Understanding Hepatitis B Infection: Structure of Hepatitis B Virus x Protein Bound to its Cellular
EMSL Project ID
2617
Abstract
Hepatitis B virus (HBV) infects more than 300 million people and is a leading cause of liver cancer and disease. The HBV protein X (HBX) is essential for infection and is proposed to act through protein-protein interactions. In the cytoplasm, it stimulates Ras, Src and c-Jun N-terminal kinase (JNK) signal transduction pathways; however, its molecular mechanism of action remains unknown. A cytosolic protein named HBX interacting protein (XIP) binds to HBX and is capable of inhibiting viral replication. Our goal is to determine the solution structure of the HBX/XIP complex
Project Details
Project type
Capability Research
Start Date
2002-10-01
End Date
2003-10-06
Status
Closed
Released Data Link
Team
Principal Investigator
Team Members