Projects

Ubiquitin Signaling and Bacterial Effector Proteins

Lead Institution

University of Washington

Principal Investigator

Peter Brzovic

Project type

Large-Scale EMSL Research

In plants and animals post-translational modification of proteins by ubiquitin (Ub) is a regulatory process that impacts nearly every aspect of eukaryotic cell biology. Diverse pathways including,…

Fundamental Studies of the Interaction of Pd and Rh Particles with Ceria and Ceria-Zirconia Surfaces in Model Planar atalysts

Lead Institution

University of Michigan

Principal Investigator

Xiaoqing Pan

Project type

Large-Scale EMSL Research

Ceria and ceria-based oxides have been widely investigated as electronic promoters of activity, selectivity, and thermal stability in a variety of catalysts. Pd on ceria-based supports is an…

Molecular Interactions and Dynamics at Solid Electrolyte Interfaces

Lead Institution

State University of New York at Binghamton

Principal Investigator

Howard Wang

Project type

Large-Scale EMSL Research

We will carry out a systematic study on molecular interactions and dynamics at solid electrolyte interfaces (SEIs) of Li-ion batteries using primarily in situ quantitative nonlinear optical…

Molecular-level Investigation of Dissolved and Stabilized Organic Carbon in Soil

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

James Amonette

Project type

Large-Scale EMSL Research

Soils contain large amounts of organic carbon (OC) and serve as both sources and sinks for atmospheric C. However, little is known about the structural chemistry of stabilized soil OC or the…

Biomineralization and Biosequestration Mechanisms at Lifes Upper Temperatures: A Reappraisal using Novel CryoEM Techniques

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Sherry Cady

Project type

Large-Scale EMSL Research

Given that (i) hyperthermophilic and thermophilic biofilms were some of the earliest microbial communities to inhabit our planet, (ii) such communities evolved and thrived in heavy metal-rich…

Looking for Partners in Crime: Identification of Protein Complexes and Post-Translational Modifications Associated with Drug-Resistance in Breast Cancer

Lead Institution

Erasmus University Medical Center, Rotterdam

Principal Investigator

Arzu Umar

Project type

Large-Scale EMSL Research

Drug resistance of metastatic tumor cells is the major cause of death in breast cancer patients. Through a previous EMSL collaboration, EMMPRIN (extracellular matrix metalloproteinase inducer) was…

Phosphoproteomics of Nuclear Pore Disassembly and Reassembly during Mitosis

Lead Institution

The Ohio State University

Principal Investigator

Stephen Osmani

Project type

Large-Scale EMSL Research

Eukaryotic cells segregate DNA equally to daughter cells during mitosis. Although mitosis is well characterized, its regulation is still poorly understood. The most extensive and least understood…

Adsorption of highly functional oxygenates on metal surfaces

Lead Institution

University of Colorado at Boulder

Principal Investigator

James Medlin

Project type

Large-Scale EMSL Research

This proposal is aimed at conducting computational studies to investigate the surface chemistry of functional alcohols on Pd(111) and related surfaces. Such alcohols are key intermediates in the…

Characterization of Energy Storage Systems Using In Situ and Ex Situ Nuclear Magnetic Resonance Spectroscopy

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Jian-zhi Hu

Project type

Large-Scale EMSL Research

Fundamental research in stationary battery has been limited and an in-situ NMR method to probe transient electrochemical reactions has yet to be developed. We propose to develop unique in situ NMR…

Correlated Structure and Dynamics of Ions and Water at Mineralogical Solid-Water Interfaces

Lead Institution

St. Mary's College of Maryland

Principal Investigator

Geoffrey Bowers

Project type

Large-Scale EMSL Research

The objective of this work is to gain new insight into fundamental processes that occur at solid-fluid interfaces by performing a detailed, molecular-scale study of cation and H2O behavior at…

W-band pulsed EPR: a) probing 17O ligands in the Mo(V) site of sulfite oxidases; b) ascertaining the long distance limit in Pulse Dipolar Spectroscopy of Gd(III) labeled macrobiomolecules.

