Projects

Preparation of Novel Catalysts using Ion Soft-Landing

Lead Institution

National Dong Hwa University

Principal Investigator

Wen-Ping Peng

Project type

Large-Scale EMSL Research

Soft landing of low energy gas-phase ion beams onto suitable substrates is a powerful preparative technique with many potential applications. Various classes of compounds (e.g. proteins, metal…

Morphology, Composition and Surface Properties of Novel Functional Multimetallic and Core-shell Nanoparticles and Assemblies

Lead Institution

State University of New York at Binghamton

Principal Investigator

Chuan-Jian Zhong

Project type

Large-Scale EMSL Research

This proposal focuses on the utilization of the EMSL User facilities for the investigation of Morphology, Composition and Surface Properties of Novel Multimetallic Alloy and Core-shell Nanoparticles…

Biogeochemical Processes Responsible for the Enhanced Transport of Plutonium under Transient Unsaturated Condtions.

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Ravi Kukkadapu

Project type

Large-Scale EMSL Research

Plutonium is an element of concern because of its radiotoxicity. At Savannah River Site (SRS), as a result of processing Pu for nuclear weapons, some ~60 Ci of 238Pu and 239Pu was released into…

Identification of Precipitates and Chemistry of Interfaces in Optical Materials

Lead Institution

Washington State University

Principal Investigator

David Bahr

Project type

Large-Scale EMSL Research

This proposal is focused on using EMSLs advanced characterization tools, particularly the recent FIB/SEM instrument, to conclusively identify second phase precipitates and grain boundary adsorbates…

A proteomic analysis of the effects of environmental factors on hydrogen production in the cyanobacterium Anabaena variabilis.

Lead Institution

University of Missouri - St. Louis

Principal Investigator

Teresa Thiel

Project type

Large-Scale EMSL Research

The filamentous cyanobacterium, Anabaena variabilis, produces hydrogen from water, using sunlight as the energy source and carbon dioxide as the carbon source. Hydrogen is made in specialized cells…

The proteome of prostate cancer-derived exosomes: Exosomes as biomarker treasure chests

Lead Institution

Erasmus University Medical Center, Rotterdam

Principal Investigator

Guido Jenster

Project type

Large-Scale EMSL Research

Prostate cancer (PCa) is the most common cancer and the second leading cause of cancer death in men. Although considerable progress in the clinical setting has been made in the past decades, early…

Solid-State NMR Structural Studies of HIV-1 CA Protein Assembly

Lead Institution

University of Delaware

Principal Investigator

Tatyana Polenova

Project type

Large-Scale EMSL Research

This is an application in response to the proposal call "Science Theme: Biological Interactions and Dynamics". We request standard, general non-proprietary access to the 900 MHz solid-state…

Mechanisms of nanocrystalline uraninite oxidation by iron minerals under of sulfate-reducing bacteria

Lead Institution

South Dakota School of Mines and Technology

Principal Investigator

Rajesh Sani

Project type

Large-Scale EMSL Research

Uranium (U) is the most common radionuclide in soils, sediments, and groundwater at many sites including U.S. DOE sites and is therefore of particular environmental concern. Subsurface bacteria such…

Comprehensive Analysis Of Post-Translational Modifications (PTMs) In Proteins Involved In Histone Pre-mRNA Processing By High Performance nanoLC-MS

Lead Institution

University of North Carolina

Principal Investigator

Roopa Thapar

Project type

Large-Scale EMSL Research

All eukaryotic mRNAs undergo a series of posttranscriptional processing events that lead to the generation of a mature mRNA transcript which is then translated. These pre-mRNA processing steps…

Structural basis of the lysis clock in bacteriophages: the holin-antiholin interaction of phage lambda

Lead Institution

Texas A&M University

Principal Investigator

Christian Hilty

Project type

Large-Scale EMSL Research

Bacteria are the most abundant organisms in the biosphere, and, after cell division, the second most common fate of bacterial cells is lysis by bacteriophage. For most bacteriophages, the duration…

