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Identify Biomarkers for COPD (Chronic Obstructive Pulmonary Disease) in Humans using Metabonomic Analysis of Serum and Urine by NMR.


EMSL Project ID
16300

Abstract

Chronic Obstructive Pulmonary Disease (COPD) is a slowly progressive disease of the airways that is characterized by a gradual loss of lung function. COPD is a major cause of death and illness throughout the world, and is the fourth leading cause of death in the United States. The objective of this study is to identify putative biomarkers that may be predictive for, or correlate with, progression of COPD. Ultimately, and after extensive validation, the biomarkers may be useful for diagnosis and the determination of molecular targets and pathways. To accomplish this objective, 40 de-identified blood plasma samples from COPD patients at differing stages of COPD will be provided by the University of Utah through LineaGen Research Corporation (formerly GenData). NMR spectra of these samples will be used to determine the metabolites present at differing stages of COPD. Additionally, we will analyze a small number of samples by ‘gel-free’ 2-D capillary liquid chromatography (LC)-MS/MS to extend the human plasma PMT database to include peptides from subjects with COPD.

Project Details

Project type
Capability Research
Start Date
2005-10-01
End Date
2006-04-04
Status
Closed

Team

Principal Investigator

Joel Pounds
Institution
Pacific Northwest National Laboratory

Team Members

Joseph Ford
Institution
Pacific Northwest National Laboratory

Nancy Isern
Institution
Environmental Molecular Sciences Laboratory