Spatial Properties of Clustered Free Radicals Produced in DNA and Biodosimeters by Ionizing Radiation
EMSL Project ID
2448a
Abstract
This application seeks to continue our EMSL project centered on the spatial properties of trapped free radicals in irradiated DNA and in tooth enamel, which is increasingly being used as a retrospective biodosimeter for the measurement of radiation exposure. T his information on irradiated tooth enamel may allow the development of methodology to determine the average energy and type of radiation to which the enamel was exposed, thus increasing the usefulness of this material as a biodosimeter. With reference to DNA, this information is needed in order to develop a better understanding of the mechanisms involved in the production of DNA damage which may not be repaired, or may be misrepaired, in cells and thus may lead to deleterious health effects. Models incorporating the data from this project will be more accurate in their prediction of risks for such adverse health effects as cancer from exposure to low doses of radiation. The results of these studies should be of interest to DOE programs responsible for radiation safety and worker health.
Project Details
Project type
Capability Research
Start Date
2003-04-12
End Date
2004-04-09
Status
Closed
Released Data Link
Team
Principal Investigator