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Erin Bredeweg
Biologist

Erin Bredeweg is a fungal biologist and geneticist who works with the Environmental Molecular Sciences Laboratory's Cell Signaling and Communication Integrated Research Platform. Her interests include utilizing the enzymatic and biosynthetic power of fungal metabolism, the importance of localization in cellular function, and ways to use cell biology insights for design of useful products and capabilities. Her current areas of work will deepen our understanding and application of fungal cell biology and address national fuel and product provision from the U.S. Department of Energy missions.

Research Interests

  • Fungal cell biology and regulation
  • Transcriptional and regulatory networks
  • Molecular genetics
  • Subcellular localization and function
  • Live cell imaging
  • Synthetic and exogenous pathway construction
  • Bio-feedstock usage and consortia
  • Symbiotic and mutualistic interactions with plants and other microbes

Education

  • PhD in Molecular and Cellular Biology, Oregon State University, 2014
  • BS in Zoology, University of Washington, 2004

Affiliations and Professional Service

  • Society for Industrial Microbiology and Biotechnology, 2017-present
  • Genetics Society of America, 2009-Present
  • America Association for the Advancement of Science, 2008-2015

Publications

2020

Burnet M.C., D. Zamith-Miranda, H.M. Heyman, K.K. Weitz, E.L. Bredeweg, J.D. Nosanchuk, and E.S. Nakayasu. 2020. "Remodeling of the Histoplasma capsulatum membrane induced by monoclonal antibodies." Vaccines 8, no. 2:269. PNNL-SA-152362. doi:10.3390/vaccines8020269

Bredeweg E.L., and S.E. Baker. 2020. "Horizontal gene transfer in Fungi." In Grand Challenges in Fungal Biotechnology, edited by Helena Nevalainen. 317-332. PNNL-SA-143450. doi:10.1007/978-3-030-29541-7

Subedi N.R., P.S. Jung, E.L. Bredeweg, S.H. Nemati, S.E. Baker, D.N. Christodoulides, and A.E. Vasdekis. 2020. "Integrative Quantitative-Phase and Airy Light-Sheet Imaging." SREP.

2019

Zamith-Miranda D., H.M. Heyman, L.G. Cleare, S.P. Couvillion, G. Clair, E.L. Bredeweg, and A. Gacser, et al. 2019. "Multi-omics signature of Candida Auris, an emerging and multidrug-resistant pathogen." mSystems 4, no. 4:e00257-19. PNNL-SA-140174. doi:10.1128/mSystems.00257-19

2018

Pomraning, K. R., E. L. Bredeweg, E. J. Kerkhoven, K. Barry, S. Haridas, H. Hundley, K. LaButti, A. Lipzen, M. Yan, J. K. Magnuson, B. A. Simmons, I. V. Grigoriev, J. Nielsen, and S. E. Baker. 2018. “Regulation of Yeast-to-Hyphae Transition in Yarrowia lipolytica.” mSphere 3 (6). doi.org/10.1128/mSphereDirect.00541-18.  

Pomraning, K. R., E. L. Bredeweg, E. J. Kerkhoven, K. Barry, S. Haridas, H. Hundley, K. LaButti, A. Lipzen, M. Yan, J. K. Magnuson, B. A. Simmons, I. V. Grigoriev, J. Nielsen, and S. E. Baker. 2018. “Regulation of Yeast-to-Hyphae Transition in Yarrowia lipolytica.” mSphere 3 (6). doi.org/10.1128/MSPHERE.00541-18.

Bredeweg E.L., and S.E. Baker. 2018. "Analysis of Intracellular Metabolic Pathway Localization in Y. lipolytica." In Methods in Molecular Biology. PNNL-SA-138024.

2017

Bredeweg E.L., K.R. Pomraning, Z. Dai, J.B. Nielsen, E.J. Kerkhoven, and S.E. Baker. 2017. "A Molecular Genetic Toolbox for Yarrowia lipolytica." Biotechnology for Biofuels 10. PNNL-SA-118953. doi:10.1186/s13068-016-0687-7

Dekhang, R., C. Wu, K. M. Smith, T. M. Lamb, M. Peterson, E. L. Bredeweg, O. Ibarra, J. M. Emerson, N. Karunarathna, A. Lyubetskaya, E. Azizi, J. M. Hurley, J. C. Dunlap, J. E. Galagan, M. Freitag, M. S. Sachs, and D. Bell-Pedersen. 2017. “The Neurospora Transcription Factor ADV-1 Transduces Light Signals and Temporal Information to Control Rhythmic Expression of Genes Involved in Cell Fusion.” G3: Genes, Genomes, Genetics 7 (1): 129-142. doi.org/10.1534/g3.116.034298.

Geng T., C.R. Smallwood, E.L. Bredeweg, K.R. Pomraning, A.E. Plymale, S.E. Baker, and J.E. Evans, et al. 2017. "Multimodal Microfluidic Platform for Controlled Culture and Analysis of Unicellular Organisms." Biomicrofluidics 11, no. 5:054104. PNNL-SA-129125. doi:10.1063/1.4986533

Geng T., C.R. Smallwood, Y. Zhu, E.L. Bredeweg, S.E. Baker, J.E. Evans, and R.T. Kelly. 2017. "Multimodal Microchannel and Nanowell-Based Microfluidic Platforms for Bioimaging." In Proceedings of the 10th IEEE International Conference on Nano/Molecular Medicine and Engineering (NANOMED 2016), October 30- November 2, 2016, Macau, China, 155-158. Piscataway, New Jersey:IEEE. PNNL-SA-124699. doi:10.1109/NANOMED.2016.7883480

