MRI of chronic obstructive pulmonary disease
EMSL Project ID
25693
Abstract
Proposed work will be performed using normal rats and emphysematous counterparts. The specific aims are to - 1) quantify regional alveolar airway destruction in vivo using 19F gas MRI techniques appropriate for future clinical studies, and 2) validate MRI measurements via histological analysis of excised rat lungs
Project Details
Project type
Large-Scale EMSL Research
Start Date
2007-05-23
End Date
2009-09-30
Status
Closed
Released Data Link
Team
Principal Investigator
Team Members
Related Publications
Jacob RE, KR Minard, GJ Laicher, and C Timchalk. 2008. "3D 3He diffusion MRI as a local in vivo morphometric tool to evaluate emphysematous rat lungs." Journal of Applied Physiology 105:1291-1300.
R.E. Jacob et al., 3D MRI of non-Gaussian 3He gas diffusion in the rat lung, J. Magn. Reson. (2007), doi:10.1016/j.jmr.2007.08.014