Projects

Cellular Interactions and Fate of Engineered Nanomaterials in Alveolar Epithelial Cells at the Air-Liquid Interface

Lead Institution

Oregon State University

Principal Investigator

Bettye Maddux

Project type

Large-Scale EMSL Research

The growing commerce in micro- and nanotechnology is expected to increase human exposure to submicrometer and nanoscale particles. Adverse effects of these particles on living systems have been…

Nanoparticle design, synthesis and characterization for NIH Center Integrating Structure, Activity, Biokinetics and Response for Engineered Nanoparticle (ENP) Risk Assessment

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Donald Baer

Project type

Large-Scale EMSL Research

This work provides the essential materials science base for designing, synthesizing and delivering three types of nanoparticles for three mechanistic nanotoxicology related biological studies being…

Chemical Imaging Analysis of Environmental Particles

Lead Institution

Purdue University

Principal Investigator

Alexander Laskin

Project type

Large-Scale EMSL Research

This project focuses on laboratory studies that investigate the relationship between particle morphology, composition, formation, reactivity, and evaporation by developing novel methods for chemical…

Cross-talk between DNA methylation and histone post-translational modifications in Arabidopsis

Lead Institution

Indiana University - Bloomington

Principal Investigator

Craig Pikaard

Project type

Large-Scale EMSL Research

In eukaryotes, chromosomal DNA must be highly compacted by proteins in order to fit within the confines of the nucleus, yet must also allow the DNA to be accessible for transcription, replication and…

Effects of Ion Irradiation on Metallic-Glasses and High-Entropy Alloys

Lead Institution

Oak Ridge National Laboratory

Principal Investigator

Yanwen Zhang

Project type

Large-Scale EMSL Research

Ion irradiation is possible to cause amorphization in crystalline materials, leading to mechanical performance degradation. Bulk metallic glasses (BMGs) have no such problems, because they are…

Solid-State NMR Structural and Dynamics Studies of HIV-1 Protein Assemblies

Lead Institution

University of Delaware

Principal Investigator

Tatyana Polenova

Project type

Large-Scale EMSL Research

This is an application in response to the proposal call "Science Theme: Biological Interactions and Dynamics". We request standard, general non-proprietary access to the 850 and 900 MHz…

Molecular Characterization of Secondary Organic Aerosol Formed via Aqueous-phase Reactions of Phenolic Compounds

Lead Institution

University of California, Davis

Principal Investigator

Qi Zhang

Project type

Large-Scale EMSL Research

The main objective of this proposed project is to perform detailed, molecular- level characterization of the chemical composition of secondary organic aerosol formed via aqueous-phase reactions of…

Molecular Chemistry of Nitrogen-Containing Light-Absorbing Compounds in Atmospheric Organic Aerosol

Lead Institution

Fudan University

Principal Investigator

Xin Yang

Project type

Large-Scale EMSL Research

Most atmospheric aerosols scatter visible radiation back to space and therefore reduce the amount of solar energy reaching the surface. However, certain types of aerosols absorb visible radiation and…

Developing efficient fungal biocatalysts for on-site enzyme production and for production of chemical building blocks in biorefineries using metabolomic and secretomic profiling

Lead Institution

Aalborg University

Principal Investigator

Mette Lubeck

Project type

Large-Scale EMSL Research

Development of biocatalysts for sustainable production of bioactive molecules from lignocellulosic plant biomass in biorefineries is a rapid growing research area. One of the most important and…

Preparation of Novel Catalytic Materials Using Soft- and Reactive Landing of Ions

Lead Institution

National Dong Hwa University

Principal Investigator

Wen-Ping Peng

Project type

Large-Scale EMSL Research

The proposed work is focused on obtaining a molecular-level understanding of the structure-reactivity relationships of catalytically active small metal clusters and organometallic molecules deposited…

Visualizing the Effects of Engineered Chimeric Growth Factors on Receptor Distribution

Lead Institution

Massachusetts Institute of Technology

Principal Investigator

Linda Griffith

Project type

Large-Scale EMSL Research

Members of the epidermal growth factor receptor (EGFR/HER/ErbB) family - EGFR, HER2, HER3, and HER4 - regulate diverse cell behaviors including survival, proliferation, differentiation and migration…

Large-scale computational modeling of the chemical transformation of actinide elements at interfaces

Lead Institution

Lawrence Berkeley National Laboratory

Principal Investigator

Wibe De Jong

Project type

Large-Scale EMSL Research

Subsurface migration of radioactive waste resulting from nuclear energy and weapons production is a critical issue to the U.S. Department of Energy (DOE), and the safe and cost-effective disposal of…

Cluster Model Studies of Condensed Phase Phenomena at Well-Defined Conditions

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Xuebin Wang

Project type

Large-Scale EMSL Research

This program is aimed at obtaining a microscopic understanding of solution chemistry and condensed phase phenomena using gas phase clusters as model systems.Our current focus is on the microsolvation…

Mass Spectrometry Imaging of Microbial Communities

Lead Institution

University of California, San Diego

Principal Investigator

Pieter Dorrestein

Project type

Large-Scale EMSL Research

Despite our significant technological advancements, the solutions to many of humanities lingering problems such as bioremediation of toxic heavy metal environmental contaminants, creation of…

Biogeochemical transformation of soil Fe- and Mn- mineral phases along a redox gradient: Implications for C sequestration

Lead Institution

University of Delaware

Principal Investigator

Donald Sparks

Project type

Large-Scale EMSL Research

Iron (Fe) and manganese (Mn) oxides, hydroxides and oxyhydroxides are well known redox-sensitive mineral components of environmental systems. Iron minerals in soils and sediments occur in a variety…

Reactivity of iron-bearing phyllosilicates with uranium and chromium through redox transitions zones

Lead Institution

Miami University

Principal Investigator

Hailiang Dong

Project type

Large-Scale EMSL Research

Iron-bearing phyllosilicate minerals are widely distributed and often account for about half of the iron in soils and sediments. They play an important role in environmental processes such as…

Enamel biomineralization: Solution- and solid-state NMR studies of a natural protein-mineral interfaces

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Garry Buchko

Project type

Large-Scale EMSL Research

Dental enamel, the 1-2 mm layer of elongated carbonated hydroxayapatite on the outer layer of the tooth, is the hardest tissue in the human body. It needs to be strong because it is exposed to…

Horizontal Gene Transfer in Porous Media: A Real Time Microscopic Investigation

Lead Institution

University of Illinois at Urbana-Champaign

Principal Investigator

Thanh Nguyen

Project type

Large-Scale EMSL Research

Horizontal gene transfer is widespread among bacteria and is an important component of microbial evolution and trait dispersal. Specifically, gene transfer can create new metabolic capabilities, e.g…

Excitation and Desorption of Nano-crystalline ZrO2

Lead Institution

University College London

Principal Investigator

Alexander Shlyuger

Project type

Large-Scale EMSL Research

This project is focused on integrated theoretical and experimental studies of the interaction of light with nanoscale oxide materials of fundamental interest to the fields of photo-catalysis,…

Characterization of the affects of specialized acyl carrier proteins on unusual LPS-hydroxy fatty acids in Geobacter metallireducens

Lead Institution

Miami University

Principal Investigator

Theresa Ramelot

Project type

Large-Scale EMSL Research

Many bacteria have specialized acyl carrier proteins (ACPs) that are involved in synthesis of diverse lipopolysaccharides (LPS). Diversity within LPS aids in survival of Gram-negative bacteria in…