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Virtual Lung Validation Using Hyperpolarized 3He MRI


EMSL Project ID
2408

Abstract

The purpose of the present proposal is to develop magnetic resonance imaging (MRI) using hyperpolarized (HP) 3He gas for characterization of the flow of respired gas in the sinuses, trachea, and bronchial airways. This characterization is a critical component in the Virtual Lung project, a computational model of the mammalian respiratory tract being developed at PNNL. This model will ultimately be used to predict the response of the lung to developing disease or to insult, resulting in a better understanding of health risks associated with the inhalation of particulate matter. The reliability of the model depends crucially on its validation, which will be accomplished by quantitative imaging of the gas flow, first in plastic flow phantoms of the respiratory tract and eventually in live animals. Preliminary studies of the feasibility of the model validation will be conducted during the collaborative visit. Our principal contact and collaborate will be Kevin Minard of the EMSL.

Project Details

Project type
Capability Research
Start Date
2002-03-13
End Date
2002-09-03
Status
Closed

Team

Principal Investigator

Richard Jacob
Institution
Pacific Northwest National Laboratory

Team Members

Gernot Laicher
Institution
University of Utah

Brian Saam
Institution
University of Utah

Related Publications

Einstein DR, B Neradilak, N Pollisar, KR Minard, C Wallis, M Fanucchi, JP Carson, AP Kuprat, S Kabilan, R Jacob, and R Corley. 2008. "An Automated Self-similarity Analysis of the Pulmonary Tree of the Sprague-Dawley Rat." The Anatomical Record 291(12):1628-1648. doi:10.1002/ar.20771