Projects

As a scientific user facility, the Environmental Molecular Sciences Laboratory (EMSL) provides expertise, instrumentation, and resources to 250 projects each year.

EMSL projects displayed on the EMSL web site project page reflect project abstracts and information migrated to this page before April 30, 2024. To review current and past EMSL user projects, visit EMSL Science Central.™

Elucidating the molecular mechanism of gut microbiome response to the Specific Carbohydrate Diet in pediatric patients with inflammatory bowel disease

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

William Nelson

Pediatric Inflammatory Bowel Disease (IBD) is a debilitating condition that includes ulcerative colitis (UC) and Crohn's disease (CD). It affects 1.4 million children and adults in the US, at an…

Determination of Iron Species in Iron-Enriched Compost used to Attenuate Arsenic in Contaminated Soil

Lead Institution

Washington State University

Principal Investigator

James Harsh

Project type

Limited Scope

Up to the mid 1900’s, hundreds of thousands of acres across the United States were repeatedly treated with lead-arsenate pesticides to prevent the decimation of orchards by codling moths. Metal…

Pore to core: Changes in osmotic conditions due to varying antecedent soil moisture conditions drive microbial community composition

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Vanessa Bailey

Recent research has shown that bacterial invasion by phage, detected via CRISPR inserts, increases with increasing osmotic stress. We seek access to EMSL computing resources to explore existing…

Computational Studies of Nanoparticle Formation and Bulk Properties for Biomineralization

Lead Institution

University of Alabama

Principal Investigator

David Dixon

Project type

Large-Scale EMSL Research

There is a critical need to develop an understanding of nanoparticle and mineral formation in systems that contain H2O, metal ions and CO2 as carbonation and hydrolysis reactions are important for…

Atomic Resolution of the Structure and Fungal Degradation of Wood Secondary Cell Walls

Lead Institution

Michigan State University

Principal Investigator

Tuo Wang

Project type

Large-Scale EMSL Research

The proposed research aims at obtaining atomic-level information to construct four structural models that reflect the supramolecular architecture of plant secondary cell walls in hardwoods and…

Single-particle cryo-EM structural analysis of Q-dependent transcription antitermination

Lead Institution

Rutgers University

Principal Investigator

Richard Ebright

The transcription antitermination factor Q, produced by lambdoid bacteriophages, is a textbook example of a regulator of gene expression that functions at the level of transcription termination. Q…

Cell envelope characterization of members of the phylum Chlorobi

Lead Institution

University of British Columbia

Principal Investigator

Elitza Tocheva

Modern bacteria can be divided into two main groups based on their cell envelope architecture: monoderm and diderm. Typically, monoderm bacteria are surrounded by a single lipid bilayer and a thick…

Aerosol-Ice Formation Closure Study Applying Ambient Aerosol Particles

Lead Institution

State University of New York at Stony Brook

Principal Investigator

Daniel Knopf

Project type

Large-Scale EMSL Research

Atmospheric ice nucleation represents one of the least understood atmospheric processes, hampering prediction of cloud processes and climate. Whereas the aerosol community has widely conducted…

Structural characterization of nodule-specific cysteine-rich antifungal peptides and their phospholipid receptors for elucidation of their modes of action

Lead Institution

Donald Danforth Plant Science Center

Principal Investigator

Dilip Shah

Project type

Large-Scale EMSL Research

Antimicrobial peptides (AMPs) are a major component of innate immunity against infectious diseases in animals and plants [2]. A feature prominent in many families of AMPs, such as defensins (Figure 1…

Coupling Measurements and Modeling to Understand the Lifecycle of Secondary Organic Aerosol over Local to Regional Scales

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Jerome Fast

Project type

Large-Scale EMSL Research

Our hypothesis is that a better understanding of fast-reacting processes, such as the chemistry of volatile organic compounds associated with isoprene having a lifetime of ~minutes, is needed to make…

Elucidating unifying principles of soil C-N coupling using a continental scale grassland experimental network

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Kirsten Hofmockel

EMSL capabilities will be utilized for analysis of samples acquired from a continental-scale network of replicated, long-term grassland nutrient addition experiments, the Nutrient Network, to enhance…

Advancement of the molecular microscope to enable high-resolution dynamic imaging and unprecedented spatial metabolomic information of living systems

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Christopher Anderton

The ability to capture and visualize the complex metabolic behavior of living organisms in situ is a bioanalytical grand challenge that has yet to be fully realized. Ambient ionization mass…

Consortium for Advanced Sorghum Phenomics (CASP)

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Christer Jansson

The mission of the proposed project is to accelerate breeding of biomass sorghum to maximize terminal compositional (e.g., lignocellulosic) yield under drought and saline field conditions using novel…

EPICON: Epigenetic Control of Drought Acclimation in Sorghum

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Christer Jansson

Genetic manipulation of crops to increase the presence or intensity of desirable traits has been critical to increasing agricultural productivity. These changes have primarily involved modification…

Molecular Phenotyping of Plants & Microbes (MolPheno) for the PRedicting Ecosystem Resilience through Multiscale and Integrative Science (PREMIS) initiative

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Kim Hixson

This proposal aims to provide the fundamental molecular characterization necessary to develop a model which ultimately links phenotypic measurements to the soil biogeochemistry associated with…

Metabolic regulation of O-GlcNAc and cardiac function during hypertrophy

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Ljiljana Pasa-Tolic

Despite treatment advances, half of patients suffering from heart failure die within five years of diagnosis, while those who survive may live with severe disabilities. Cardiac hypertrophy poses a…

Understanding ATP synthase regulation

Lead Institution

The Victor Chang Cardiac Research Institute

Principal Investigator

Alastair Stewart

We aim to solve the cryo-EM structure of E. coli ATP synthase in its active form to high resolution utilising the PNCC Titan Krios equipped with a K2 camera. This research will be an extension of our…

Developing predictive understanding of subsurface flow and reactive geochemical transport through the use of Akuna: An Open Source and High-performance Workflow System for Subsurface Simulation

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Vicky Freedman

The primary objective of this project is to deploy and demonstrate how the Akuna software can be used to facilitate efficient modeling and analyses to address costs and benefits of engineering and…

Use of In Situ NMR and EPR to observe and identify active species in peracetic acid-catalyzed lignin oxidation

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Mariefel Olarte

This proposal aims to identify the active species from peracetic acid that are involved in the oxidative depolymerization of lignin. Results from this study will inform other efforts to identify…

Small-pore zeolite supported Cu/Fe as selective catalytic reduction catalysts, and Pd/Pt as passive NOx adsorbers and low-temperature methane combustion catalysts

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Feng Gao

To help meet DOE goals of enabling more fuel-efficient vehicle engine technologies, for the past ~15 years we have been carrying out research programs funded by DOE/Office of Energy Efficiency and…

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