Evaluation of type 1 diabetes biomarker candidates in plasma samples of the DAISY cohort
EMSL Project ID
51019
Abstract
Type 1 diabetes (T1D) is a devastating disease that reduce the life expectancy by over one decade. Its treatment is based solely on exogenous insulin administration and there is no cure or remission. The disease is characterize by autoimmune response against the pancreatic islets (islet autoimmunity – IA) and progressive destruction of the insulin-producing ? cells. To better understand the disease progression and to develop preventive therapies, it is necessary to accurately predict the progression from IA to T1D. Studies have identified markers for early onset of T1D, but they need to be systematic tested in their capacity of predict the progression from IA to T1D. Here we propose to perform a targeted proteomic analysis of plasma samples from the Diabetes Auto Immunity Study in the Young (DAISY) to validate biomarker candidates as predictors of IA to T1D progression.
Project Details
Start Date
2019-08-01
End Date
2021-09-30
Status
Closed
Released Data Link
Team
Principal Investigator
Co-Investigator(s)