Sean Colby | Environmental Molecular Sciences Laboratory

Yarrowia lipolytica for biotechnology and synthetic biology

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Erin Bredeweg

The team at PNNL is using a combination of flow cytometry, microscopy and lipidomics/metabolomics to establish baseline cell biological and metabolite data on DNA agility in eukaryotic organisms, and…

Pacific Northwest Advanced Compound Identification Core

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Thomas Metz

The capability to chemically identify thousands of metabolites and other chemicals in clinical samples will revolutionize the search for environmental, dietary, and metabolic determinants of disease…

Pacific Northwest Advanced Compound Identification Core

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Thomas Metz

The capability to chemically identify thousands of metabolites and other chemicals in clinical samples will revolutionize the search for environmental, dietary, and metabolic determinants of disease…

Understanding Biases in Natural Organic Matter FTICR Mass Spectrometry to More
Accurately Model Complex Environmental Systems

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Rosalie Chu

Characterization of natural organic matter (NOM) by direct infusion (DI) Fourier transform mass spectrometry (FTMS) yields rich and complex information about environmental systems. However, the…

Computationally-driven discovery and identification of small molecules in biological systems

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Ryan Renslow

In this project we will build the critical tools for an eventual full standards-free (e.g. computation derived identification libraries) and library-free (i.e. de novo) small molecule identification…

Computationally-driven discovery and identification of small molecules in biological systems

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Jamie Nunez

In this project we will build the critical tools for an eventual full standards-free (e.g. computation derived identification libraries) and library-free (i.e. de novo) small molecule identification…

In silico Chemical Library Engine (ISICLE) for Expo/Metabo-lomics and Modeling

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Ryan Renslow

Currently, there are no nuclear magnetic resonance or IMS databases specifically built for identifying and quantifying metabolites of relevance to environmental samples in general, or to microbial…

FSFA: MOSAIC -- Metabolic and Spatial Interactions in Communities FY18 proposal

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Errol Robinson

This EMSL user proposal is to support the MOSAIC DOE BER funded FSFA at PNNL. The primary activities involving EMSL are a set of BSSD demonstration tasks focusing on key science questions and related…

Prediction of soil microbiome phenotypic responses to changing moisture conditions

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Jason McDermott

The goal of this project is to attain a systems level understanding of the soil microbiome and its phenotypic response to changing moisture through a tractable, spatially explicit examination of the…

Prediction of soil microbiome phenotypic responses to changing moisture conditions

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Jason McDermott

The goal of this project is to attain a systems level understanding of the soil microbiome and its phenotypic response to changing moisture through a tractable, spatially explicit examination of the…

Projects