Sriram Subramaniam

The University of British Columbia

0000-0003-4231-4115

Projects

Collaborative Access Team: Pacific Northwest Cryo-EM Center (PNCC)

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

James Evans

PNNL will create and operate the Pacific Northwest Center for Cryo-EM (PNCC), a state-of-the-art national center for cryo-electron microscopy (Cryo-EM) that will rapidly and efficiently collect and…

Cryo-EM of Metabolic Enzymes for Drug Design

Lead Institution

University of British Columbia

Principal Investigator

Sriram Subramaniam

Given the high failure rate of drug candidates that enter clinical trials and the length of time involved, there is an urgent need to develop new approaches to lower failure rates. Some of the…

Elucidating Native Structures of Enveloped Virus Glycoproteins using Cryo-EM and Tomography

Lead Institution

University of British Columbia

Principal Investigator

Sriram Subramaniam

We seek to understand the entry mechanisms of enveloped viruses for three viral families having broad health impact worldwide: coronaviruses such as SARS CoV 2, retroviruses such as HIV 1, and…