Projects

Thyroid Hormone and Myocardial Substrate Use with Aging

Lead Institution

Seattle Children's Research Institute

Principal Investigator

Michael Portman

Project type

Large-Scale EMSL Research

Thyroid hormone regulates cardiac function through binding to its nuclear receptors (TRs). Classically, the ligand bound receptors in turn bind to response elements and control transcription of key…

High resolution mass spectrometry of high molecular weight compounds formed via the heterogeneous reaction of OH with simple organic aerosols

Lead Institution

Lawrence Berkeley National Laboratory

Principal Investigator

Kevin Wilson

Project type

Large-Scale EMSL Research

Our objective is to determine the fundamental reaction rates and mechanisms for the heterogeneous oxidation of organic aerosols by OH radicals. Single component organic aerosols particles are used…

Ferromagnetic study of ZnO based heterojunctions

Lead Institution

Portland State University

Principal Investigator

Nadarajah Athavan

Project type

Large-Scale EMSL Research

The search for spintronics materials that combine semiconducting and ferromagnetic properties, dilute magnetic semiconductors (DMS), is presently one of the most relevant fields in magnetism…

Chemistry of Aerosols in the North Slope of Alaska: ISDAC 2008 study.

Lead Institution

Lawrence Berkeley National Laboratory

Principal Investigator

Mary Gilles

Project type

Large-Scale EMSL Research

The ISDAC (Indirect and Semi-Direct Aerosol Campaign) field study carried out in the North Slope of Alaska 2008 was a collaborative effort sponsored by the DOE Atmospheric Radiation Measurement (ARM)…

Determination of enhanced ZnO nucleation and growth by modeling, simulation and MOCVD under UV irradiation

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Vincent Woods

Project type

Large-Scale EMSL Research

ZnO is a wide-band-gap semiconductor with band gap energy, Eg, of 3.37 eV at room temperature. It possesses a large exciton binding energy of 60 meV. Considerable excitement has been associated with…

Understanding the dynamics of the cyclophilins family of enzymes and their interactions with their CD147 receptor.

Lead Institution

University of Colorado at Denver

Principal Investigator

Elan Eisenmesser

Project type

Large-Scale EMSL Research

Enzyme motions associated with catalysis have been found to occur even in the absence of substrates and localize to similar regions. This inherent flexibility may allow important conformations to be…

Pathways and fate of individual nanoparticles in vivo; a whole organism approach

Lead Institution

Oregon State University

Principal Investigator

Robert Tanguay

Project type

Large-Scale EMSL Research

The growing commerce in micro- and nanotechnology is expected to increase human exposure to submicrometer and nanoscale particles, including certain forms of amorphous silica nanoparticles. Adverse…

Tissue distribution and fate of nanoparticles following in vivo exposure

Lead Institution

Procter and Gamble

Principal Investigator

Katherine Sarlo

Project type

Large-Scale EMSL Research

The growing commerce in micro- and nanotechnology is expected to increase human exposure to submicrometer and nanoscale engineered particles. Adverse effects of submicrometer and nanoscale particles…

POSTTRANSLATIONAL MODIFICATIONS FOR EARLY DETECTION OF BREAST CANCER

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Richard Zangar

Project type

Large-Scale EMSL Research

Breast cancer is the most common cancer in women and is the second leading cause of death due to cancer. The goal of this study is to use proteomics to identify post-translational modifications …

EFFECT OF STRUCTURE AND IMPURITIES ON CHARGE TRANSFER REACTIONS IN SOLID STATE ELECTROCHEMICAL DEVICES

Lead Institution

Boston University

Principal Investigator

Srikanth Gopalan

Project type

Large-Scale EMSL Research

Interfaces between solid state electrodes, electrolytes, and the gas phase play an important role in the functioning of many solid state electrolyte devices. In actual devices, porous electrodes are…

Photoemission Electron Microscopy of Small Polaron Formation on NaCl Islands on Cu (111)