Proteomic Analysis of Extracellular Appendages Displayed in Desulfovibrio vulgaris

Lead Institution

Oak Ridge National Laboratory

Principal Investigator

Dwayne Elias

Project type

Large-Scale EMSL Research

Sulfate-reducing bacteria makeup a substantial portion of subsurface microbial communities at DOE contaminated sites in particular. They are capable of reducing and immobilizing, soluble U(VI) by…

Phosphoproteomic profiling of breast cancer cell lines

Lead Institution

Erasmus University Medical Center, Rotterdam

Principal Investigator

Arzu Umar

Project type

Large-Scale EMSL Research

Breast cancer is a very heterogeneous disease, consisting of different molecular subtypes. Effective, targeted treatment is available for estrogen receptor (ER) and human epidermal growth factor…

Abiotic reduction of U(VI) by sorbed Fe(II) and the implications for field-scale bioremediation at the Rifle IFC project site

Lead Institution

US Geological Survey, Menlo Park

Principal Investigator

Kate Campbell

Project type

Large-Scale EMSL Research

Bioremediation of uranium-contaminated sites has recently been explored as a potentially effective groundwater treatment option. The injection of an organic carbon substrate such as acetate…

Simultaneous Optical & Chemical Measurements of Aerosols as a Function of Relative Humidity: Bridging Laboratory and Field Measurements to Models

Lead Institution

Los Alamos National Laboratory

Principal Investigator

Manvendra Dubey

Project type

Large-Scale EMSL Research

Interactions of anthropogenic aerosols with solar radiation and clouds and are the largest source of uncertainty in climate change science. The key science gap is a lack of process-level knowledge…

The Influence of different Fe(III) Phases and the Effect of Sulfate Reduction on the Simultaneous Bioreduction of Iron and Uranium

Lead Institution

Princeton University

Principal Investigator

Peter Jaffe

Project type

Large-Scale EMSL Research

Biostimulation of Fe(III) and/or sulfate reducing microorganisms by addition of acetate can effectively reduce U(VI). However, U(VI) removal from groundwater was hindered in field trials at the…

Probing the Reactivity of Organic Particles Using Ion Soft-Landing

Lead Institution

University of California, Irvine

Principal Investigator

Sergey Nizkorodov

Project type

Large-Scale EMSL Research

Formation and atmospheric processing of particulate matter is one of the focus areas emphasized by EMSL. Organic coatings on atmospheric aerosols determine the surface chemistry that particles…

Scanning and Transmission Electron Microscopy of Grape Berry Shrivel

Lead Institution

Washington State University Tri-Cities

Principal Investigator

Bhaskar Bondada

Project type

Large-Scale EMSL Research

The state of Washington is the second largest producer of premium wine in the nation and is ranked among the worlds top wine regions. Washington wines are found nationally in all 50 states and…

Proteomic-based analysis of components involved in Human cytomegalovirus US28-induced cellular migration

Lead Institution

Oregon Health & Science University

Principal Investigator

Daniel Streblow

Project type

Large-Scale EMSL Research

Our goal is to identify the molecular mechanisms involved in Pyk2 signaling in response to activation by the Human cytomegalovirus (HCMV)-encoded chemokine receptor US28. We propose to utilize…

Fundamental Studies of Nitrogen Oxide Surface Chemistry: A Model System Approach Combining Experiments and Theory

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Janos Szanyi

Project type

Large-Scale EMSL Research

This program is aimed at the development of a fundamental understanding of catalytic nitrogen oxide (NOx) chemistry on base metal oxide surfaces. Special emphasis is on identifying new and unique…

Modeling charge transport and interfacial chemistry at the nanoscale

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Ram Devanathan

Project type

Large-Scale EMSL Research

Understanding charge transfer, charge transport and molecular transport in nanomaterials and interfaces in solids (such as grain boundaries, interfaces in multilayer materials, and hydrophilic…