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Garry Buchko

Institution
Pacific Northwest National Laboratory
ORCID
ORCID logo 0000-0002-3639-1061

Projects

Structural Genomics Center for Infectious Diseases - Year III

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Garry Buchko
Project type
Exploratory Research
New medicines are urgently needed against infectious diseases that are becoming increasingly more resistant to current therapies. The strategy being used by the National Institute of Health (NIH) to…

Bio-Inspired Homogeneous Catalysts for Energy Storage and Production

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Molly O'Hagan
Project type
Large-Scale EMSL Research
This proposal is in response to the Energy Materials and Processes Science Theme proposal call requesting resources to support three research programs at PNNL: the DOE Basic Energy Sciences &quot…

Structural Proteomics of Myobacterium Tuberculosis

Lead Institution
Los Alamos National Laboratory
Principal Investigator
Thomas Terwilliger
Project type
Capability Research
Project Description: Due to the availability of the complete genome of M. tuberculosis and also in part to our development of a genetic system for studying gene function in M. tuberculosis, our…

Enamel biomineralization: Solution- and solid-state NMR

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Garry Buchko
Project type
Exploratory Research
Dental enamel, the layer of elongated carbonated hydroxyapatite on the outer layer of the tooth, is the hardest tissue in the human body. It needs to be strong because it cannot repair itself nor can…

Understanding proton movement in [FeFe]-hydrogenase

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joseph Laureanti
This proposed work ultimately aims to elucidate enzymatic design principles for proton transfer. We will employ the smallest and most NMR “friendly” version of this highly studied and well-known…

Structural Studies of Riboswitches

Lead Institution
Miami University
Principal Investigator
Michael Kennedy
Project type
Capability Research
Riboswitches are metabolite-binding domains in certain messenger RNAs that modulate gene expression in response to changing concentrations of metabolites. Riboswitches are composed of two functional…

Nanoparticles-Based Biosensors for Detection of Environmental Biomarkers

Lead Institution
Washington State University
Principal Investigator
Yuehe Lin
Project type
Large-Scale EMSL Research
Human exposure to toxic chemical agents (i.e. pesticides, nerve agents) and infectious agents, such as pathogens, may have some immune response, which is composed of both cellular and acellular…

A Systems Biology Approach to Infectious Diseases Research

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joshua Adkins
Project type
Exploratory Research
We describe an integrated program for coupling advanced capabilities in high-throughput transcriptomics, proteomics, and metabolomics with a comprehensive informatics infrastructure and a…

NMR Structural Studies of Clustered DNA Damage

Lead Institution
Miami University
Principal Investigator
Michael Kennedy
Project type
Capability Research
The primary objective of this research is to characterize the qualitative and quantitative similarities and differences in repair characteristics between clustered damage sites formed by ionizing…

Purity Analysis of Synthetic Organic Compounds

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Garry Buchko
Project type
Exploratory Research
NMR spectrometer time is requested for Dr. Garry W. Buchko (EMSL) to analyze occasional organic samples for Drs. Scott Harvey and Bob Wright. These latter NSD staff (PNNL) are both analytical…

Bioinspired Electrocatalysts for Energy Storage and Production Reactions.

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Wendy Shaw
Project type
Exploratory Research
Electrocatalysts can convert electrical energy into chemical bonds in fuels, such as H2. In the reverse reaction, electrocatalysts can use the fuel to generate electrical energy on demand. This…

Structural Genomics Collaborative Access Team (CAT)

Lead Institution
Miami University
Principal Investigator
Michael Kennedy
The Structural Genomics CAT will carry out research focused in structural genomics and related research areas with a primary goal of increasing throughput, maximizing efficiency of existing resources…

Protein Structure and Surface Interactions of an Enamel Protein

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Wendy Shaw
Project type
Capability Research
The structure and protein-surface interaction of an enamel protein, amelogenin, will be investigated both on and off of hydroxyapatite using solid state NMR. The formation of nanospheres (protein…

Seattle Structural Genomics Center for Infectious Diseases – Year XI

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Garry Buchko
A potential consequence of rapid climate change is the emergence of epidemic infectious zoonotic diseases as the habitats of disease carriers change to expose human populations to new infectious…