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Garry Buchko

Institution
Pacific Northwest National Laboratory
ORCID
ORCID logo 0000-0002-3639-1061

Projects

Structural Proteomics of Myobacterium Tuberculosis

Lead Institution
Los Alamos National Laboratory
Principal Investigator
Thomas Terwilliger
Project type
Capability Research
Project Description: Due to the availability of the complete genome of M. tuberculosis and also in part to our development of a genetic system for studying gene function in M. tuberculosis, our…

SSGCID Year IX

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Garry Buchko
As witnessed by the recent outbreak of Ebola in Africa, developing new drugs to combat emerging and re-emerging infectious diseases is of upmost importance. The National Institute of Allergy and…

Understanding proton movement in [FeFe]-hydrogenase

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joseph Laureanti
This proposed work ultimately aims to understand enzymatic design principles using a highly studied and well-known system by creating a series of mutant metalloenzymes to probe the validity and…

Structural Proteomics of Myobacterium Tuberculosis

Lead Institution
Los Alamos National Laboratory
Principal Investigator
Thomas Terwilliger
Project type
Capability Research
Project Description: Due to the availability of the complete genome of M. tuberculosis and also in part to our development of a genetic system for studying gene function in M. tuberculosis, our…

Structural Genomics Center for Infectious Diseases - Year III

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Garry Buchko
Project type
Exploratory Research
New medicines are urgently needed against infectious diseases that are becoming increasingly more resistant to current therapies. The strategy being used by the National Institute of Health (NIH) to…

Bio-Inspired Homogeneous Catalysts for Energy Storage and Production

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Molly O'Hagan
Project type
Large-Scale EMSL Research
This proposal is in response to the Energy Materials and Processes Science Theme proposal call requesting resources to support three research programs at PNNL: the DOE Basic Energy Sciences &quot…

Structural Proteomics of Myobacterium Tuberculosis

Lead Institution
Los Alamos National Laboratory
Principal Investigator
Thomas Terwilliger
Project type
Capability Research
Project Description: Due to the availability of the complete genome of M. tuberculosis and also in part to our development of a genetic system for studying gene function in M. tuberculosis, our…

Enamel biomineralization: Solution- and solid-state NMR

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Garry Buchko
Project type
Exploratory Research
Dental enamel, the layer of elongated carbonated hydroxyapatite on the outer layer of the tooth, is the hardest tissue in the human body. It needs to be strong because it cannot repair itself nor can…

Understanding proton movement in [FeFe]-hydrogenase

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joseph Laureanti
This proposed work ultimately aims to elucidate enzymatic design principles for proton transfer. We will employ the smallest and most NMR “friendly” version of this highly studied and well-known…

Structural Studies of Riboswitches

Lead Institution
Miami University
Principal Investigator
Michael Kennedy
Project type
Capability Research
Riboswitches are metabolite-binding domains in certain messenger RNAs that modulate gene expression in response to changing concentrations of metabolites. Riboswitches are composed of two functional…

Nanoparticles-Based Biosensors for Detection of Environmental Biomarkers

Lead Institution
Washington State University
Principal Investigator
Yuehe Lin
Project type
Large-Scale EMSL Research
Human exposure to toxic chemical agents (i.e. pesticides, nerve agents) and infectious agents, such as pathogens, may have some immune response, which is composed of both cellular and acellular…

A Systems Biology Approach to Infectious Diseases Research

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joshua Adkins
Project type
Exploratory Research
We describe an integrated program for coupling advanced capabilities in high-throughput transcriptomics, proteomics, and metabolomics with a comprehensive informatics infrastructure and a…