Skip to main content

Imaging Respiratory Structure and Function In Laboratory Animals

EMSL Project ID



The goal for this NIH-funded project is to develop Magnetic Resonance (MR) imaging for visualizing - 1) airway architecture, 2) lung mechanics, 3) gas flow, and 4) particulate deposition in live rodents.

Project Details

Project type
Large-Scale EMSL Research
Start Date
End Date


Principal Investigator

Kevin Minard
Pacific Northwest National Laboratory

Team Members

Richard Corley
Pacific Northwest National Laboratory

Richard Jacob
Pacific Northwest National Laboratory

Charles Timchalk
Pacific Northwest National Laboratory

Related Publications

Corley RA, S Kabilan, AP Kuprat, JP Carson, KR Minard, RE Jacob, C Timchalk, RW Glenny, S Pipavath, TC Cox, C Wallis, R Larson, M Fanucchi, E Postlewait, and DR Einstein. 2012. "COMPARATIVE COMPUTATIONAL MODELING OF AIRFLOWS AND VAPOR DOSIMETY IN THE RESPIRATORY TRACTS OF RAT, MONKEY, AND HUMAN." Toxicological Sciences 128(2):500-516. doi:10.1093/toxsci/kfs168
Einstein DR, B Neradilak, N Pollisar, KR Minard, C Wallis, M Fanucchi, JP Carson, AP Kuprat, S Kabilan, R Jacob, and R Corley. 2008. "An Automated Self-similarity Analysis of the Pulmonary Tree of the Sprague-Dawley Rat." The Anatomical Record 291(12):1628-1648. doi:10.1002/ar.20771
Ferguson MR, KR Minard, and KM Krishnan. 2009. "Optimization of nanoparticle core size for magnetic particle imaging." Journal of Magnetism and Magnetic Materials. 321(10):1548-1551 (2009).
Jacob RE, KR Minard, GJ Laicher, and C Timchalk. 2008. "3D 3He diffusion MRI as a local in vivo morphometric tool to evaluate emphysematous rat lungs." Journal of Applied Physiology 105:1291-1300.
K.R. Minard, D.R. Einstein, R.E. Jacob, S. Kabilan, A. Kuprat, C. Timchalk, L. Trease, and R.A. Corley, Application of Magnetic Resonance (MR) Imaging for the Development and Validation of Computational Fluid Dynamic (CFD) Models of the Rat Respiratory System, Inhalation Toxicology, 18: 787–794 (2006).
Minard KR, AP Kuprat, S Kabilan, RE Jacob, DR Einstein, JP Carson, and RA Corley. 2012. "Phase-Contrast MRI and CFD Modeling of Apparent 3He Gas Flow in Rat Pulmonary Airways." Journal of Magnetic Resonance 221:129-138. doi:10.1016/j.jmr.2012.05.007
Minard KR, RE Jacob, G Laicher, DR Einstein, AP Kuprat, and RA Corley. 2008. "MR Imaging of Apparent 3He Gas Transport in Narrow Pipes and Rodent Airways ." Journal of Magnetic Resonance 194(2):182-191. doi:10.1016/j.jmr.2008.07.006
R.E. Jacob, B.G. Amidan, J. Soelberg. K.R. Minard. "In Vivo MRI of Altered Proton Signal Intensity and T2 Relaxation in a Bleomycin Model of Pulmonary Inflammation and Fibrosis," J Magn Reson Imaging, 31:1091?1099 (2010).
S.A. Carey, K.R. Minard, J.S. Kimbell, L.L. Trease, C.G. Plopper, R.A. Corley, E.M. Postlethwait, and J.R. Harkema, Three-Dimensional Mapping of Ozone-Induced Lesions in the Nasal Airways of Monkeys Using Magnetic Resonance Imaging and Morphometric Techniques, Toxicologic Pathology, 35(1): 27-40 (2007).