Structure of the binding interface between leiomodin and tropomyosin.
EMSL Project ID
49194
Abstract
Cardiac muscle cells contain two types of protein filaments composed of either actin or myosin. The filaments slide past one another and produce force in the heart muscle. For healthy heart functioning, proper control of the filament lengths is absolutely critical. The length of actin filaments in muscles is controlled by few proteins including leiomodin, which function is tropomyosin dependent. Determining the structure of the leiomodin/tropomyosin binding interface will give valuable information on residues responsible for interaction. It will also allow to build a complete 3-dimensional model of the complex formed between actin, TM and Lmod and advance our understanding of the molecular mechanism of regulation of the actin filament length in muscle cells
Project Details
Project type
Limited Scope
Start Date
2016-02-18
End Date
2016-04-19
Status
Closed
Released Data Link
Team
Principal Investigator
Co-Investigator(s)