Projects

Molecular-level Investigation of Dissolved and Stabilized Organic Carbon in Soil

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

James Amonette

Project type

Large-Scale EMSL Research

Soils contain large amounts of organic carbon (OC) and serve as both sources and sinks for atmospheric C. However, little is known about the structural chemistry of stabilized soil OC or the…

Biomineralization and Biosequestration Mechanisms at Lifes Upper Temperatures: A Reappraisal using Novel CryoEM Techniques

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Sherry Cady

Project type

Large-Scale EMSL Research

Given that (i) hyperthermophilic and thermophilic biofilms were some of the earliest microbial communities to inhabit our planet, (ii) such communities evolved and thrived in heavy metal-rich…

Looking for Partners in Crime: Identification of Protein Complexes and Post-Translational Modifications Associated with Drug-Resistance in Breast Cancer

Lead Institution

Erasmus University Medical Center, Rotterdam

Principal Investigator

Arzu Umar

Project type

Large-Scale EMSL Research

Drug resistance of metastatic tumor cells is the major cause of death in breast cancer patients. Through a previous EMSL collaboration, EMMPRIN (extracellular matrix metalloproteinase inducer) was…

Phosphoproteomics of Nuclear Pore Disassembly and Reassembly during Mitosis

Lead Institution

The Ohio State University

Principal Investigator

Stephen Osmani

Project type

Large-Scale EMSL Research

Eukaryotic cells segregate DNA equally to daughter cells during mitosis. Although mitosis is well characterized, its regulation is still poorly understood. The most extensive and least understood…

Estimation of lifetime and evaluation of (Co,Mn)3O4 coatings for IT-SOFC Steel Interconnects application by determining of Cr and O diffusion coefficients

Lead Institution

Western Michigan University

Principal Investigator

Asghar Kayani

Project type

Large-Scale EMSL Research

Intermediate temperature solid oxide fuel (IT-SOFC) are becoming increasingly attractive as a way of producing energy from a variety of fuels such as hydrogen and hydrocarbons, which can be used for…

Structure and Reactivity of Ices, Amorphous Solids, and Supercooled Liquid Solutions at Interfaces and in the Condensed Phase

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

R. Smith

Project type

Large-Scale EMSL Research

The objective of this research is to examine physiochemical phenomena occurring at the surface and within the bulk of ices, amorphous solids, and supercooled liquid solutions. Our approach will be…

Extending Complementary-Metal-Oxide-Semiconductor Technology Into the Future

Lead Institution

Northwestern University

Principal Investigator

David Seidman

Project type

Large-Scale EMSL Research

With the continuous scaling of microelectronic device dimensions, the variability in MOSFET characteristics, primarily due to the discrete distribution of dopant atoms is a major challenge facing the…

Deciphering the 24 nt siRNA Biogenesis and Chromatin Modification Network in Plants

Lead Institution

Indiana University - Bloomington

Principal Investigator

Craig Pikaard

Project type

Large-Scale EMSL Research

Small RNAs, including short interfering RNAs (siRNAs) and micro RNAs (miRNAs) play essential roles in development, nuclear organization of the genome, transposon taming, and defense against viral and…

The ISO-BOSS: Quantifying and Resolving Metabolic Rates and Metabolic Pathways in the Deep Subsurface Biosphere

Lead Institution

Harvard University

Principal Investigator

Peter Girguis

Project type

Large-Scale EMSL Research

Title: The ISO-BOSS: Quantifying and resolving metabolic rates and metabolic pathways in the deep subsurface biosphere PNNL ISO-BOSS abstract Recent evidence has shown that an extensive…

Coupled Surface and Solid-State Charge and Ion Transport Dynamics at Mineral/Water Interfaces: Redox Transformation of the Iron Oxides

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Kevin Rosso

Project type

Large-Scale EMSL Research

This EMSL user proposal requests a continuation of EMSL access for a BES Geosciences supported project led by Dr. Rosso at PNNL. The past three years of research under this BES project we have been…

