Projects

Regulating Space: Bacterial Mastery of the Host Actin Cytoskeleton

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Jason McDermott

Project type

Large-Scale EMSL Research

Abstract: The host plasma membrane, the landscape for environmental and physical perturbations by many microbial pathogens, enhances or diminishes signal transduction by altering diffusivity and…

Spectroscopic studies of ambiphilic molecular complexes. Activation of small molecules with non-transition metal catalysis

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Thomas Autrey

Project type

Large-Scale EMSL Research

This project will provide fundamental insight into the catalytic activation and transformation of small molecules, e.g., H2, CO2, N2, CH4, by non-metal Lewis pairs in condensed phase environments…

Bioinspired electrocatalysts for small molecule activation.

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Wendy Shaw

Project type

Exploratory Research

The proposed EMSL research is in support of three DOE Basic Energy Sciences research programs that focus on the development of new classes of electrocatalysts for important energy storage and energy…

Nanoparticle / PDMS-based Microfluidic Device for Environmental Monitoring

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Jun Wang

Project type

Exploratory Research

This proposal is to develop nanoparticle-based microfluidic chips for multiplexed detection of environmental biomarkers. We will choose the poly(dimethylsiloxane) (PDMS) to fabricate the microfluidic…

Quantification of Reactive Surface Area of Shales from a Hillslope via 19F MAS NMR of a Fluorine-Containing Probe Molecule

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Karl Mueller

Project type

Large-Scale EMSL Research

To understand natural processes such as nutrient and contaminant cycling as well as carbon sequestration, the rates of regolith formation from rocks and subsequent weathering into secondary minerals…

Characterize the Thermodynamic Forces of Decomposing a Cellulose Microfibril

Lead Institution

University of California, Berkeley

Principal Investigator

Jhih-Wei Chu

Project type

Exploratory Research

To develop viable technologies for the enzymatic decomposition and conversion of cellulosic materials into fuels, mechanistic understanding of the molecular processes that are involved is in urgent…

The Spatial and Chemical Diversity of a Model Microbial Ecosystem by a Combination of Metabolomics and NMR Imaging

Lead Institution

University of California, Berkeley

Principal Investigator

Jillian Banfield

Project type

Large-Scale EMSL Research

Mixed microbial communities drive many key biogeochemical processes, but the mechanisms by which microbial species interact, as well as and the relationship between these interactions and community…

Molecular Interfaces to Single-crystal Anatase Surfaces:
Surface Chemistry and Impact on Charge Dynamics

Lead Institution

University of Wisconsin, Madison

Principal Investigator

Robert Hamers

Project type

Large-Scale EMSL Research

The anatase form of TiO2 is of great interest as a substrate for a variety of photochemical and photoelectrochemical pathways for solar-to-electrical and solar-to-fuel conversion. The resulting…

Molecular Level Understanding of Dissociation of Radical Cationic Glycosylated and Phosphorylated Peptides: Energetics, Dynamics and Mechanisms

Lead Institution

The University of Hong Kong

Principal Investigator

Ivan Chu

Project type

Large-Scale EMSL Research

The goal of this proposed project is to achieve a fundamental understanding of the mechanisms, energetics, and kinetics of specific dissociation pathways of the radical cations of post…

Analysis of Photo-crosslinking Sites of Antagonists and Agonists in CCR5 and CXCR4

Lead Institution

Montana State University

Principal Investigator

Edward Dratz

Project type

Large-Scale EMSL Research

The primary objective of our proposed studies are to characterize the residues on CCR5 and CXCR4 (likely to be deep within biological membranes) that directly mediate the interactions with agonist…

Theoretical Study of the Structure and Reactivity of Vanadia Supported on Defected Anatase TiO2 Surface

Lead Institution

University of California, Berkeley

Principal Investigator

Alexis Bell

Project type

Large-Scale EMSL Research

Modeling of reactions catalyzed by supported vanadia is attracting a lot of attention worldwide. The vanadia models used for such research are built on a number of assumptions about its structure and…

Phosphorus cycling at mineral-water interface: role of mineral dissolution and transformation

Lead Institution

Yale University

Principal Investigator

Ruth Blake

Project type

Large-Scale EMSL Research

Phosphorous (P) is an essential but limiting nutrient for all live forms. Mineral bound PO4 is conditionally available to (micro)organisms depending on the mineral properties, type of bonding…

Proposal for Development of Mass Closure via PNNL PESA for Continuous Fine, Very fine, and Ultra-fine Aerosol Sampling for Health Impact Studies

Lead Institution

University of California, Davis

Principal Investigator

Thomas Cahill

Project type

Exploratory Research

"One of the most urgent needs for future progress in reducing the substantial impacts of ambient air particulate matter (PM) on human health is to determine which of the components are having…

Structure-Property and Interfacial Relationships in Thin Film Energy Conversion Materials and Coatings

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Dean Matson

Project type

Large-Scale EMSL Research

We propose to use of EMSL surface analysis, electron microscopy, laser spectroscopy and other analytical capabilities to characterize nanoscale organic and inorganic materials and hybrid thin film…

Early Transition Metal Oxides as Catalysts: Crossing Scales from Clusters to Single Crystals to Functioning Materials

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Charles Peden

Project type

Large-Scale EMSL Research

Current commercial heterogeneous catalysts are structurally and chemically complex and measurements on them can seldom be interpreted with atomic-level precision. This is especially so for supported…

Global measurments of phosphopeptides in human mammary epithelial cells.

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Richard Zangar

Project type

Exploratory Research

There is a need to understand fundamental regulatory mechanisms that regulate cell growth and differentiation in breast cells. This information can lead to new routes of treating or preventing…

Correlation of Structure and Function of Zinc Metalloproteins Via a Combined NMR/Molecular Theory Approach

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Andrew Lipton

Project type

Large-Scale EMSL Research

One of the most significant challenges in the metallobiochemistry of Zn2+ is the a priori determination of how the metal center will facilitate a particular chemical reaction. Two examples…

Deployment of EMSL Instruments during the 2010 Carbonaceous Aerosol and Radiative Effects Study (CARES)

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Rahul Zaveri

Project type

Exploratory Research

The Carbonaceous Aerosol and Radiative Effects Study (CARES) will be conducted during summer 2010 in order to investigate the evolution of carbonaceous aerosols of different types and their optical…

Preliminary work on the Proteomes of Brains and Dissected Brains Obtained from Control Mice and Treated Mice Simulating Parkinson?s Disease

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

David Camp

Project type

Exploratory Research

Research on the three-dimensional transcriptome of voxelated mice brains has demonstrated that significant RNA expression differences are detectable when comparing the brain transcriptomes of…

Modeling complex bacterial cell systems through development of segregated models with spatial localization

Lead Institution

Oregon State University

Principal Investigator

Brian Wood

Project type

Exploratory Research

Systems of cells can exhibit behavior that is more complex than is expressed by individuals within the population. An example here might the be the formation of biofilms on surfaces. Because of the…