Biocompatible, Engineered Surfaces of Mixed Chemistry
EMSL Project ID
19816
Abstract
High resolution in situ spatial imaging is critical to visualizing how molecules adsorb and arrange themselves on surfaces. In order to image proteins or organic molecules on surfaces, scanning probe methods are often utilized. For many relevant systems, non-conductive substrates necessitate the need for atomic force microscopy, however, nearly all current generation systems are incapable of achieving true atomic resolution in solution using intermittent contact methods. By instituting improvements to reduce instrument noise, it is now possible to achieve true atomic scale imaging of molecules adsorbed to surfaces. Such capabilities can have dramatic impacts in numerous fields such as biocatalysis, protein/biomaterial interactions, biogeochemistry, and molecularly organized surfaces. We propose to utilize a low noise high resolution AFM to characterize mixed chemistry, engineered biointerfaces at very small length scales, in an effort to control and predict the response of the host organism to a biomaterial.
Project Details
Project type
Large-Scale EMSL Research
Start Date
2006-10-02
End Date
2007-10-04
Status
Closed
Released Data Link
Team
Principal Investigator