Chaevien S. Clendinen
Chemist
Dr. Chaevien Clendinen is an analytical chemist with the Biomolecular Pathways team. She is an expert in metabolomics data analysis and workflow development using a variety of analytical pipelines, including liquid chromatography mass spectrometry (LC-MS), gas chromatography MS (GC-MS), and nuclear magnetic resonance (NMR) spectroscopy. She is also an expert in structural elucidation using LC-MS and NMR.
Clendinen has 10 years of research experience across multiple disciplines, including analytical and physical chemistry, microbiology and virology, cancer biology, and biotechnology. At EMSL, Dr. Clendinen assists users in the collection and analysis of metabolomics data from a variety of sample matrices. She is currently working with PNNL researchers to improve LC, GC, and NMR metabolomics workflows and identification confidence.
Research Interests
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LC-MS method development and data analysis
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GC-MS data analysis and workflow development
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NMR workflow development and data analysis
Education
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PhD in Biochemistry and Molecular Biology, University of Florida, 2014
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Dissertation: Develop a method for 13C based metabolomics using 1D and 2D NMR
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BS in Biology, The University of North Carolina at Charlotte, 2009
Affiliations and Professional Service
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Senior Nutrition Scientist, Health Science and Nutrition Affairs, Division of Research Development and Engineering, Ocean Spray Cranberries Inc, 2017-2019
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Postdoctoral Fellow, Department of Chemistry and Biochemistry, Georgia Institute of Technology (Advisor: Dr. Facundo Fernandez), 2015-2017
Publications
2022
Ulrich, Danielle EM, Chaevien S. Clendinen, Franklin Alongi, Rebecca C. Mueller, Rosalie K. Chu, Jason Toyoda, La Verne Gallegos-Graves et al. "Root exudate composition reflects drought severity gradient in blue grama (Bouteloua gracilis)." Scientific Reports 12, no. 1 (2022): 1-16.
Jardine, Kolby J., Joseph Lei, Suman Som, Daisy Souza, Chaevien S. Clendinen, Hardeep Mehta, Pubudu Handakumbura, Markus Bill, and Robert P. Young. "Light-Dependence of Formate (C1) and Acetate (C2) Transport and Oxidation in Poplar Trees." Plants 11, no. 16 (2022): 2080.
2021
Dewhirst, Rebecca A., Pubudu Handakumbura, Chaevien S. Clendinen, Eva Arm, Kylee Tate, Wenzhi Wang, Nancy M. Washton et al. "High Temperature Acclimation of Leaf Gas Exchange, Photochemistry, and Metabolomic Profiles in Populus trichocarpa." ACS Earth and Space Chemistry 5, no. 8 (2021): 1813-1828.
Chroumpi, Tania, Mao Peng, Lye Meng Markillie, Hugh D. Mitchell, Carrie D. Nicora, Chelsea M. Hutchinson, Vanessa Paurus et al. "Re-routing of sugar catabolism provides a better insight into fungal flexibility in using plant biomass-derived monomers as substrates." Frontiers in bioengineering and biotechnology 9 (2021): 167.
2019
Chaevien S. Clendinen, David A. Gual, María Eugenia Monge, Rebecca S. Arnold, Arthur S. Edison, John A. Petros, Facundo M. Fernández (2019). "Preoperative Metabolic Signatures of Prostate Cancer Recurrence Following Radical Prostatectomy." Journal of Proteome Research 18(3): 1316-1327.
2017
Chaevien S. Clendinen, María Eugenia Monge, and Facundo M. Fernández. Ambient Mass Spectrometry in Metabolomics. (2017) Analyst. 142(17), pp 3101-3117.
2016
Chaevien S. Clendinen, Gregory S. Stupp, Bing Wang, Timothy J. Garrett, and Arthur S. Edison. 13C Metabolomics: NMR and IROA for Unknown Compound Identification. (2016) Current Metabolomics. 4(2) pp. 116-120(5)
2015
Chaevien S. Clendinen, Gregory S. Stupp, Brittany Lee-McMullen, Ramadan Ajredini, Chris Beecher, and Arthur S. Edison. An Overview of Methods for Improved Compound Identification in Metabolomics and Natural Products Using 13C. (2015) Review, Front. Plant Sci. 6 (611). DOI: 10.3389/fpls.2015.00611
Bing Wang, Elizabeth Park, Jarrod King, Allison Mattes, Susan L. Nimmo, Chaevien Clendinen, Arthur S. Edison, Robert H. Cichewicz. Transferring Fungi to a Deuterium-Enriched Medium Results in Assorted, Conditional Changes in Secondary Metabolite Production. (2015). Journal of Natural Products. 78 (6), pp 1415–1421
Arthur S. Edison, Chaevien S. Clendinen, Ramadan Ajredini, Chris Beecher, Francesca Ponce, Gregory S. Stupp. Metabolomics and Natural Products Strategies to Study Chemical Ecology in Nematodes. (2015) Review, Integrative and Comparative Biology. DOI: 10.1093/icb/icv077
Chaevien S. Clendinen, Christian Pasquel, Ramadan Ajredini, and Arthur Edison. 13C-labeled Metabolomics approach for analysis of 13C-labeled C. elegans using INADEQUATE. (2015) Analytical Chemistry. 87 (11), pp 5698–5706
Robert F. Menger, Chaevien S. Clendinen, Louis A. Searcy, Arthur S. Edison, and Richard A. Yost. (2015). MALDI Mass Spectrometric Imaging of Caenorhabditis elegans. Current Metabolomics. 3(2), pp 130-137
2014
Chaevien S. Clendinen, Brittany A. Lee-McMullen, Caroline Williams, Gregory S. Stupp, Krista Vandenborne, Daniel A. Hahn, Glenn A. Walter, and Arthur S. Edison. (2014). 13C NMR Metabolomics: Applications at Natural Abundance. Analytical Chemistry. 86(18), pp 9242-9250.
2013
Gregory S. Stupp, Chaevien S. Clendinen, Ramadan Ajredini, Mark A. Szewc, Timothy Garrett, Robert F. Menger, Richard A. Yost, Chris Beecher, and Arthur S. Edison. (2013). Isotopic ratio outlier analysis global metabolomics of Caenorhabditis elegans. Analytical Chemistry, 85(24), pp 11858–11865.
2007
Chaevia S. Clendinen, Chaevien Clendinen, Wade N. Sisk, Hiromasa Nishikiori, and Nobuaki Tanaka, Tsuneo Fuji. (2007). Energy transfer and photodegradation of Perylene Red with DTTC and HITC acceptor dyes in PMMA. Dyes and Pigments, 77(1), pp 92-97.