Lead Institution

University of Minnesota

Principal Investigator

Xiaoyang Zhu

Project type

Large-Scale EMSL Research

Our recent paper describes the time-dependence of small polaron formation at the interface of a metal insulator system. This result is unique in that the observed interfacial polaron formation has…

Investigation of Water-Soluble X-ray Luminescence Nanoparticles for Biomedical Applications

Lead Institution

The University of Texas at Arlington

Principal Investigator

Wei Chen

Project type

Large-Scale EMSL Research

We propose to synthesize and study novel scintillation nanoparticles for use in a relatively new biomedical application termed photodynamic therapy (PDT). Scintillation nanoparticles can emit…

Fluid Spreading on Micro-Patterned Surfaces

Lead Institution

Oregon State University

Principal Investigator

Maria Dragila

Project type

Large-Scale EMSL Research

It is well known that surface micro-texture (e.g., roughness) affects the wetting properties of a solid. The goal of this project is to provide the engineering community with the means to a priori…

Nanoparticle-Cell Interactions and Intracellular Fate; Roles of Particle Surface Properties

Lead Institution

Oregon State University

Principal Investigator

Bettye Maddux

Project type

Large-Scale EMSL Research

The growing commerce in micro- and nanotechnology is expected to increase human exposure to submicrometer and nanoscale particles, including certain forms of gold and amorphous silica. Adverse…

Surface Chemistry of Nanocrystalline Zeolites Probed by Magnetic Resonance Techniques

Lead Institution

University of Iowa

Principal Investigator

Sarah Larsen

Project type

Large-Scale EMSL Research

Nanocrystalline zeolites (with crystal sizes of less than 50 nm) are versatile, porous nanomaterials with potential applications in a broad range of areas including bifunctional catalysis, drug…

Airborne Measurement of Dimethylsulfide, Isoprene, and other Trace Volatile Organic Compounds using a Proton Transfer Reaction Mass Spectrometer during the 2008 DOE ASP VOCALS Field Campaign

Lead Institution

Brookhaven National Laboratory

Principal Investigator

Yin-Nan Lee

Project type

Large-Scale EMSL Research

This proposal requests the participation of EMSL scientist Dr. M. Lizabeth Alexander as a collaborator to deploy on the DOE G-1 aircraft a state-of-the-art volatile organic compound instrument, the…

Catalytic Studies of Transition Metal Oxide Monolayers Supported on Metal Single Crystal Surfaces

Lead Institution

Southern Illinois University

Principal Investigator

Qingfeng Ge

Project type

Large-Scale EMSL Research

Current commercial heterogeneous catalysts are structurally and chemically complex and measurements on them can seldom be interpreted with atomic-level precision. This is especially true for…

Integrated top-down and bottom-up proteomics strategy to identify multisite and multistep modifications on radiation sensitive proteins

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

David Stenoien

Project type

Large-Scale EMSL Research

In order for a cell to mount the appropriate response to a stimulus such as radiation, it must have the necessary biosensors capable of assessing inputs from multiple intracellular and extracellular…

Heterogeneous Ice Nucleation from Biomass Burning Particles: The Effect of Chemical
Composition and Chemical Aging

Lead Institution

State University of New York at Stony Brook

Principal Investigator

Daniel Knopf

Project type

Large-Scale EMSL Research

Organic material is ubiquitous in atmospheric particles. This proposal focuses on potential ice nucleation (IN) activity of biomass burning aerosol (BBA). Biomass burning is a major source of gases…

Multidimensional High-Field Magic-Angle Spinning NMR
of Membrane and Nanocrystalline Proteins

Lead Institution

University of Illinois at Urbana-Champaign

Principal Investigator

Chad Rienstra

Project type

Large-Scale EMSL Research

We aim to extend ongoing studies of membrane and fibril protein structure at the University of Illinois, conducted on 500 and 750 MHz instruments in 3.2 mm magic-angle spinning rotors, to the 900 MHz…