing a molecular interplay that results in either health or disease as an outcome. Understanding the nuances of these interactions…

Genomes-to-Life Protein Complex Isolation Capability

Lead Institution
Western University of Health Sciences
Principal Investigator
Thomas Squier
Project type
Exploratory Research
We have established a pilot proteomics facility in support of the "Goal 1" of the Department of Energy's Genomes to Life program, which seeks to identify 80% of the protein complexes…

NMR-based metabolomics of the enteropathogens Salmonella and Yersinia

Lead Institution
Washington State University Tri-Cities
Principal Investigator
Kathleen McAteer
Project type
Large-Scale EMSL Research
The goal of this research is to analyze and reconstruct intercellular and intracellular networks in Salmonella and Yersinia using multiple types of -omics data. Although we hope to gain a more…

Biomarkers for pulmonary injury following deployment

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joshua Adkins
This project is designed to measure the physiological response of Iraq dust inhalation relative to control silica using small RNA and the global protein composition levels in blood serum and broncho…

Predictive Modeling of Viral Pathogenesis

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joshua Adkins
The interactions between a host and a pathogen are complex, representing a molecular interplay that results in either health or disease as an outcome. Understanding the nuances of these interactions…

Proteomic Assessment of Genes of Unknown Function

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joshua Adkins
Understanding the full repertoire of biological functions has proven elusive, hampering our ability to predict outcomes of biological processes, such as infections or impacts of toxins. PNNL will…

Identifying Targets for Therapeutic Interventions using Proteomic Technology

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joshua Adkins
Project type
Exploratory Research
This proposal will utilize new comprehensive and quantitative proteomic technologies and related capabilities developed at PNNL to identify targets for therapeutic intervention for Salmonella…

PNNL Proteomics Chemical Analysis Center for the MoTrPAC (ProMoTr)

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joshua Adkins
Although the health benefits of physical activity in prevention and mitigation of many chronic diseases have been documented for decades, the molecular mechanisms mediating these health benefits are…

Cerebrospinal Fluid Proteome

Lead Institution
University of Medicine and Dentistry, New Jersey Medical School
Principal Investigator
Steven Schutzer
Project type
Exploratory Research
The exact cause of many neurologic diseases remains unknown. Consequently there are no effective treatments. The cerebrospinal fluid (CSF) is a liquid extension of the brain and is likely to contain…

Discovery of Host Proteins Involved in Host-Pathogen Interactions

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joshua Adkins
The multiple mechanisms by which pathogenic enterobacteria of the genus Salmonella infect their host indicate a complex host-pathogen relationship. The pathogen secretes dozens of proteins, termed &…

A Molecular Atlas of the Developing Lung

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joshua Adkins
The United States is one of the top nations for prematurely born infants and has a correspondingly high dayone infant mortality rate. Expanding our understanding of alveologenesis is a critical step…

Biomarkers for pulmonary injury following deployment

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joseph Brown
This project is designed to measure the physiological response of deployment using small RNA and the global protein composition levels in blood serum, urine, and broncho-alveolar lavage fluid (BALF)…

Proteomic Assessment of Genes of Unknown Function

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joshua Adkins
Understanding the full repertoire of biological functions has proven elusive, hampering our ability to predict outcomes of biological processes, such as infections or impacts of toxins. PNNL will…

Preliminary Proteomics of Microbial-Host Systems

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joshua Adkins
In this collaborative study we will analyze and characterize microbial-host interactions using proteomics. The serum of healthy and anthrax-infected macaques will be analyzed to assess qualitatively…

PNNL Proteomics Chemical Analysis Center for the MoTrPAC (ProMoTr)

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joshua Adkins
Although the health benefits of physical activity in prevention and mitigation of many chronic diseases have been documented for decades, the molecular mechanisms mediating these health benefits are…

A Systems Biology Approach to Infectious Diseases Research

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joshua Adkins
Project type
Exploratory Research
We describe an integrated program for coupling advanced capabilities in high-throughput transcriptomics, proteomics, and metabolomics with a comprehensive informatics infrastructure and a…

High Throughput Proteomic Production Operations

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joshua Adkins
This project supports the ongoing operations and capability development for high throughput and quantitative measurements of microbial proteomes along with the informatics capabilities necessary to…

Regulating Space: Bacterial Mastery of the Host Actin Cytoskeleton

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Jason McDermott
Project type
Large-Scale EMSL Research
Abstract: The host plasma membrane, the landscape for environmental and physical perturbations by many microbial pathogens, enhances or diminishes signal transduction by altering diffusivity and…