Projects

Pathogen Control for a Sustainable Reuse of Wastewater: Role of Surface Interactions on Transport of Cryptosporidium parvum oocysts in Subsurface

Lead Institution

University of Illinois at Urbana-Champaign

Principal Investigator

Thanh Nguyen

Project type

Exploratory Research

Transport of pathogens such as Cryptosporidium parvum oocysts in subsurface environment is of great concern for water resources protection or drinking water treatment. Groundwater source for drinking…

Monitoring the Global Conformation of SRP During Co-translational Protein Targeting

Lead Institution

California Institute of Technology

Principal Investigator

Vinh Lam

Project type

Exploratory Research

The signal recognition particle (SRP) is the major cellular machinery that mediates co-translational targeting of membrane and secretory proteins to the eukaryotic endoplasmic reticulum (ER) membrane…

Structure-Function Relationships in Nanoscale Electrocatalysis

Lead Institution

University of Washington

Principal Investigator

Bo Zhang

Project type

Exploratory Research

The goal of this proposal is to investigate the relationship between electrocatalytic activity and geometric characteristics at single metal nanowires. A key aspect of the proposed research is that…

Nanoparticle Characterization for Systems Analysis of Biocompatibility

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Barbara Tarasevich

Project type

Exploratory Research

The goal of this research is to develop an understanding of how the physicochemical properties of nanomaterials influence their ability to interact with cells and stimulate biological responses. The…

Computational Study of Protein-Protein Interaction Dynamics at Single Molecule Level

Lead Institution

State University of New York at Stony Brook

Principal Investigator

Jin Wang

Project type

Exploratory Research

The dynamic process of binding occurs in a wide dynamic range, including millisecond to second timescale range. To be able to connect and compare computational simulation results with the results…

COMBINED EPR, NMR, MAGNETIC SUSCEPTIBILITY AND COMPUTATIONAL DETERMINATION OF RARE EARTH HYPERFINE EFFECTS IN CERAMICS.

Lead Institution

University of Cambridge

Principal Investigator

Ian Farnan

Project type

Exploratory Research

The first successful high-resolution solid-state NMR experiments on plutonium containing ceramics were carried out at EMSL. As these breakthrough experiments are exploited in the radiological NMR…

Xenoestrogen effect on trout histones

Lead Institution

University of Idaho

Principal Investigator

James Nagler

Project type

Exploratory Research

We are using a fish model, the rainbow trout, as a human surrogate to investigate the reproductive consequences of xenoestrogen exposure on male reproduction. Our previous studies have documented…

Interaction of nickel-based SOFC anode with trace species in coal derived synthesis gas

Lead Institution

National Energy Technology Laboratory

Principal Investigator

Kirk Gerdes

Project type

Exploratory Research

Solid oxide fuel cells (SOFC) utilizing nickel-based anodes have been widely studied at scales spanning micro (interfaces) to macro (system integration). In particular, SOFC have been investigated in…

Investigation into the Mechanism of Soot Formation from Biomass Combustion

Lead Institution

University of Leeds

Principal Investigator

Maria Romero

Project type

Exploratory Research

Biomass combustion is currently a significant energy source in developing countries and is likely to become more significant to developed countries due to the search for alternatives to fossil fuel…

Quantum Mechanical and Molecular Mechanical Methods for Iron-Sulfur Proteins

Lead Institution

Texas A&M University

Principal Investigator

Shuqiang Niu

Project type

Exploratory Research

Iron-sulfur proteins are essential in bioenergetics, including respiration, photosynthesis, nitrogen fixation, and hydrogen production and thus are prime candidates for bioengineering or biomimetic…

Measuring nanometer distances in the packaging RNA using Double Electron-Electron Resonance.

Lead Institution

University of Southern California

Principal Investigator

Peter Qin

Project type

Exploratory Research

In this renewal application we request to continue to use the pulsed EPR spectrometer at EMSL. We will use the instrument to measure nanometer distances in a complex of the packaging RNA (pRNA),…

XPS Analysis of Corrosion Protective Paint Systems for Al Alloys Based on Mg-Rich Primers

Lead Institution

North Dakota State University

Principal Investigator

Dante Battocchi

Project type

Exploratory Research

The goal of the proposed research is spectroscopic investigation of Mg corrosion products and Mg-rich primer interfaces by virtue of XPS analysis. To date, no XPS analyses have been performed on Mg…

Investigation of Secondary Organic Aerosol and Black Carbon Aging during the 2010 Carbonaceous Aerosol and Radiative Effects Study (CARES)

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Rahul Zaveri

Project type

Exploratory Research

Carbonaceous aerosols play a major role in the direct and indirect radiative forcing of climate. However, several mechanistic uncertainties and knowledge gaps still exist in our understanding of…

Dye Studies on CHO cells.

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

M. Mayer-Cumblidge

Project type

Exploratory Research

We have synthesized two dyes (FlAsH and ReAsH)which bind to a tetracysteine motif. We are seeking to optimize binding to a protein in living cells.

TEM and XPS analysis of ligand-functionalized semiconductor quantum dots used in biodetection studies

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Marvin Warner

Project type

Exploratory Research

The research included in this proposal involves the routine TEM and XPS analysis of functionalized semiconductor nanoparticles (primarily CdSe) that will serve as the signal transduction element in…

Separation and measurement of DNA from soil extracts

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Richard Ozanich

Project type

Exploratory Research

Fluidic methods for separating DNA from soil extracts will be developed. Background fluorescence of soil extracts will be determined to optimize selection of final hybridized DNA detection…

Investigation of cobalt active sites in cobalt-based catalyst for higher alcohol synthesis from synga

Lead Institution

Seoul National University

Principal Investigator

Do Heui Kim

Project type

Exploratory Research

The higher alcohol synthesis, which produces higher alcohol (C6-C18 alpha alcohol) for transportation fuel or fuel additives by reacting synthesis gas (CO and H2), is at the heart of the gas-to…

Micromodel Pore-Scale Displacement Studies of Brine and Supercritical CO2

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Mart Oostrom

Project type

Exploratory Research

Supercritical carbon dioxide (scCO2) sequestration in deep saline aquifers or reservoirs is, to a large extent, affected by porous medium properties, fluid properties, and interfacial interactions…

Proteomics of Arabidopsis thaliana and Poplar tree plastids: Understanding carbon allocation through the phenylpropanoid pathway

Lead Institution

Washington State University

Principal Investigator

Norman Lewis

Project type

Large-Scale EMSL Research

In this proposal, we wish to investigate, identify, and establish the factors affecting phenylalanine (Phe) biosynthesis in plastids of vascular plants, together with that of its transport to the…

MBE Growth and Properties of Model TiO2 Anatase Surfaces for Fundamental Studies of Heterogeneous Photocatalysis

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Scott Chambers

Project type

Large-Scale EMSL Research

The overall objective of this work is to provide the field of heterogeneous photocatalysis with unique insights into the molecular-level properties of photocatalytic transformations on TiO2 anatase…