Pomraning K.R., E.L. Bredeweg, and S.E. Baker. 2017. "Regulation of nitrogen metabolism by GATA zinc-finger transcription factors in Yarrowia lipolytica." mSphere 2, no. 1:Article No. 00038-17. PNNL-SA-122638. doi:10.1128/mSphere.00038-17

Dekhang, R., C. Wu, K. M. Smith, T. M. Lamb, M. Peterson, E. L. Bredeweg, O. Ibarra, J. M. Emerson, N. Karunarathna, A. Lyubetskaya, E. Azizi, J. M. Hurley, J. C. Dunlap, J. E. Galagan, M. Freitag, M. S. Sachs, and D. Bell-Pedersen. 2017. “The Neurospora Transcription Factor ADV-1 Transduces Light Signals and Temporal Information to Control Rhythmic Expression of Genes Involved in Cell Fusion.” G3: Genes, Genomes, Genetics 7 (1): 129-142. doi.org/10.1534/g3.116.034298.

Qi, Z., K. M. Smith, E. L. Bredeweg, N. Bosnjak, M. Freitag, and F. E. Nargang. 2017. “Alternative Oxidase Transcription Factors AOD2 and AOD5 of Neurospora crassa Control the Expression of Genes Involved in Energy Production and Metabolism.” G3: Genes, Genomes, Genetics 7 (2): 449-466. doi.org/10.1534/g3.116.035402.

2016

Pomraning K.R., Y. Kim, C.D. Nicora, R.K. Chu, E.L. Bredeweg, S.O. Purvine, and D. Hu, et al. 2016. "Multi-omics analysis reveals regulators of the response to nitrogen limitation in Yarrowia lipolytica." BMC Genomics 17, no. 138:1-18. PNNL-SA-112784. doi:10.1186/s12864-016-2471-2

Geng, T., C. R. Smallwood, Y. Zhu, E. L. Bredeweg, S. E. Baker, J. E. Evans, and R. T. Kelly. 2016. “Multimodal Microchannel and Nanowell-Based Microfluidic Platforms for Bioimaging.” Proceedings of the 10th IEEE International Conference on Nano/Molecular Medicine and Engineering (NANOMED 2016), Macau, China. doi.org/10.1109/NANOMED.2016.7883480.

Mäkelä, M. R., E. L. Bredeweg, J. K. Magnuson, S. E. Baker, R. P. de Vries, and K. Hildén. 2016. “Fungal Ligninolytic Enzymes and Their Applications.” Microbiology Spectrum 4 (6). doi.org/10.1128/microbiolspec.FUNK-0017-2016.

2015

Geng T., E.L. Bredeweg, C.J. Szymanski, B. Liu, S.E. Baker, G. Orr, and J.E. Evans, et al. 2015. "Compartmentalized microchannel array for high-throughput analysis of single cell polarized growth and dynamics." Scientific Reports 5. PNNL-SA-109268. doi:10.1038/srep16111

Pomraning K.R., S. Wei, S.A. Karagiosis, Y. Kim, A. Dohnalkova, B.W. Arey, and E.L. Bredeweg, et al. 2015. "Comprehensive metabolomic, lipidomic and microscopic profiling of Yarrowia lipolytica during lipid accumulation identifies targets for increased lipogenesis." PLoS One 10, no. 4:e0123188. PNNL-SA-105704. doi:10.1371/journal.pone.0123188

2014

Riquelme, M., E. L. Bredeweg, O. Callejas-Negrete, R. W. Roberson, S. Ludwig, A. Beltrán-Aguilar, S. Seiler, P. Novick, and M. Freitag. 2014. “The Neurospora crassa Exocyst Complex Tethers Spitzenkörper Vesicles to the Apical Plasma Membrane During Polarized Growth.” Molecular Biology of the Cell 25 (8): 1312-1326. doi.org/10.1091/mbc.E13-06-0299.   

Wu, C., F. Yang, K. M. Smith, M. Peterson, R. Dekhang, Y. Zhang, J. Zucker, E. L. Bredeweg, C. Mallappa, X. Zhou, A. Lyubetskaya, J. P. Townsend, J. E. Galagan, M. Freitag, J. C. Dunlap, D. Bell-Pedersen, and M. S. Sachs. 2014. “Genome-Wide Characterization of Light-Regulated Genes in Neurospora crassa.” G3: Genes, Genomes, Genetics 4 (9): 1731-1745. doi.org/10.1534/g3.114.012617.  

2012

Pomraning, K. R., K. M. Smith, E. L. Bredeweg, L. R. Connolly, P. A. Phatale, and M. Freitag. 2012. Library Preparation and Data Analysis Packages for Rapid Genome Sequencing. Fungal Secondary Metabolism (Methods in Molecular Biology) 944: 1-22. doi:10.1007/978-1-62703-122-6_1.    

2010

Smith, K. M., G. Sancar, R. Dekhang, C. M. Sullivan, S. Li, A. G. Tag, C. Sancar, E. L. Bredeweg, H. D. Priest, R. F. McCormick, T. L. Thomas, J. C. Carrington, J. E. Stajich, D. Bell-Pedersen, M. Brunner, and M. Freitag. 2010. “Transcription Factors in Light and Circadian Clock Signaling Networks Revealed by Genomewide Mapping of Direct Targets for Neurospora White Collar Complex.” Eukaryotic Cell 9 (10): 1549-1556. doi.org/10.1128/EC.00154-10.  

2009

Chappell, P. E., C. P. Goodall, K. J. Tonsfeldt, R. S. White, E. Bredeweg, and K. L. Latham. 2009. “Modulation of Gonadotrophin-Releasing Hormone Secretion by an Endogenous Circadian Clock.” Journal of Neuroendocrinology 21 (4): 339-345. doi.org/10.1111/j.1365-2826.2009.01845.x.