Projects

Design of plasmonic probe tips to control light on the nanoscale for imaging and spectroscopy with ultrahigh spatial and temporal resolution

Lead Institution

University of Colorado at Boulder

Principal Investigator

Bernd Raschke

Project type

Large-Scale EMSL Research

The optical probing of matter with simultaneous nanometer spatial and femtosecond temporal resolution has remained a great challenge. Here, using focused ion beam milling we will tune the optical…

Reverse Methanogenesis: Validating the Hypothesis with Lineage-Resolved Environmental Proteomics

Lead Institution

University of British Columbia

Principal Investigator

Steven Hallam

Project type

Large-Scale EMSL Research

In marine sediments three known lineages of anaerobic methane oxidizing archaea (ANME-1, 2 and 3) filter up to ~384 Tg of the greenhouse gas methane annually, greatly reducing methane flux from ocean…

Dynamics of Bacterial Phosphoglucomutase via NMR Relaxation

Lead Institution

University of Missouri - Columbia

Principal Investigator

Steven Van Doren

Project type

Large-Scale EMSL Research

A bacterial enzyme known as phosphomannomutase / phosphoglucomutase (PMM/PGM) is required in the biosynthesis of the sugar capsule. Bacteria use this coating of complex carbohydrates in forming their…

Tying Distinct Nanoparticle Properties to Cell Surface Interactions and Intracellular Fate

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Joel Pounds

Project type

Large-Scale EMSL Research

The increasing use of engineered nanomaterials in industrial and medical applications is expected to increase both unintended environmental or occupational exposures and intended medical or direct…

Abiotic Reduction of U(VI) by Sorbed Fe(II) and the Implications for Field-Scale Bioremediation at the Rifle IFRC Project Site

Lead Institution

Lawrence Berkeley National Laboratory

Principal Investigator

Patricia Fox

Project type

Large-Scale EMSL Research

Uranium (U) contamination of aquifers is a problem at a number of DOE sites, and bioremediation is currently being investigated at the Integrated Field Research Challenge Site at Rifle, CO as a…

Interfacial and Multiphase Chemistry of Metal-Containing Atmospheric Dust Particles

Lead Institution

University of Iowa

Principal Investigator

Vicki Grassian

Project type

Large-Scale EMSL Research

This proposal is to use EMSL capabilities to perform laboratory studies to better understand how the properties of metal-containing atmospheric particles change as they undergo atmospheric transport…

Investigation of anaerobic lignocellulose decomposition in Puerto Rico tropical forest soils

Lead Institution

University of Massachusetts Amherst

Principal Investigator

Kristen DeAngelis

Project type

Large-Scale EMSL Research

As one of the primary objectives of the DOE Joint BioEnergy Institute (JBEI), our project aims to identify and characterize unique microorganisms, enzymes and pathways with novel lignocellulolytic…

Transformation Mechanisms and Kinetics of Fe-(oxyhydr)oxide Reduction and their Impact on Uranium Sequestration

Lead Institution

Stanford Linear Accelerator Center

Principal Investigator

Juan Lezama Pacheco

Project type

Large-Scale EMSL Research

Redox cycling of Fe-(oxyhydr)oxides such as ferrihydrite in naturally or artificially reduced sediments has a major impact on the speciation and stability of uranium. Ferrihydrite is a poorly…

Geobiology of Chemical Weathering: Spatially Explicit Characterization of the Inorganic Chemical Composition of Mycorrhizospheric Biofilms

Lead Institution

Washington State University

Principal Investigator

Chester Keller

Project type

Large-Scale EMSL Research

Rich literatures and recent advances across several fields have set the stage for process-based research into the biogeochemical agency of vascular plants -- in particular, how their physiologies…

The Quaternary Structures of Enamel Proteins at Interfaces Studied by Helium-ion Microscopy (HIM)