Lead Institution

University of Arizona

Principal Investigator

John Enemark

Project type

Large-Scale EMSL Research

Abstract W-band pulsed EPR: a) probing 17O ligands in the Mo(V) site of sulfite oxidases; b) ascertaining the long distance limit in Pulse Dipolar Spectroscopy of Gd(III) labeled macrobiomolecules…

Double Heterojunction Organic Hybrid Electrodes and Interfacial Charge Transfer Characterizations Using Novel Optical Spectroscopy Techniques

Lead Institution

University of Alabama

Principal Investigator

Shanlin Pan

Project type

Large-Scale EMSL Research

Hybrid OPVs promise to be efficient and cheap devices to convert solar energy to electricity in comparison with their inorganic and organic counterparts. A hybrid OPV, however, has limited efficiency…

Chemical characterization of organic and biogenic atmospheric aerosol particles and their potential to initiate ice crystal formation

Lead Institution

State University of New York at Stony Brook

Principal Investigator

Daniel Knopf

Project type

Large-Scale EMSL Research

Atmospheric aerosol particles can affect the environment by changing the global radiative budget, increasing air pollution and impacting air quality with subsequent consequences for health related…

Vegetation Influences on Long-Term Carbon Stabilization in Soils: A Continuation of Previous Research

Lead Institution

Lawrence Berkeley National Laboratory

Principal Investigator

Margaret Torn

Project type

Large-Scale EMSL Research

This project is a continuation of our previous research that investigates the influence of vegetation on long-term carbon stabilization in soils using molecular level analysis. Previously, we have…

Critical interface properties of metalorganic species of technological and fundamental importance.

Lead Institution

Washington State University

Principal Investigator

Kerry Hipps

Project type

Large-Scale EMSL Research

This project focuses on in depth fundamental understanding of the interfaces of metalorganic films. As a model for porphyrins, phthalocyanines, and other technologically important metalorganics, we…

Solid state NMR investigations of phosphate sequestration by modified clays and inorganic (oxy) hydroxides

Lead Institution

University of Southern Denmark, Odense

Principal Investigator

Ulla Gro Nielsen

Project type

Large-Scale EMSL Research

Phosphate, which is extensively used as a fertilizer and a detergent additive, is leached into fresh water bodies causing algae bloom and subsequent oxygen deficiency, especially in lakes. Two of the…

Development of a systems-level model of cellular dynamics in response to different environmental conditions in cyanobacteria

Lead Institution

Purdue University

Principal Investigator

Louis Sherman

Project type

Large-Scale EMSL Research

This proposal will utilize a systems biology approach to develop a knowledgebase of the metabolic and regulatory networks that can ultimately be used for the photobiological production of advanced…

Internalization and Fate of Engineered Nanomaterials in Developing Zebrafish Embryos

Lead Institution

Oregon State University

Principal Investigator

Robert Tanguay

Project type

Large-Scale EMSL Research

The growing commerce in micro- and nanotechnology is expected to increase human exposure to submicrometer and nanoscale particles. Adverse effects of these particles on living systems have been…

Cellular Interactions and Fate of Engineered Nanomaterials in Alveolar Epithelial Cells at the Air-Liquid Interface

Lead Institution

Oregon State University

Principal Investigator

Bettye Maddux

Project type

Large-Scale EMSL Research

The growing commerce in micro- and nanotechnology is expected to increase human exposure to submicrometer and nanoscale particles. Adverse effects of these particles on living systems have been…

Nanoparticle design, synthesis and characterization for NIH Center Integrating Structure, Activity, Biokinetics and Response for Engineered Nanoparticle (ENP) Risk Assessment

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Donald Baer

Project type

Large-Scale EMSL Research

This work provides the essential materials science base for designing, synthesizing and delivering three types of nanoparticles for three mechanistic nanotoxicology related biological studies being…