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Kathryn Ely

Institution
The Burnham Institute

Projects

Structure of a Helical Signaling Domain from p130Cas

Lead Institution
The Burnham Institute
Principal Investigator
Kathryn Ely
Project type
Capability Research
The cellular responses to integrin signals are coordinated through specific protein-protein interactions. In this project, we focus on an adaptor protein called Cas that becomes phosphorylated upon…

Structure of a Helical Signaling Domain from p130Cas

Lead Institution
The Burnham Institute
Principal Investigator
Kathryn Ely
Project type
Capability Research
The cellular responses to integrin signals are coordinated through specific protein-protein interactions. In this project we focus on an adaptor protein called Cas that becomes phosphorylated upon…

Structure of a Helical Signaling Domain from Cas

Lead Institution
The Burnham Institute
Principal Investigator
Kathryn Ely
Project type
Capability Research
The cellular responses to integrin signals are coordinated through specific protein-protein interactions. In this project we focus on an adaptor protein called Cas that becomes phosphorylated upon…

Structural characterization of free and fibronectin-bound anastellin

Lead Institution
The Burnham Institute
Principal Investigator
Kathryn Ely
Project type
Capability Research
Anastellin is a carboxy-terminal fragment of the 1st FN3 domain from human fibronectin. It is capable of polymerizing fibronectin in vitro and it displays anti-tumor, anti-metastatic and anti…

Structure of the PR domain of RIZ1 tumor suppressor

Lead Institution
The Burnham Institute
Principal Investigator
Kathryn Ely
Project type
Capability Research
RIZ1 is a PR domain containing histone lysine methyltransferase and tumor suppressor activity that provides a link between dietary and genetic causes of cancer. We plan to determine the structure of…

Structure of the PR domain of RIZ1 tumor suppressor

Lead Institution
The Burnham Institute
Principal Investigator
Kathryn Ely
Project type
Capability Research
RIZ1 is a PR domain containing histone lysine methyltransferase with tumor suppressor activity that provides a link between dietary and genetic causes of cancer. We plan to determine the structure of…

Molecular Structure of BAG Proteins

Lead Institution
The Burnham Institute
Principal Investigator
Kathryn Ely
Project type
Capability Research
BAG-1 is a new protein that may contribute to treatment failure in some cancers. This protein was the first member identified from a family of homologous BAG proteins.

Solution Structure of BAG Domains: BAG-1 delta N

Lead Institution
The Burnham Institute
Principal Investigator
Kathryn Ely
Project type
Capability Research
BAG-1 is a novel multifunctional protein first identified as a molecule that binds to the anti-apoptotic protein Bcl-2. With the discovery that BAG-1 binds tightly to heat shock proteins Hsp70/Hsc70…

Protein Design, Protein Recognition and Molecular Chaperones

Lead Institution
The Burnham Institute
Principal Investigator
Kathryn Ely
Project type
Capability Research
Molecular chaperones such as heat shock proteins assist in protein folding by preventing misfolding and aggreagation, but also provide other vital cellular tasks such as import, translocation and…

Protein Design, Protein Recognition and Molecular Chaperones

Lead Institution
The Burnham Institute
Principal Investigator
Kathryn Ely
Project type
Capability Research
Molecular chaperones such as heat shock proteins assist in protein folding, import, translocation and degradation of proteins. A new protein called BAG1 binds to and modulates the chaperone activity…

Solution Structure of BAG Domains: BAG1dN

Lead Institution
The Burnham Institute
Principal Investigator
Kathryn Ely
Project type
Capability Research
BAG1 is a novel multifunctional protein first identified as a molecule that binds to the anti-apoptotic protein Bcl-2. With the discovery that BAG1 binds tightly to heat shock proteins Hsc70/Hsp70,…

BAG1 as a Link between Cell Growth and the Stress Response: An NMR Study

Lead Institution
The Burnham Institute
Principal Investigator
Kathryn Ely
Project type
Capability Research
BAG1 is a multifunctional protein that modulates responses to cell death and cell stress. The 'BAG domain', located in the C-terminal region of BAG1 is necessary for interactions with two…