Projects

Modeling complex bacterial cell systems through development of segregated models with spatial localization

Lead Institution

Oregon State University

Principal Investigator

Brian Wood

Project type

Exploratory Research

Systems of cells can exhibit behavior that is more complex than is expressed by individuals within the population. An example here might the be the formation of biofilms on surfaces. Because of the…

Single Molecule Dymanics of Protein DNA Interactions

Lead Institution

Washington State University

Principal Investigator

Alexander Li

Project type

Exploratory Research

Deoxyribonucleic acid (DNA) and protein interactions are ubiquitous biological systems and their interactions play critical roles in controlling functional cellular systems and abnormal cell…

Using the environmental scanning electron microscope for studying the atmospheric transformations of organic and inorganic particles

Lead Institution

Weizmann Institute

Principal Investigator

Yinon Rudich

Project type

Exploratory Research

Atmospheric aerosols are widely recognized as key elements in many environmental issues ranging from global climate change and visibility, through modification of the hydrological cycle to adverse…

Fluorescence Imaging of Cellular Protein Dynamics

Lead Institution

Brigham Young University

Principal Investigator

Gretchen Carr

Project type

Exploratory Research

Advance fluorescence advanced technology will be used to study the interactions of proteins at the cell membrane and within the cytoplasm to better understand the molecular cascades underlying…

Electrochemical and AFM/STM Study of TiO2 (Anatase) Film on SrTiO3 Substrate

Lead Institution

J. Heyrovsky Institute of Physical Chemistry

Principal Investigator

Ladislav Kavan

Project type

Exploratory Research

We propose to carry out electrochemical and AFM/STM microscopic investigation of highly organized TiO2 (anatase) layer deposited on conductive SrTiO3 substrate. With reference to our informal…

In-Situ/Liquid Time-of-Flight Secondary Ion Mass Spectrometry (TOF-SIMS) for Environmental Interfaces

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

James Cowin

Project type

Exploratory Research

Chemistry of liquid interfaces is extremely important in environmental and industrial processes but is poorly understood. Liquid layers coat nearly all real-world systems from the oceans to…

Oxydation of Fe/Cu and Fe/Ag multilayer
films prepared by DC magnetron sputtering

Lead Institution

McGill University

Principal Investigator

Alexandre Kouprine

Project type

Exploratory Research

Thin Fe films exhibit a variety of properties important for practical applications such as strong perpendicular magnetic anisotropy, spin reorientation transition, and magnetic moment …

Molecular dysfunction in alcoholic liver disease.

Lead Institution

Wayne State University

Principal Investigator

Amit Banerjee

Project type

Exploratory Research

Mice transgenic for the human Cytochrome P450 2E1 (primary metabolizer of alcohols in the liver) were fed alcohol intra-gastrically for a month. Upon examination of the liver microscopically,…

Engineering Device Surfaces That Instruct Cell Behavior

Lead Institution

University of Washington

Principal Investigator

Allison Golden

Project type

Exploratory Research

The development of material interfaces that control cell behavior is a central challenge for the fields of diagnostics, drug screening, biomaterials, biosensors, and tissue engineering. The…

Characterization of Natural Gas Methane Hydrate Rich Sediment

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Herbert Schaef

Project type

Exploratory Research

Synthetic and natural gas hydrate samples (NGHP-01, Mt Elbert) will be characterized by FIB-SEM equipped with a cryo stage and residual gas analyzer. Gas hydrate dissociation profiles collected on…

Signal Transmissions in 3-Dimensional Cell Structures

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Lee Opresko

Project type

Exploratory Research

MCF 10A cells will be examined for signal transduction in response to external stimulus.

Characterization of Regenerable CO2 Sorbents

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Feng Zheng

Project type

Exploratory Research

Several modified mesoporous silica and activated carbon sorbents were developed at PNNL for CO2 removal. Initial tests show that these sorbents have high adsorption capacity for CO2. The work…

Abundance of protein components in photosystem II protein complex purified from mutant cyanobacterial cells lacking individual subunit protein

Lead Institution

Washington University in St. Louis

Principal Investigator

Himadri Pakrasi

Project type

Exploratory Research

Photosystem II (PSII) is the pigment-protein complex responsible for the process of converting water to molecular oxygen and subsequent carbon fixation during oxygenic photosynthesis. PSII consists…

Using Mass Spectrometry to Assist in Identifying Genes for Enzymes of Known Activity, Unknown OpenReadingFrame and Small Abundance

Lead Institution

Washington University in St. Louis

Principal Investigator

Daniel Kohl

Project type

Exploratory Research

We have reported the identification of the Open Reading Frame (ORF) that expresses a NADPH-dependent methylglyoxal reducing enzyme based on the partial purification of this activity through 3 simple…

Chemical Processing of Terpene Emissions from Forests

Lead Institution

Argonne National Laboratory

Principal Investigator

Paul Doskey

Project type

Exploratory Research

Evaluations of NMOC emission inventories developed for rural and urban areas (which contain large uncertainties) necessitate direct measurement of landscape-scale fluxes. The main objectives of this…

The characterization of the SiC/SiO2/C composite

Lead Institution

Washington State University Tri-Cities

Principal Investigator

Hai-Feng Zhang

Project type

Exploratory Research

We have developed an approach to synthesize the nano-crysatlline composite materials of SiC/SiO2/C, TGA and FTIR are very efficient tools for determining the ratio of the componens in the composite…

Computational Investigation of the Fixed Charge Derivative Tris[(2,4,6-trimethoxyphenyl) phosphonium]

Lead Institution

University of Arizona

Principal Investigator

Kristin Herrmann

Project type

Exploratory Research

Proteomic studies often rely upon liquid chromatography (LC)/tandem mass spectrometry (MS) measurements in conjunction with sequencing algorithms for the identification of proteins. When a peptide…

Fuel-Neutral Studies of Particulate Matter Transportation Emissions

Lead Institution

University of Wisconsin, Madison

Principal Investigator

David Foster

Project type

Exploratory Research

Customers and governments are demanding greater fuel efficiency in light duty engine applications. Since the majority of light duty engines in North America are fueled by gasoline, gasoline engine…

The Role of Interfacial Processes on Mineral Transformations in Wet Supercritical CO2

Lead Institution

Washington State University

Principal Investigator

Andrew Felmy

Project type

Exploratory Research

We propose a comprehensive experimental and theoretical investigation of the role of interfacial water and CO2 on the energies, mechanisms, and rates of reactivity of a series of orthosilicate and…

Enhanced Amendment Delivery to Low Permeability Zones in Unconfined Aquifers Using Shear-Thinning Fluid

Lead Institution

GSI Environmental Inc.

Principal Investigator

Charles Newell

Project type

Exploratory Research

Zhong et al. (2008) conducted a series of flow cell experiments in the EMSL Subsurface Flow and Transport Laboratory using the shear-thinning polymer xanthan gum to investigate the impact of polymer…