ABPP of Opioid and Sedative Receptors to Improve Medical Countermeasure Development
EMSL Project ID
51814
Abstract
This EMSL Resource Owner proposal seeks to utilize Orbitrap MS capabilities for advancing our understanding of opioid and sedative exposures, which could lead to developing safe and efficacious medical countermeasures (MCMs). A DTRA proposal lead by Dr. Aaron Wright was recently funded in this regard. Opioid and sedative exposures requires a much-improved understanding of the identity, abundance, and tissue-specific distribution of receptors in humans and animal models. Identifying and quantifying sensitivity of both known ‘canonical’ and novel ‘non-canonical’ (e.g., off-target) receptors to opioids and sedatives will provide a route to new MCM development. Points of convergence in which receptors bind to multiple opioids and/or sedatives can be used as a focus for broad-spectrum MCM development. Our profiling technology, ABPP, is uniquely suited to reveal known and novel receptor targets by quantitatively characterizing individual receptor responses in tissues and blood.
Project Details
Start Date
2021-01-25
End Date
2023-09-30
Status
Closed
Released Data Link
Team
Principal Investigator
Co-Investigator(s)
Team Members