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Richard Jacob

Institution
Pacific Northwest National Laboratory

Projects

Magnetic Resonance Microscopy of Environmental Lung Injury

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Kevin Minard
Project type
Capability Research
The goal for this project is to develop a three-dimensional (3D), geometric database that describes the remodeling of respiratory airways in Rhesus monkeys following ozone challenge. To accomplish…

MR Imaging of Respiratory Stucture and Function

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Kevin Minard
Project type
Capability Research
MR imaging methods are being developed to visualize pulmonary mechanics, define airway architecture, and measure the flow velocity of inhaled gases in live rats. Results provide a basis for…

Virtual Lung Validation Using Hyperpolarized 3He MRI

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Richard Jacob
Project type
Capability Research
The purpose of the present proposal is to develop magnetic resonance imaging (MRI) using hyperpolarized (HP) 3He gas for characterization of the flow of respired gas in the sinuses, trachea, and…

Magnetic Resonance Microscopy of Ozone-Induced Lung Injury

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Kevin Minard
Project type
Large-Scale EMSL Research
The goal for this project is to develop a three-dimensional (3D), geometric database that describes the remodeling of respiratory airways in Rhesus monkeys following ozone challenge.

Imaging Respiratory Structure and Function In Laboratory Animals

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Kevin Minard
Project type
Large-Scale EMSL Research
The goal for this NIH-funded project is to develop Magnetic Resonance (MR) imaging for visualizing - 1) airway architecture, 2) lung mechanics, 3) gas flow, and 4) particulate deposition in live…

MRI of chronic obstructive pulmonary disease

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Kevin Minard
Project type
Large-Scale EMSL Research
Proposed work will be performed using normal rats and emphysematous counterparts. The specific aims are to - 1) quantify regional alveolar airway destruction in vivo using 19F gas MRI techniques…

In-Vivo 1H NMR Spectroscopy of Pesticide Induced Neurotoxicity

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Charles Timchalk
Project type
Limited Scope
The developing brain is uniquely vulnerable to xenobiotic exposures at levels that do not appear to adversely impact adult brain function. In children, learning disabilities, neurological…

Physiologically-Based Biokinetic Model for Bacillus anthracis

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Richard Jacob
Project type
Limited Scope
The objective of this work is to develop a preliminary predictive model for inhalational anthrax through the use of published literature as well as in vivo and in vitro data that have been, and will…