Christina Stevenson

CAT - A hybrid IMS-MS platform for ultrasensitive and high resolution glycan analysis

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Keqi Tang

The specific functions of glycans in a given biological process or pathogenic condition depend on their specific molecular compositions and structures. Accurate and quantitative measurements of…

EMERGING VIRUS-HOST CELL PROTEIN INTERACTION NETWORKS

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Ernesto Nakayasu

The overall goal of this proposal is to identify and characterize cellular proteins that bind to viral hemorrhagic fever viruses. Specifically, we focus on RNA viruses from four families: the…

Pan-Omics Technology Development, Implementation, and Application to GSP Systems Biology Research

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Joshua Adkins

The BER Genome Science Program aims to understand complex biological and environmental systems across spatial and temporal scales to develop predictive knowledge relevant to DOE mission challenges…

Collaborative research projects in the PNNL NIH P41 Biomedical Technology Research Center 'Proteomics research resource for integrative biology'

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Jon Jacobs

Collaborative research projects in the PNNL NIH P41 Biomedical Technology Research Center 'Proteomics research resource for integrative biology'

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Jon Jacobs

Collaborative research projects in the PNNL NIH P41 Biomedical Technology Research Center 'Proteomics research resource for integrative biology'

Ultra-High Resolution Ion Mobility-Mass Spectrometry Metabolomics Platform

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Yehia Ibrahim

Metabolomics is increasingly utilized and essential to biomedical research and has broad potential applications extending to the clinic. This potential is inhibited by the limitations of current…

The effect of monoclonal antibodies against HSP60 on Histoplasma capsulatum extracellular vesicles

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Ernesto Nakayasu

The capacity of the human fungal pathogen Histoplasma capsulatum (Hc) to cause severe invasive disease is attributed to the fungus’ ability to subvert host responses, especially in the setting of…

Developing a strategy to identify & validate pharmacodynamic kinase inhibitorbiomarkers

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Keqi Tang

The primary goal of the project is to develop mass spectrometry (MS) based assays capable of globally quantifying changes in kinase-specific phosphorylation stoichiometry. The specific work related…

Pan-Omics Technology Development, Implementation, and Application to GSP Systems Biology Research

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Joshua Adkins

The BER Genome Science Program aims to understand complex biological and environmental systems across spatial and temporal scales to develop predictive knowledge relevant to DOE mission challenges…

Statistical Methodology for Characterization of Macromolecular Similarity

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

John Cort

As with any drug, approval of generic versions of macromolecular drugs requires rigorous evaluation of therapeutic equivalence to the reference drug in order to assure similar efficacy and safety…

Discovery of Host Proteins Involved in Host-Pathogen Interactions

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Joshua Adkins

The multiple mechanisms by which pathogenic enterobacteria of the genus Salmonella infect their host indicate a complex host-pathogen relationship. The pathogen secretes dozens of proteins, termed &…

CAT - A hybrid IMS-MS platform for ultrasensitive and high resolution glycan analysis

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Keqi Tang

The specific functions of glycans in a given biological process or pathogenic condition depend on their specific molecular compositions and structures. Accurate and quantitative measurements of…

Massively Parallel Molecular Profiling of Breast Cancer

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Richard Smith

Molecular profiling of breast cancer into subcategories based on functional ER expression and amplification of HER2 has significantly enhanced our understanding of the disease, and has pointed the…

EMERGING VIRUS-HOST CELL PROTEIN INTERACTION NETWORKS

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Ernesto Nakayasu

The overall goal of this proposal is to identify and characterize cellular proteins that bind to viral hemorrhagic fever viruses. Specifically, we focus on RNA viruses from four families: the…

An ultrasensitive mass spectrometry platform for comprehensive analysis of lipids

Lead Institution

University of North Carolina Greensboro

Principal Investigator

Qibin Zhang

The specific functions of lipids are related to their chemical and physical properties and depend on specific molecular structures. Despite technological advancements that have made mass spectrometry…

