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Michael Kennedy

Institution
Miami University

Projects

Protein Interactions and Interfaces

Lead Institution
Rutgers University
Principal Investigator
Gaetano Montelione
Project type
Large-Scale EMSL Research
All proteins interact with other molecules: ligands, metals, membranes, surfaces or other proteins. Such interactions are intrinsic to protein function. We propose to leverage our successful program…

NMR Studies of Nudix proteins from D.radiodurans

Lead Institution
Lawrence Berkeley National Laboratory
Principal Investigator
David Wemmer
Project type
Capability Research
We are in the process of cloning and expressing proteins from D.radiodurans that are involved in various aspects of DNA repair and maintaining DNA integrity. Among these some of the nucleotide…

Structural Proteomics of Myobacterium Tuberculosis

Lead Institution
Los Alamos National Laboratory
Principal Investigator
Thomas Terwilliger
Project type
Capability Research
Project Description: Due to the availability of the complete genome of M. tuberculosis and also in part to our development of a genetic system for studying gene function in M. tuberculosis, our…

Structure of Allochromatium vinosum DsrC protein

Lead Institution
Los Alamos National Laboratory
Principal Investigator
Thomas Terwilliger
Project type
Capability Research
Project Description: The dsrC gene codes for the 12.7 kDa protein DsrC, also known as the gamma subunit of dissimilatory sulfite reductase, and occurs in all sulfate-reducing bacteria (e.g…

Structural Biology of the Human High Mobility Group A (HMGA) Proteins

Lead Institution
Washington State University
Principal Investigator
Raymond Reeves
Project type
Capability Research
HMGA1 proteins play a critical role in the adaptive immune response to infectious microorganisms and viruses, affecting gene regulation that stimulates resting lymphocytes into active T-cells by…

Structural Genomics of Eukaryotic Model Organisms

Lead Institution
Rutgers University
Principal Investigator
Gaetano Montelione
Project type
Capability Research
We have recently received a NIH Center Grant in Structural Genomics establishing the Northeast Structural Genomics Consortium for evaluating the feasibility, costs, economies of scale, and value of…

Structure and Recognition in Microbial Membranes Proteins, and DNA

Lead Institution
Oak Ridge National Laboratory
Principal Investigator
T. Straatsma
Project type
Capability Research
Developments in simulation methodologies as well as computer hardware have enabled the molecular simulation of biological systems of increasing size and with increasing accuracy, providing molecular…

Structural Proteomics of Myobacterium Tuberculosis

Lead Institution
Los Alamos National Laboratory
Principal Investigator
Thomas Terwilliger
Project type
Capability Research
Project Description: Due to the availability of the complete genome of M. tuberculosis and also in part to our development of a genetic system for studying gene function in M. tuberculosis, our…

Structural Studies of Riboswitches

Lead Institution
Miami University
Principal Investigator
Michael Kennedy
Project type
Capability Research
Riboswitches are metabolite-binding domains in certain messenger RNAs that modulate gene expression in response to changing concentrations of metabolites. Riboswitches are composed of two functional…

Structural Proteomics of Myobacterium Tuberculosis

Lead Institution
Los Alamos National Laboratory
Principal Investigator
Thomas Terwilliger
Project type
Capability Research
Project Description: Due to the availability of the complete genome of M. tuberculosis and also in part to our development of a genetic system for studying gene function in M. tuberculosis, our…

NMR Structural Studies of Clustered DNA Damage

Lead Institution
Miami University
Principal Investigator
Michael Kennedy
Project type
Capability Research
The primary objective of this research is to characterize the qualitative and quantitative similarities and differences in repair characteristics between clustered damage sites formed by ionizing…

Structural Genomics of Eukaryotic Model Organisms

Lead Institution
Rutgers University
Principal Investigator
Gaetano Montelione
Project type
Capability Research
The Northeast Structural Genomics Consortium is a NIH-funded pilot project aimed at evaluating the feasibility, costs, economies of scale, and value of structural proteomics. The primary goal of our…

Structural Genomics Collaborative Access Team (CAT)

Lead Institution
Miami University
Principal Investigator
Michael Kennedy
The Structural Genomics CAT will carry out research focused in structural genomics and related research areas with a primary goal of increasing throughput, maximizing efficiency of existing resources…

Structural Proteomics: annotating the genome using 3D structure

Lead Institution
University of Toronto
Principal Investigator
Cheryl Arrowsmith
Project type
Capability Research
We are applying for NMR spectrometer time at EMSL as a continuation of our structural proteomics project and to study two p53 interacting proteins. Structure of these proteins in complex with p53…

Structural Proteomics: annotating the genome using 3D structure

Lead Institution
University of Toronto
Principal Investigator
Cheryl Arrowsmith
Project type
Capability Research
We are applying for NMR spectrometer time at EMSL as a continuation of our structural ^M proteomics. Structural proteomics is based on the premise that a protein's biochemical function is ^M …

Structural Proteomics: annotating the genome using 3D structure

Lead Institution
University of Toronto
Principal Investigator
Cheryl Arrowsmith
Project type
Capability Research
We are applying for NMR spectrometer time at EMSL as a continuation of our structural ^M proteomics. Structural proteomics is based on the premise that a protein's biochemical function is ^M …

High-Throughput Structure Determination of Proteins and Protein Complexes

Lead Institution
Rutgers University
Principal Investigator
Gaetano Montelione
Project type
Large-Scale EMSL Research
The Northeast Structural Genomics Consortium (NESGC, www.nesg.org) is one of four large protein structure production centers supported by the NIH Protein Structure Initiative II (the PSI II). The…