Activity-based Protein Capture of Archaeal Enzymes to Constrain Physiological Activity and Their Role in Global Methane Cycling

Lead Institution

Harvard University

Principal Investigator

Peter Girguis

Project type

Large-Scale EMSL Research

Methane is a potent greenhouse gas, capable of absorbing and releasing 25 times more heat to the atmosphere per molecule than carbon dioxide. A significant fraction of methane on Earth is…

Towards Complete Proteome Coverage and Identification of the Entire Protein Coding Potential of the Model Pathogen Bartonella henselae

Lead Institution

University of Zurich

Principal Investigator

Christian Ahrens

Project type

Large-Scale EMSL Research

Complete proteome discovery projects provide unique information not amenable by genomics technologies, including genes missed in the genome annotation, protein modifications, the true expression…

Experimental Capabilities and Fundamental Science for Geologic Carbon Sequestration: The PNNL In Situ Supercritical Suite (IS3)

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Kevin Rosso

Project type

Large-Scale EMSL Research

This Science Theme proposal requests EMSL access for investigators in the In Situ Supercritical Suite (IS3) component of PNNL's Carbon Sequestration Initiative (CSI). The CSI is a multi-million…

Laboratory and Field Studies of Cloud Formation

Lead Institution

Purdue University

Principal Investigator

Daniel Cziczo

Project type

Large-Scale EMSL Research

The relationship between aerosol particles and the formation of clouds is among the most uncertain aspects in our current understanding of climate change. Warm clouds have been the most extensively…

New Materials for Solar Cells Revealed via Quantum Mechanics

Lead Institution

Princeton University

Principal Investigator

Emily Carter

Project type

Large-Scale EMSL Research

This project is motivated by the low conversion efficiency of inexpensive solar cells intended as an alternative to fossil fuels, the primary energy resource. The research objectives are to explore…

Role of Protein Dynamics in G Protein Signaling

Lead Institution

University of Montana

Principal Investigator

Stephen Sprang

Project type

Large-Scale EMSL Research

This is a multi-investigator project aimed at understanding the role of protein dynamics in controlling the catalytic properties of an important family of biological regulators: the G-alpha subunits…

The Role of Interfacial Processes on Mineral Transformations in Wet Supercritical CO2

Lead Institution

Washington State University

Principal Investigator

Andrew Felmy

Project type

Large-Scale EMSL Research

We propose a comprehensive experimental and theoretical investigation of the role of interfacial water and CO2 on the energies, mechanisms, and rates of reactivity of a series of orthosilicate and…

Atomically Resolved Studies of Catalytic Oxidation of Organics on TiO2(110)

Lead Institution

Baylor University

Principal Investigator

Zhenrong Zhang

Project type

Large-Scale EMSL Research

A fundamental understanding of the structure-related mechanisms and dynamics of catalytic reactions on oxide catalysts is essential for the development of better catalytic systems. Catalytic…

Pore-Scale Evaluation of the Effect of Bioavailable Iron on U(Vi) Reduction Kinetics and U(Iv) Re-Oxidation of Relevance to Bioremediation Efforts at the Hanford Site

Lead Institution

University of Texas at Austin

Principal Investigator

Charles Werth

Project type

Large-Scale EMSL Research

Scores of hazardous waste sites are contaminated with uranium, primarily due to uranium mining and processing by the Department of Energy over a 40-year period between 1940 and 1980 (Wolbarst et al.,…

Probing the Fundamental Interactions in Carbon Capture and Sequestration: A Combined Computational and Experimental Investigation

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Vassiliki-Alexandra Glezakou

Project type

Large-Scale EMSL Research

The proposed work will investigate the fundamental interactions between sc-CO2 and metal/metal oxide or carbonate surfaces in the presence of other contaminants and metal impurities, in order to…