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Xuefeng Ren

Institution
Wayne State University

Projects

NMR Studies of Human Apolipoprotein-AI

Lead Institution
Wayne State University
Principal Investigator
Jianjun Wang
Project type
Capability Research
In this proposal, we plan to focus on determination of the NMR structure of lipid-free human apoA-I(1-186) and apoAI(1-209). ApoA-I is a 243-residue protein (28.1 kDa), which is the main protein…

NMR Studies of Human Apolipoprotein-E N-terminal Domain

Lead Institution
Wayne State University
Principal Investigator
Jianjun Wang
Project type
Capability Research
This research proposal is centered on NMR structural studies of human apolipoprotein-E (apoE). ApoE plays important roles in several human diseases, including atherosclerosis and Alzheimer’s diseases…

Structural Determination of Apolipoprotein/HDL Particles

Lead Institution
Wayne State University
Principal Investigator
Jianjun Wang
Project type
Capability Research
This research proposal is focused on determining the NMR structure of an exchangeable apolipoprotein, apolipophorin-III, that is associated with high-density lipoprotein (HDL). This is an important,…

Structural Studies of Lipid-free Apolipoprotein A-I

Lead Institution
Wayne State University
Principal Investigator
Jianjun Wang
Project type
Capability Research
Cholesterol is a lipid that is necessary for our body. Only the cholesterol that is in excess in the peripheral cells and blood vessels are the bad cholesterol and need to be transport by the HDL…

Structural Determination of Apolipoprotein A-I/preb-HDL Particles

Lead Institution
Wayne State University
Principal Investigator
Jianjun Wang
Project type
Capability Research
Apolipoprotein A-I (apoAI) is a 243-residue exchangeable apolipoprotein that plays a key role in the high-density lipoprotein (HDL) pathway, which clears the "bad cholesterol" from human…