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Barbara Tarasevich

Project type

Large-Scale EMSL Research

The interactions of proteins at surfaces are of great importance to biomineralizaton processes and to the development and function of biomaterials. Amelogenin is a unique biomineralization protein…

Cell Injury Involving Transmetallation of Gadolinium Based MRI Contrast Agents

Lead Institution

Oregon Health & Science University

Principal Investigator

Wassana Yantasee

Project type

Large-Scale EMSL Research

This EMSL user proposal is directly responsive to Biological Interactions and Dynamics Science Theme. The work involves the fundamental studies on the heterogeneity in cell composition and response…

Ubiquitin Signaling and Bacterial Effector Proteins

Lead Institution

University of Washington

Principal Investigator

Peter Brzovic

Project type

Large-Scale EMSL Research

In plants and animals post-translational modification of proteins by ubiquitin (Ub) is a regulatory process that impacts nearly every aspect of eukaryotic cell biology. Diverse pathways including,…

Fundamental Studies of the Interaction of Pd and Rh Particles with Ceria and Ceria-Zirconia Surfaces in Model Planar atalysts

Lead Institution

University of Michigan

Principal Investigator

Xiaoqing Pan

Project type

Large-Scale EMSL Research

Ceria and ceria-based oxides have been widely investigated as electronic promoters of activity, selectivity, and thermal stability in a variety of catalysts. Pd on ceria-based supports is an…

Molecular Interactions and Dynamics at Solid Electrolyte Interfaces

Lead Institution

State University of New York at Binghamton

Principal Investigator

Howard Wang

Project type

Large-Scale EMSL Research

We will carry out a systematic study on molecular interactions and dynamics at solid electrolyte interfaces (SEIs) of Li-ion batteries using primarily in situ quantitative nonlinear optical…

Molecular-level Investigation of Dissolved and Stabilized Organic Carbon in Soil

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

James Amonette

Project type

Large-Scale EMSL Research

Soils contain large amounts of organic carbon (OC) and serve as both sources and sinks for atmospheric C. However, little is known about the structural chemistry of stabilized soil OC or the…

Biomineralization and Biosequestration Mechanisms at Lifes Upper Temperatures: A Reappraisal using Novel CryoEM Techniques

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Sherry Cady

Project type

Large-Scale EMSL Research

Given that (i) hyperthermophilic and thermophilic biofilms were some of the earliest microbial communities to inhabit our planet, (ii) such communities evolved and thrived in heavy metal-rich…

Looking for Partners in Crime: Identification of Protein Complexes and Post-Translational Modifications Associated with Drug-Resistance in Breast Cancer

Lead Institution

Erasmus University Medical Center, Rotterdam

Principal Investigator

Arzu Umar

Project type

Large-Scale EMSL Research

Drug resistance of metastatic tumor cells is the major cause of death in breast cancer patients. Through a previous EMSL collaboration, EMMPRIN (extracellular matrix metalloproteinase inducer) was…

Phosphoproteomics of Nuclear Pore Disassembly and Reassembly during Mitosis

Lead Institution

The Ohio State University

Principal Investigator

Stephen Osmani

Project type

Large-Scale EMSL Research

Eukaryotic cells segregate DNA equally to daughter cells during mitosis. Although mitosis is well characterized, its regulation is still poorly understood. The most extensive and least understood…

Transcriptional and epigenetic regulation following ionizing radiation exposure in a skin model system

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

David Stenoien

Project type

Exploratory Research

Dynamic post-translational modifications (PTMs) occurring on histones play essential roles in regulating transcription of specific target genes and in the epigenetic reprogramming occurring during…

Modeling Conduction in Organic Solar Cells

Lead Institution

University of California, Los Angeles

Principal Investigator

Daniel Neuhauser

Project type

Exploratory Research

We propose to model conduction in organic solar cells. Organic solar cells have promise in the manufacturing of efficient, inexpensive solar devices, which are essential to our energy future. A…