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Ultra-High Resolution Ion Mobility-Mass Spectrometry Metabolomics Platform


EMSL Project ID
60260

Abstract

Metabolomics is increasingly utilized and essential to biomedical research and has broad potential applications extending to the clinic. This potential is inhibited by the limitations of current platforms that are largely based upon either the combination of chromatography separations with mass spectrometry (MS) or by MS alone. The objective of this project is to develop a new ultra-high resolution and ultra-sensitive platform that will enable much higher quality and more comprehensive metabolomics measurements than previously feasible and to do so with significant gains in measurement throughput. The key developments will involve the implementation of greatly improved ion mobility (IM) separations providing much greater speed, broader applicability to metabolite chemical classes, and also enabling improved sensitivity and measurement dynamic range to be achieved in conjunction with mass spectrometry (MS). The new IM-MS platform development efforts will include the essential platform control and data acquisition capabilities and result in a platform ready for initial metabolomics applications, as well as a foundation for its rapid dissemination.

Project Details

Start Date
2021-11-16
End Date
N/A
Status
Active

Team

Principal Investigator

Yehia Ibrahim
Institution
Pacific Northwest National Laboratory

Team Members

Adam Huntley
Institution
Pacific Northwest National Laboratory

Joon-Yong Lee
Institution
Pacific Northwest National Laboratory

Randolph Norheim
Institution
Environmental Molecular Sciences Laboratory

Christina Stevenson
Institution
Pacific Northwest National Laboratory