Protein markers to type 1 diabetes progression
EMSL Project ID
48239
Abstract
Type 1 diabetes (T1D) results from autoimmune destruction of insulin-producing pancreatic ?-cells – a long asymptomatic period spanning many months to years. Currently, autoantibodies to islet cell antigens serve to identify those at increased risk for T1D, yet additional biomarkers are desperately in need to indicate this ?-cell destruction process and to help understanding the disease pathogenesis. Built on our previous success in identification of serum markers differentiating T1D from healthy controls, the primary goal of this project is to identify novel markers to progression of T1D for early diagnosis and prognosis of T1D, and to gain additional insights into the pathogenesis of this disease. We will extend our previous biomarker discovery effort to human pancreatic tissues obtained from T1D organ donors, and serial serum samples collected during the progression of T1D for a comprehensive identification of novel proteins and protein isoforms correlated to the progression of this disease. EMSL resources on LC-MS based bottom-up and top-down proteomic analyses are needed for successful accomplishment of the objectives of this proposal.
Project Details
Start Date
2014-01-17
End Date
2014-11-20
Status
Closed
Released Data Link
Team
Principal Investigator
Team Members