The effect of monoclonal antibodies against HSP60 on Histoplasma capsulatum extracellular vesicles

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Ernesto Nakayasu

The capacity of the human fungal pathogen Histoplasma capsulatum (Hc) to cause severe invasive disease is attributed to the fungus’ ability to subvert host responses, especially in the setting of…

Collaborative research projects in the PNNL NIH NCRR P41 Biomedical Technology Research Center 'Proteomics research resource for integrative biology'

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Jon Jacobs

Collaborative research projects in the PNNL NIH NCRR P41 Biomedical Technology Research Center 'Proteomics research resource for integrative biology'

Statistical Methodology for Characterization of Macromolecular Similarity

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

John Cort

As with any drug, approval of generic versions of macromolecular drugs requires rigorous evaluation of therapeutic equivalence to the reference drug in order to assure similar efficacy and safety…

Modeling Host Responses to Understand Severe Human Virus Infections

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Richard Smith

This comprehensive and highly integrated systems biology program seeks to delineate the complex host responses that determine the outcome of infections with potentially lethal viruses. To achieve…

High Resolution High Throughput Proteomics Platform for Cancer Research

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Yehia Ibrahim

The objective of this project is to develop and evaluate a new high-throughput and ultra-sensitive platform that will enable more effective and higher throughput proteomics measurements to support…

Pan-Omics Technology Development, Implementation, and Application to GSP Systems Biology Research

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Joshua Adkins

The BER Genome Science Program aims to understand complex biological and environmental systems across spatial and temporal scales to develop predictive knowledge relevant to DOE mission challenges…

High Resolution High Throughput Proteomics Platform for Cancer Research

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Yehia Ibrahim

The objective of this project is to develop and evaluate a new high-throughput and ultra-sensitive platform that will enable more effective and higher throughput proteomics measurements to support…

Discovery of Host Proteins Involved in Host-Pathogen Interactions

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Joshua Adkins

The multiple mechanisms by which pathogenic enterobacteria of the genus Salmonella infect their host indicate a complex host-pathogen relationship. The pathogen secretes dozens of proteins, termed &…

Identification of Metabolite Toxins

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

David Wunschel

This project will collect data on ion-mobility, accurate mass and compound fragmentation data using an ESI-IMS-MS/MS system for a number of metabolite toxins and structurally similar compounds. This…

An ultrasensitive mass spectrometry platform for comprehensive analysis of lipids

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Keqi Tang

The specific functions of lipids are related to their chemical and physical properties and depend on specific molecular structures. Despite technological advancements that have made mass spectrometry…

The effect of monoclonal antibodies against HSP60 on Histoplasma capsulatum extracellular vesicles

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Ernesto Nakayasu

The capacity of the human fungal pathogen Histoplasma capsulatum (Hc) to cause severe invasive disease is attributed to the fungus’ ability to subvert host responses, especially in the setting of…

Regulatory Networks and Biomarkers of Beta-cell Dysfunction and Apoptosis

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Weijun Qian

In type 1 diabetes (T1D) research there remains a critical need for having a systems level understanding of the early stage molecular mechanisms that trigger the specific destruction of pancreatic β…

Collaborative research projects in the PNNL NIH P41 Biomedical Technology Research Center 'Proteomics research resource for integrative biology'

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Jon Jacobs

Collaborative research projects in the PNNL NIH P41 Biomedical Technology Research Center 'Proteomics research resource for integrative biology'

Dissection and Deciphering of the Soil Microbiome

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Janet Jansson

This proposal aims to address key gaps in our knowledge about the composition and functional roles of the tens of thousands of microbial species in soil. Although these microorganisms carry out…

Ultra-High Resolution Ion Mobility-Mass Spectrometry Metabolomics Platform

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Yehia Ibrahim

Metabolomics is increasingly utilized and essential to biomedical research and has broad potential applications extending to the clinic. This potential is inhibited by the limitations of current…

Projects