Metabonomic Studies of host response to Yersinia Pestis exposure through analysis of plasma and urine from mice
EMSL Project ID
17809
Abstract
The first goal of this research project is to establish reliable methods for NMR analysis of urine and plasma from mice that lead to interpretable metabonomic data. The second goal is to investigate the common response mechanisms in a mouse animal model to a Yersinis Pestis (Y. pestis) infection by combining the NMR metabonomic data with data from microarray, proteomic and bioinformatics approaches.This proposal is related to the EMSL science theme Biological Interactions and Interfaces as the metabonomic data generated will be complementary to proteomic studies in the Y. pestis-exposed organism. It also aligns with the EMSL mission to provide "integrated experimental and computational resources for discovery and technological innovation in the environmental molecular sciences to support the needs of DOE and the nation" as it is a multidisciplinary approach to understanding pathogenesis which in turn can help develop medical countermeasures to biological warfare agents.
Project Details
Project type
Capability Research
Start Date
2006-05-01
End Date
2006-11-21
Status
Closed
Released Data Link
Team
Principal Investigator
Team Members